Search Results - "H. Xu"

RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 by Jiang, Yi, Yin, Wanchao, Xu, H. Eric

“…Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although great…”
Get full text

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin by Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H.

“…The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old…”
Get full text

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase by Byun, Sangwon, Seok, Sunmi, Kim, Young-Chae, Zhang, Yang, Yau, Peter, Iwamori, Naoki, Xu, H. Eric, Ma, Jian, Kemper, Byron, Kemper, Jongsook Kim

“…Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy…”
Get full text

Structure and Physiological Regulation of AMPK by Yan, Yan, Zhou, X Edward, Xu, H Eric, Melcher, Karsten

“…Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric αβγ complex that functions as a central regulator of energy homeostasis…”
Get full text

A complex structure of arrestin-2 bound to a G protein-coupled receptor by Yin, Wanchao, Li, Zhihai, Jin, Mingliang, Yin, Yu-Ling, de Waal, Parker W., Pal, Kuntal, Yin, Yanting, Gao, Xiang, He, Yuanzheng, Gao, Jing, Wang, Xiaoxi, Zhang, Yan, Zhou, Hu, Melcher, Karsten, Jiang, Yi, Cong, Yao, Edward Zhou, X., Yu, Xuekui, Eric Xu, H.

“…Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs), which include arrestins 1 to 4. While arrestins 1 and 4 are visual…”
Get full text

Amyloid beta： structure, biology and structure-based therapeutic development by Chen, Guo-fang, Xu, Ting-hai, Yan, Yan, Zhou, Yu-ren, Jiang, Yi, Melcher, Karsten, Xu, H Eric

“…Amyloid beta peptide （Aβ） is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein （APP）, by β- and y-secretases…”
Get full text

Structure and dynamics of the active human parathyroid hormone receptor-1 by Zhao, Li-Hua, Ma, Shanshan, Sutkeviciute, Ieva, Shen, Dan-Dan, Zhou, X Edward, de Waal, Parker W, Li, Chen-Yao, Kang, Yanyong, Clark, Lisa J, Jean-Alphonse, Frederic G, White, Alex D, Yang, Dehua, Dai, Antao, Cai, Xiaoqing, Chen, Jian, Li, Cong, Jiang, Yi, Watanabe, Tomoyuki, Gardella, Thomas J, Melcher, Karsten, Wang, Ming-Wei, Vilardaga, Jean-Pierre, Xu, H Eric, Zhang, Yan

“…The parathyroid hormone receptor-1 (PTH1R) is a class B G protein-coupled receptor central to calcium homeostasis and a therapeutic target for osteoporosis and…”
Get full text

Topological energy transfer in an optomechanical system with exceptional points by Xu, H., Mason, D., Jiang, Luyao, Harris, J. G. E.

“…The transfer of energy between two vibrational modes of an optomechanical device is achieved using topological operations; the key to this transfer is the…”
Get full text

Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells by Lin, C, Wang, Y, Zhang, S, Yu, L, Guo, C, Xu, H

“…The long non-coding RNA, HOTTIP, has an important role in tumorigenesis. It is known that HOTTIP regulates HOX gene family; however, its regulatory mechanism…”
Get full text

Structural biology of G protein‐coupled receptor signaling complexes by Edward Zhou, X., Melcher, Karsten, Eric Xu, H.

“…G protein‐coupled receptors (GPCRs) constitute the largest family of cell surface receptors that mediate numerous cell signaling pathways, and are targets of…”
Get full text

Autoimmune glial fibrillary acidic protein astrocytopathy in Chinese patients: a retrospective study by Long, Y., Liang, J., Xu, H., Huang, Q., Yang, J., Gao, C., Qiu, W., Lin, S., Chen, X.

“…Background and purpose The aim was to describe the clinical, radiological and pathological features of an autoimmune glial fibrillary acidic protein (GFAP)…”
Get full text

Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019—a multi-centre observational study by Cen, Y., Chen, X., Shen, Y., Zhang, X.-H., Lei, Y., Xu, C., Jiang, W.-R., Xu, H.-T., Chen, Y., Zhu, J., Zhang, L.-L., Liu, Y.-H.

“…Since December 2019, the novel coronavirus disease 2019 (COVID-19) that emerged in Wuhan city has spread rapidly around the world. The risk for poor outcome…”
Get full text

Structural basis of leukotriene B4 receptor 1 activation by Wang, Na, He, Xinheng, Zhao, Jing, Jiang, Hualiang, Cheng, Xi, Xia, Yu, Eric Xu, H., He, Yuanzheng

“…Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the…”
Get full text

Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis by Xiao, P.-L., Cui, A.-Y., Hsu, C.-J., Peng, R., Jiang, N., Xu, X.-H., Ma, Y.-G., Liu, D., Lu, H.-D.

“…   This systematic review and meta-analysis estimated the global, regional prevalence, and risk factors of osteoporosis. Prevalence varied greatly according to…”
Get full text

Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma by Wang, W.-Q., Liu, L., Xu, H.-X., Wu, C.-T., Xiang, J.-F., Xu, J., Liu, C., Long, J., Ni, Q.-X, Yu, X.-J.

“…Background The aim of this study was to assess the immune profile within the microenvironment of pancreatic ductal adenocarcinoma (PDAC), and to investigate…”
Get full text

Nonreciprocal control and cooling of phonon modes in an optomechanical system by Xu, H., Jiang, Luyao, Clerk, A. A., Harris, J. G. E.

“…Mechanical resonators are important components of devices that range from gravitational wave detectors to cellular telephones. They serve as high-performance…”
Get full text

Mixed convection flow of a nanofluid over a stretching surface with uniform free stream in the presence of both nanoparticles and gyrotactic microorganisms by Xu, H., Pop, I.

“…In this paper, a detailed analysis is given for the mixed convection flow of a nanofluid over a stretching surface with uniform free stream in the presence of…”
Get full text

Efficient light management in vertical nanowire arrays for photovoltaics by Anttu, Nicklas, Xu, H Q

“…Vertical arrays of direct band gap III-V semiconductor nanowires (NWs) hold the prospect of cheap and efficient next-generation photovoltaics, and guidelines…”
Get full text

Efficient light management in vertical nanowire arrays for photovoltaics by Anttu, Nicklas, Xu, H Q

“…Vertical arrays of direct band gap III-V semiconductor nanowires (NWs) hold the prospect of cheap and efficient next-generation photovoltaics, and guidelines…”
Get full text

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir by Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric

“…The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis…”
Get full text