Search Results - "H. Seifert"
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Neisseria gonorrhoeae host adaptation and pathogenesis
Published in Nature reviews. Microbiology (01-04-2018)“…Key Points The urogenital tract is a complex environment composed of many different types of epithelial tissues and innate immune cells that sample the…”
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Location, Location, Location—Commensalism, Damage and Evolution of the Pathogenic Neisseria
Published in Journal of molecular biology (26-07-2019)“…The 10 human-restricted Neisseria species all colonize mucosal surfaces, but show a spectrum of pathogenicity. The commensal Neisseria do not normally cause…”
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3
Above and Beyond Watson and Crick: Guanine Quadruplex Structures and Microbes
Published in Annual review of microbiology (08-09-2018)“…Advances in understanding mechanisms of nucleic acids have revolutionized molecular biology and medicine, but understanding of nontraditional nucleic acid…”
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Transcription of a cis-acting, noncoding, small RNA is required for pilin antigenic variation in Neisseria gonorrhoeae
Published in PLoS pathogens (01-01-2013)“…The strict human pathogen Neisseria gonorrhoeae can utilize homologous recombination to generate antigenic variability in targets of immune surveillance. To…”
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Structured reporting of prostate magnetic resonance imaging has the potential to improve interdisciplinary communication
Published in PloS one (19-02-2019)“…Effective interdisciplinary communication of imaging findings is vital for patient care, as referring physicians depend on the contained information for the…”
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The Genetics of Neisseria Species
Published in Annual review of genetics (01-01-2014)“…Neisseria gonorrhoeae and Neisseria meningitidis are closely related organisms that cause the sexually transmitted infection gonorrhea and serious bacterial…”
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Influence of mean stress and light water reactor environment on fatigue life and dislocation microstructures of 316L austenitic steel
Published in Journal of nuclear materials (01-10-2018)“…Influence of mean stress on fatigue life of the austenitic stainless steel 316 L in air and light water environments (boiling water reactor/hydrogen water…”
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Microbial antigenic variation mediated by homologous DNA recombination
Published in FEMS microbiology reviews (01-09-2012)“…Abstract Pathogenic microorganisms employ numerous molecular strategies in order to delay or circumvent recognition by the immune system of their host. One of…”
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Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
Published in Molecular cell (23-05-2013)“…CRISPR interference confers adaptive, sequence-based immunity against viruses and plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and…”
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An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in Neisseria gonorrhoeae
Published in Science (American Association for the Advancement of Science) (07-08-2009)“…Pathogens can use DNA recombination to promote antigenic variation (Av) of surface structures to avoid immune detection. We identified a cis-acting DNA…”
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DNase H Activity of Neisseria meningitidis Cas9
Published in Molecular cell (15-10-2015)“…Type II CRISPR systems defend against invasive DNA by using Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks. Dual RNAs (CRISPR RNA…”
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Gonorrhoea
Published in Nature reviews. Disease primers (21-11-2019)“…The bacterium Neisseria gonorrhoeae causes the sexually transmitted infection (STI) gonorrhoea, which has an estimated global annual incidence of 86.9 million…”
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The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron
Published in PLoS pathogens (01-06-2022)“…The Neisseria gonorrhoeae Type IV pilus is a multifunctional, dynamic fiber involved in host cell attachment, DNA transformation, and twitching motility. We…”
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Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe
Published in Clinical microbiology and infection (01-05-2012)“…Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming…”
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Haemophilus spills its guts to make a biofilm
Published in Proceedings of the National Academy of Sciences - PNAS (08-08-2017)Get full text
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A bacterial siren song: intimate interactions between Neisseria and neutrophils
Published in Nature reviews. Microbiology (01-03-2012)“…Key Points The pathogenic Neisseria species, Neisseria gonorrhoeae and Neisseria meningitidis , are obligate human bacteria that share many properties and…”
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A Double-Strand Break Does Not Promote Neisseria gonorrhoeae Pilin Antigenic Variation
Published in Journal of bacteriology (01-07-2019)“…The major subunit of the type IV pilus (T4p) of undergoes antigenic variation (AV) dependent on a guanine quadruplex (G4) DNA structure located upstream of the…”
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RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes
Published in Structure (London) (05-12-2012)“…Neisseria gonorrhoeae is an obligate human pathogen that can escape immune surveillance through antigenic variation of surface structures such as pili. A…”
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The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation
Published in PLoS genetics (23-05-2016)“…The obligate human pathogen Neisseria gonorrhoeae is the sole aetiologic agent of the sexually transmitted infection, gonorrhea. Required for gonococcal…”
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Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study)
Published in Gut (01-09-2009)“…As with endoscopic transmural drainage of peripancreatic fluid collections, the same transluminal access can be expanded to introduce an endoscope through the…”
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