Search Results - "H. Chishti, Athar"

Proteomic and functional analyses of the periodic membrane skeleton in neurons by Zhou, Ruobo, Han, Boran, Nowak, Roberta, Lu, Yunzhe, Heller, Evan, Xia, Chenglong, Chishti, Athar H., Fowler, Velia M., Zhuang, Xiaowei

“…Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. The molecular composition and functions of the MPS…”
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Transport of PIP₃ by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity by Horiguchi, Kaori, Hanada, Toshihiko, Fukui, Yasuhisa, Chishti, Athar H

“…Phosphatidylinositol-(3,4,5)-trisphosphate (PIP₃), a product of phosphatidylinositol 3-kinase, is an important second messenger implicated in signal…”
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Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology by Wieschhaus, Adam, Khan, Anwar, Zaidi, Asma, Rogalin, Henry, Hanada, Toshihiko, Liu, Fei, De Franceschi, Lucia, Brugnara, Carlo, Rivera, Alicia, Chishti, Athar H

“…Pharmacological inhibitors of cysteine proteases have provided useful insights into the regulation of calpain activity in erythrocytes. However, the precise…”
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Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival by Takano, Jiro, Mihira, Naomi, Fujioka, Ryo, Hosoki, Emi, Chishti, Athar H., Saido, Takaomi C.

“…OA  Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress by Yamada, Kaori H., Kozlowski, Dorothy A., Seidl, Stacey E., Lance, Steven, Wieschhaus, Adam J., Sundivakkam, Premanand, Tiruppathi, Chinnaswamy, Chishti, Imran, Herman, Ira M., Kuchay, Shafi M., Chishti, Athar H.

“…Calpains are calcium-regulated cysteine proteases that have been implicated in the regulation of cell death pathways. Here, we used our calpain-1 null mouse…”
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Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease by Nwankwo, Jennifer O, Lei, Jianxun, Xu, Jian, Rivera, Alicia, Gupta, Kalpna, Chishti, Athar H

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Calpain-1 contributes to IgE-mediated mast cell activation by Wu, Zhengli, Chen, Xiaochun, Liu, Fang, Chen, Wei, Wu, Ping, Wieschhaus, Adam J, Chishti, Athar H, Roche, Paul A, Chen, Wei-Min, Lin, Tong-Jun

“…Mast cells play a central role in allergy through secretion of both preformed and newly synthesized mediators. Mast cell mediator secretion is controlled by a…”
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Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice by Subramanian, Venkateswaran, Moorleghen, Jessica J, Balakrishnan, Anju, Howatt, Deborah A, Chishti, Athar H, Uchida, Haruhito A

“…Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine…”
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Pharmacological inhibition of calpain‐1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease by De Franceschi, Lucia, Franco, Robert S., Bertoldi, Mariarita, Brugnara, Carlo, Matté, Alessandro, Siciliano, Angela, Wieschhaus, Adam J., Chishti, Athar H., Joiner, Clinton H.

“…Sickle cell disease (SCD) is a globally distributed hereditary red blood cell (RBC) disorder. One of the hallmarks of SCD is the presence of circulating dense…”
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Dematin and Adducin Provide a Novel Link between the Spectrin Cytoskeleton and Human Erythrocyte Membrane by Directly Interacting with Glucose Transporter-1 by Khan, Anwar A., Hanada, Toshihiko, Mohseni, Morvarid, Jeong, Jong-Jin, Zeng, Lixiao, Gaetani, Massimiliano, Li, Donghai, Reed, Brent C., Speicher, David W., Chishti, Athar H.

“…Dematin and adducin are actin-binding proteins located at the spectrin-actin junctions, also called the junctional complex, in the erythrocyte membrane. Here…”
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Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets by Kuchay, Shafi M., Kim, Nayoung, Grunz, Elizabeth A., Fay, William P., Chishti, Athar H.

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Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial - the safe iron study by Lewis, Erin D, Ortega, Edwin F, Dao, Maria Carlota, Barger, Kathryn, Mason, Joel B, Leong, John M, Osburne, Marcia S, Magoun, Loranne, Nepveux, Felix J, Chishti, Athar H, Schwake, Christopher, Quynh, Anh, Gilhooly, Cheryl H, Petty, Gayle, Guo, Weimin, Matuszek, Gregory, Pereira, Dora, Reddy, Manju, Wang, Jifan, Wu, Dayong, Meydani, Simin N, Combs, Jr, Gerald F

“…[This corrects the article DOI: 10.3389/fnut.2023.1230061.]…”
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Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial - the safe iron study by Lewis, Erin D, Ortega, Edwin F, Dao, Maria Carlota, Barger, Kathryn, Mason, Joel B, Leong, John M, Osburne, Marcia S, Magoun, Loranne, Nepveux V, Felix J, Chishti, Athar H, Schwake, Christopher, Quynh, Anh, Gilhooly, Cheryl H, Petty, Gayle, Guo, Weimin, Matuszek, Gregory, Pereira, Dora, Reddy, Manju, Wang, Jifan, Wu, Dayong, Meydani, Simin N, Combs, Jr, Gerald F

“…The safety of novel forms of iron in healthy, iron-replete adults as might occur if used in population-based iron supplementation programs was examined. We…”
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Band 3 Is a Host Receptor Binding Merozoite Surface Protein 1 during the Plasmodium falciparum Invasion of Erythrocytes by Goel, Vikas K., Li, Xuerong, Chen, Huiqing, Liu, Shih-Chun, Chishti, Athar H., Oh, Steven S.

“…We report the molecular identification of a sialic acid-independent host-parasite interaction in the Plasmodium falciparum malaria parasite invasion of RBCs…”
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Erythrocyte Scaffolding Protein p55/MPP1 Functions as an Essential Regulator of Neutrophil Polarity by Quinn, Brendan J., Welch, Emily J., Kim, Anthony C., Lokuta, Mary A., Huttenlocher, Anna, Khan, Anwar A., Kuchay, Shafi M., Chishti, Athar H.

“…As mediators of innate immunity, neutrophils respond to chemoattractants by adopting a highly polarized morphology. Efficient chemotaxis requires the formation…”
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The Headpiece Domain of Dematin Regulates Cell Shape, Motility, and Wound Healing by Modulating RhoA Activation by Mohseni, Morvarid, Chishti, Athar H.

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Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections by Schwake, Christopher, Hyon, Michael, Chishti, Athar H

“…Signal peptide peptidase (SPP) is a GxGD-type intramembrane-cleaving aspartyl protease responsible for clearing accumulating signal peptides in the endoplasmic…”
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Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development by Hanspal, Manjit, Dua, Meenakshi, Takakuwa, Yuichi, Chishti, Athar H., Mizuno, Akiko

“…Plasmodium falciparum–derived cysteine protease falcipain-2 cleaves host erythrocyte hemoglobin at acidic pH and specific components of the membrane skeleton…”
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Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes by Schwake, Christopher J, Krueger, Rachel M, Hanada, Toshihiko, Chishti, Athar H

“…Plasmodium falciparum glutamic acid-rich protein (PfGARP) is a recently characterized cell surface antigen encoded by Plasmodium falciparum, the causative…”
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BDA‐410 inhibits SARS‐CoV‐2 main protease activity and viral replication in mammalian cells by Schwake, Christopher, McKay, Lindsay, Griffiths, Anthony, Scartelli, Christina, Flaumenhaft, Robert, Chishti, Athar H.

“…Of interest, there are two predicted stabilizing hydrogen bonds between BDA-410 and the catalytic residue CYS145 due to proximity of hydrogen bonding…”
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