Search Results - "H. Brown"

Talin - the master of integrin adhesions by Klapholz, Benjamin, Brown, Nicholas H

“…Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellular matrix. In this Review, we draw on experiments performed…”
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Estimating the global prevalence of zinc deficiency: results based on zinc availability in national food supplies and the prevalence of stunting by Wessells, K Ryan, Brown, Kenneth H

“…Adequate zinc nutrition is essential for adequate growth, immunocompetence and neurobehavioral development, but limited information on population zinc status…”
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Decoding ALS: from genes to mechanism by Taylor, J. Paul, Brown, Robert H., Cleveland, Don W.

“…Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative disease. A plethora of genetic factors have been identified that…”
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On the Distribution of Protein Refractive Index Increments by Zhao, Huaying, Brown, Patrick H., Schuck, Peter

“…The protein refractive index increment, dn/dc, is an important parameter underlying the concentration determination and the biophysical characterization of…”
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Targeting phospholipase D in cancer, infection and neurodegenerative disorders by Brown, H. Alex, Thomas, Paul G., Lindsley, Craig W.

“…Key Points Phospholipase D (PLD) enzymes are one source of receptor-generated phosphatidic acid (PtdOH),which may subsequently be metabolized to diacylglycerol…”
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Emerging mechanisms of molecular pathology in ALS by Peters, Owen M, Ghasemi, Mehdi, Brown, Jr, Robert H

“…Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease characterized by progressive loss of motor neurons in the motor cortex, brainstem,…”
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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons by Wainger, Brian J, Kiskinis, Evangelos, Mellin, Cassidy, Wiskow, Ole, Han, Steve S W, Sandoe, Jackson, Perez, Numa P, Williams, Luis A, Lee, Seungkyu, Boulting, Gabriella, Berry, James D, Brown, Jr, Robert H, Cudkowicz, Merit E, Bean, Bruce P, Eggan, Kevin, Woolf, Clifford J

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp…”
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Amyotrophic lateral sclerosis: Problems and prospects by Sreedharan, Jemeen, Brown Jr, Robert H.

“…Amyotrophic lateral sclerosis (ALS) is a lethal degenerative disorder of motoneurons, which may occur concurrently with frontotemporal dementia. Genetic…”
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Advances in therapeutic peptides targeting G protein-coupled receptors by Davenport, Anthony P., Scully, Conor C. G., de Graaf, Chris, Brown, Alastair J. H., Maguire, Janet J.

“…Dysregulation of peptide-activated pathways causes a range of diseases, fostering the discovery and clinical development of peptide drugs. Many endogenous…”
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Plant nutrition for sustainable development and global health by White, P.J, Brown, P.H

“…BACKGROUND: Plants require at least 14 mineral elements for their nutrition. These include the macronutrients nitrogen (N), phosphorus (P), potassium (K),…”
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Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer by Bruntz, Ronald C, Lindsley, Craig W, Brown, H Alex

“…Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an intracellular signaling species. The phospholipase D superfamily plays…”
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Biostimulants in Plant Science: A Global Perspective by Yakhin, Oleg I, Lubyanov, Aleksandr A, Yakhin, Ildus A, Brown, Patrick H

“…This review presents a comprehensive and systematic study of the field of plant biostimulants and considers the fundamental and innovative principles…”
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Understanding how race/ethnicity and gender define age-trajectories of disability: An intersectionality approach by Warner, David F., Brown, Tyson H.

“…A number of studies have demonstrated wide disparities in health among racial/ethnic groups and by gender, yet few have examined how race/ethnicity and gender…”
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Frailty, Aging, and Cardiovascular Surgery by Graham, Antonio, Brown, Charles H

“…Older adults make up an ever-increasing number of patients presenting for surgery, and a significant percentage of these patients will be frail. Frailty is a…”
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Molecular biology of amyotrophic lateral sclerosis: insights from genetics by Pasinelli, Piera, Brown, Robert H

“…Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron degeneration. Mutations in more than 50 human genes cause diverse types of…”
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State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018 by Mahanna-Gabrielli, Elizabeth, Schenning, Katie J, Eriksson, Lars I, Browndyke, Jeffrey N, Wright, Clinton B, Culley, Deborah J, Evered, Lis, Scott, David A, Wang, Nae Yah, Brown, 4th, Charles H, Oh, Esther, Purdon, Patrick, Inouye, Sharon, Berger, Miles, Whittington, Robert A, Price, Catherine C, Deiner, Stacie

“…Cognitive recovery after anaesthesia and surgery is a concern for older adults, their families, and caregivers. Reports of patients who were 'never the same'…”
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From plant surface to plant metabolism: the uncertain fate of foliar-applied nutrients by Fernández, Victoria, Brown, Patrick H

“…The application of agrochemical sprays to the aerial parts of crop plants is an important agricultural practice world-wide. While variable effectiveness is…”
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Retinoids and Rexinoids in Cancer Prevention: From Laboratory to Clinic by Uray, Iván P., M.D., Ph.D, Dmitrovsky, Ethan, M.D, Brown, Powel H., M.D., Ph.D

“…Early in the age of modern medicine the consequences of vitamin A deficiency drew attention to the fundamental link between retinoid-dependent homeostatic…”
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Ecological roles and conservation challenges of social, burrowing, herbivorous mammals in the world's grasslands by Davidson, Ana D, Detling, James K, Brown, James H

“…The world's grassland ecosystems are shaped in part by a key functional group of social, burrowing, herbivorous mammals. Through herbivory and ecosystem…”
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Diversity and Function of Capsular Polysaccharide in Acinetobacter baumannii by Singh, Jennifer K, Adams, Felise G, Brown, Melissa H

“…The Gram-negative opportunistic bacterium is a significant cause of hospital-borne infections worldwide. Alarmingly, the rapid development of antimicrobial…”
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