Search Results - "H T Keutmann"

Structural Organization of the Nine Spectrin Repeats of Kalirin by Vishwanatha, K. S, Wang, Y. P, Keutmann, H. T, Mains, R. E, Eipper, B. A

“…Sequence analysis suggests that KALRN, a Rho GDP/GTP exchange factor genetically linked to schizophrenia, could contain as many as nine tandem spectrin repeats…”
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The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34) by Jüppner, H, Schipani, E, Bringhurst, F R, McClure, I, Keutmann, H T, Potts, Jr, J T, Kronenberg, H M, Abou-Samra, A B, Segre, G V, Gardella, T J

“…The recombinant human PTH/PTH-related peptide (PTHrP) receptor, when transiently expressed in COS-7 cells, binds [Nle8,18,Tyr34] bovine PTH-(7-34)amide…”
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Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia by Nussbaum, S R, Zahradnik, R J, Lavigne, J R, Brennan, G L, Nozawa-Ung, K, Kim, L Y, Keutmann, H T, Wang, C A, Potts, Jr, J T, Segre, G V

“…We have developed a highly sensitive, two-site immunoradiometric assay (IRMA) for human parathyrin (PTH) that is specific for the intact, secreted,…”
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The glycoprotein hormones: recent studies of structure-function relationships by Ryan, R J, Charlesworth, M C, McCormick, D J, Milius, R P, Keutmann, H T

“…The structural features of the heterodimeric glycoprotein hormones (LH, FSH, TSH, and hCG) are briefly reviewed. Removal of carbohydrate chains does not reduce…”
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Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM) by EIPPER, B. A, GREEN, C. B.-R, CAMPBELL, T. A, STOFFERS, D. A, KEUTMANN, H. T, MAINS, R. E, OUAFIK, H

“…The pituitary is a rich source of peptidylglycine alpha-amidating monooxygenase (PAM). This bifunctional protein contains peptidylglycine alpha-hydroxylating…”
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A Receptor-Binding Region in Human Choriogonadotropin/Lutropin β Subunit by Keutmann, Henry T., Charlesworth, M. Cristine, Mason, Kathleen A., Ostrea, Teofila, Johnson, Leslie, Ryan, Robert J.

“…Synthetic fragments have not been widely used thus far to evaluate structure-activity relations in the glycoprotein hormones. We prepared a series of peptides…”
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Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine alpha-amidating monooxygenase by HUSTEN, E. J, TAUSK, F. A, KEUTMANN, H. T, EIPPER, B. A

“…The production of alpha-amidated peptides is accomplished through the sequential action of two enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM)…”
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Mutational analysis of the receptor-activating region of human parathyroid hormone by T J Gardella, D Axelrod, D Rubin, H T Keutmann, J T Potts, Jr, H M Kronenberg, S R Nussbaum

“…The first 4 residues of parathyroid hormone (PTH) are highly conserved in evolution and are important for biological activity. We randomly mutated codons 1-4…”
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Peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Purification, characterization, and expression by Eipper, B A, Perkins, S N, Husten, E J, Johnson, R C, Keutmann, H T, Mains, R E

“…The production of alpha-amidated peptides from their glycine-extended precursors is a two-step process involving the sequential action of two catalytic domains…”
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Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase by HYE-YOUNG YUN, KEUTMANN, H. T, EIPPER, B. A

“…Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-terminal alpha-amidation of neuro-endocrine peptides through the sequential action of…”
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Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design by Gardella, T J, Wilson, A K, Keutmann, H T, Oberstein, R, Potts, Jr, J T, Kronenberg, M, Nussbaum, S R

“…Previous deletion studies established that the 25-34 region of PTH is important for receptor binding. We used oligonucleotide-directed mutagenesis to generate…”
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Developmental regulation of peptidylglycine alpha-amidating monooxygenase (PAM) in rat heart atrium and ventricle. Tissue-specific changes in distribution of PAM activity, mRNA levels, and protein forms by Ouafik, L, May, V, Keutmann, H T, Eipper, B A

“…The high levels of peptidylglycine alpha-amidating monooxygenase (PAM, EC 1.14.17.3) found in adult rat atrium led us to examine PAM expression in rat atrium…”
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Receptor-binding regions in human glycoprotein hormones by Keutmann, H T

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α-Enolase is restricted to basal cells of stratified squamous epithelium by Zieske, James D., Bukusoglu, Gül, Yankauckas, Michelle A., Wasson, Michael E., Keutmann, Henry T.

“…We have developed a monoclonal antibody against a 50-kDa protein that binds preferentially to basal cells in the limbus of rat, rabbit, and human corneas (J…”
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Amidation of joining peptide, a major pro-ACTH/endorphin-derived product peptide by Eipper, B A, Park, L, Keutmann, H T, Mains, R E

“…Based on sequence data, rat and mouse pro-adrenocorticotropin (ACTH)/endorphin could give rise to joining peptide, a short acidic peptide that could terminate…”
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Intracellular and Extracellular Processing of Human Apolipoprotein A-I: Secreted Apolipoprotein A-I Isoprotein 2 is a Propeptide by Zannis, V. I., Karathanasis, S. K., Keutmann, H. T., Goldberger, G., Breslow, J. L.

“…We have recently proposed that the major secreted isoprotein form of human apolipoprotein A-I (designated apo A-I2) is modified extracellularly to become the…”
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Architectural Rules of the Zinc-Finger Motif: Comparative Two-Dimensional NMR Studies of Native and "Aromatic-Swap" Domains Define a "Weakly Polar Switch" by Kochoyan, Michel, Keutmann, Henry T., Weiss, Michael A.

“…The Zn-finger motif, encoding a globular minidomain with characteristic structure, provides a striking example of a sequence template for protein folding…”
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Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein by T J Gardella, D Rubin, A B Abou-Samra, H T Keutmann, J T Potts, Jr, H M Kronenberg, S R Nussbaum

“…Recombinant human parathyroid hormone (hPTH)-(1-84) was obtained from Escherichia coli using a cleavable fusion protein strategy. The fusion protein contains…”
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A receptor binding site identified in the region 81-95 of the beta-subunit of human luteinizing hormone (LH) and chorionic gonadotropin (hCG) by Morbeck, D E, Roche, P C, Keutmann, H T, McCormick, D J

“…Two series of overlapping peptides comprising the entire sequences of the beta-subunits of human lutropin (LH) and choriogonadotropin (hCG) were prepared by a…”
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Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for jumping-linker DNA recognition by Kochoyan, Michel, Havel, Timothy F, Nguyen, Dzung T, Dahl, Charles E, Keutmann, Henry T, Weiss, Michael A

“…ZFY, a sex-related Zn-finger protein encoded by the human Y chromosome, is distinguished from the general class of Zn-finger proteins by the presence of a…”
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