Search Results - "H Rabbad, Ali"
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Structural Insights into the Role of Pseudouridimycin Binding in Disruption of Bacterial RNA Polymerase Bridge Helix Conformational Arrangement
Published in Current pharmaceutical biotechnology (01-01-2023)“…The bridge helix (BH) is a crucial region in bacterial RNA polymerase (RNAP) catalysis. It plays an essential role in the nucleotide addition cycle (NAC) by…”
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PCSK9 inhibitors as safer therapeutics for atherosclerotic cardiovascular disease (ASCVD): Pharmacophore design and molecular dynamics analysis
Published in Journal of cellular biochemistry (01-07-2024)“…Cardiovascular disorders are still challenging and are among the deadly diseases. As a major risk factor for atherosclerotic cardiovascular disease,…”
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Journal Article -
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Monastrol disrupts KIFC1-ATP dynamics: Towards newer anticancer mechanism
Published in Chemical physics impact (01-06-2024)“…Mitotic kinesins are eukaryotic proteins that play a vital role in cellular mitosis. Their over-expression in malignant rather than normal cells and their…”
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Microbes, not humans: exploring the molecular basis of Pseudouridimycin selectivity towards bacterial and not human RNA polymerase
Published in Biotechnology letters (01-01-2019)“…Objective Bacterial RNA polymerase (bRNAP) represent a crucial target for curtailing microbial activity but its structural and sequence similarities with human…”
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Journal Article