Search Results - "H Lerat"

A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change by Ulfhake, B, Lerat, H, Honetschlager, J, Pernold, K, Rynekrová, M, Escot, K, Recordati, C, Kuiper, R V, Rosati, G, Rigamonti, M, Zordan, S, Prins, J-B

“…Mice respond to a cage change (CC) with altered activity, disrupted sleep and increased anxiety. A bi-weekly cage change is, therefore, preferred over a…”
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Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events by Higgs, M R, Lerat, H, Pawlotsky, J-M

“…Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying…”
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P0673 : Pathophysiology of HCV-related hepatocellular carcinoma: HCV protein expression induces the activation of AKT1 in hepatocytes through an mTORC2 dependent pathway by Imache, M.-R, Polyte, J, Pawlotsky, J.-M, Lerat, H

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Apico-basal polarity in epithelial cell morphogenesis and liver pathogenesis by Hamze-Komaiha, O, El Harake, M, Benzoubir, N, Awad, A, Mercey, M, Lerat, H, Samuel, D, Gassama, A

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P0671 : Mechanisms of HCV-induced diabetes through impaired insulin-driven gluconeogenesis shut-down by HCV proteins as a result of uncoupling of FoxO1/AKT signaling by Lerat, H, Polyte, J, Gaudin, A, Imache, M.-R, Magnan, C, Foufelle, F, Pawlotsky, J.-M

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1164 INDUCTION OF A PREDIABETIC STATE IN TRANSGENIC MICE EXPRESSING THE HCV PROTEINS by Lerat, H, Gaudin, A, Blondeau, B, Foufelle, F, Magnan, C, Pawlotsky, J.-M

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282 CELL CYCLE DEREGULATION BY HCV PROTEIN EXPRESSION, A POTENTIAL HEPATOCARCINOGENIC TRIGGER by Florimond, A, Chouteau, P, Defer, N, Gaudin, A, Lerat, H, Pawlotsky, J.-M

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854 REGULATION OF HEPATITIS C VIRUS REPLICATION BY NUCLEAR TRANSLOCATION OF NONSTRUCTURAL 5A PROTEIN AND TRANSCRIPTIONAL ACTIVATION OF HOST GENES by Maqbool, M.A, Higgs, M, Pawlotsky, J.-M, Lerat, H

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874 EPIGENETIC MODULATION OF TUMOUR SUPPRESSOR GADD45 BETA EXPRESSION BY HCV LEADS TO DEFECTIVE CELL CYCLE ARREST AND MAY PLAY A ROLE IN LIVER CARCINOGENESIS by Higgs, M, Lerat, H, Pawlotsky, J.-M

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659 HCV NS5A PROTEIN BEARS TRANSACTIVATION PROPERTIES THAT CORRELATE WITH HCV REPLICATION CAPACITY IN VITRO by Maqbool, M.A, Lerat, H, Pawlotsky, J.M

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The Hepatitis C Virus NS2 Protein Is an Inhibitor of CIDE-B-induced Apoptosis by Erdtmann, Lars, Franck, Nathalie, Lerat, Hervé, Le Seyec, Jacques, Gilot, David, Cannie, Isabelle, Gripon, Philippe, Hibner, Urszula, Guguen-Guillouzo, Christiane

“…Chronic hepatitis C virus (HCV) infection frequently leads to liver cancer. To determine the viral factor(s) potentially involved in viral persistence, we…”
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Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells by Lerat, H, Berby, F, Trabaud, M A, Vidalin, O, Major, M, Trépo, C, Inchauspé, G

“…The presence of hepatitis C virus (HCV) negative strand RNA in extrahepatic compartments based on PCR detection assays has been suggested in many reports with…”
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853 HEPATITIS C VIRUS-INDUCED ACTIVATION OF BETA-CATENIN VIA THE AKT PATHWAY PROMOTES C-MYC EXPRESSION AND A CASCADE OF PRO-CARCINOGENETIC EVENTS by Higgs, M.R, Lerat, H, Pawlotsky, J.-M

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[16] MECHANISMS OF HEPATITIS C VIRUS (HCV)-INDUCED HEPATIC STEATOSIS IN TRANSGENIC MICE by Lerat, H, Foufelle, F, Pawlotsky, I.-M

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Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein by Disson, Olivier, Haouzi, Delphine, Desagher, Solange, Loesch, Kim, Hahne, Michael, Kremer, Eric J., Jacquet, Chantal, Lemon, Stanley M., Hibner, Urszula, Lerat, Hervé

“…Background & Aims : Multiple molecular mechanisms are likely to contribute to the establishment of persistent infection by hepatitis C virus (HCV). The aim of…”
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222 PROMOTION OF LIVER CARCINOGENESIS BY HEPATITIS C VIRUS THROUGH ENHANCED C-MYC EXPRESSION, LEADING TO DNA DAMAGE AND OXIDATIVE STRESS by Higgs, M, Lerat, H, Pawlotsky, J.-M

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77 FUNCTIONAL COMPARTMENTALIZATION OF HCV NS5A VARIANTS WITHIN THE TUMORAL AND NON-TUMORAL TISSUE FROM PATIENTS WITH HEPATOCELLULAR CARCINOMA by Lerat, H, Carmouse, S, Pellerin, M, Zucman-Rossi, J, Pawlotsky, J.M

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Fundamental and translational research on hepatocellular carcinoma in 2008: forces and priorities by Zucman-Rossi, J, Clément, B, Buendia, M-A, Lerat, H, Beers, B Van, Bedossa, P, Taieb, J, Rosenbaum, J

“…Hepatocellular carcinogenesis is usually the result of a muti-step process. It begins with an exposure to various risk factors; followed by the development of…”
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Hepatocytes Transgenic for the Full Hepatitis C Virus Open Reading Frame Are Resistant to Fas-Induced Cell Death by DISSON, OLIVIER, HAHNE, MICHAEL, HIBNER, URSZULA, LERAT, HERVÉ

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A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans by Lemon, S M, Lerat, H, Weinman, S A, Honda, M

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