Search Results - "Hürlimann, M."

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter by Hohl, Michael, Hürlimann, Lea M., Böhm, Simon, Schöppe, Jendrik, Grütter, Markus G., Bordignon, Enrica, Seeger, Markus A.

“…ATP binding cassette (ABC) transporters mediate vital transport processes in every living cell. ATP hydrolysis, which fuels transport, displays positive…”
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The extracellular gate shapes the energy profile of an ABC exporter by Hutter, Cedric A. J., Timachi, M. Hadi, Hürlimann, Lea M., Zimmermann, Iwan, Egloff, Pascal, Göddeke, Hendrik, Kucher, Svetlana, Štefanić, Saša, Karttunen, Mikko, Schäfer, Lars V., Bordignon, Enrica, Seeger, Markus A.

“…ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but…”
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Deep mutational scan of a drug efflux pump reveals its structure–function landscape by Meier, Gianmarco, Thavarasah, Sujani, Ehrenbolger, Kai, Hutter, Cedric A. J., Hürlimann, Lea M., Barandun, Jonas, Seeger, Markus A.

“…Drug efflux is a common resistance mechanism found in bacteria and cancer cells, but studies providing comprehensive functional insights are scarce. In this…”
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The ABC exporter IrtAB imports and reduces mycobacterial siderophores by Arnold, Fabian M., Weber, Miriam S., Gonda, Imre, Gallenito, Marc J., Adenau, Sophia, Egloff, Pascal, Zimmermann, Iwan, Hutter, Cedric A. J., Hürlimann, Lea M., Peters, Eike E., Piel, Jörn, Meloni, Gabriele, Medalia, Ohad, Seeger, Markus A.

“…Intracellular replication of the deadly pathogen Mycobacterium tuberculosis relies on the production of small organic molecules called siderophores that…”
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Biomolecules capturing live bacteria from clinical samples by Sorgenfrei, Michèle, Hürlimann, Lea M., Remy, Mélissa M., Keller, Peter M., Seeger, Markus A.

“…Rapid phenotypic antimicrobial susceptibility testing (AST) requires the enrichment of live bacteria from patient samples, which is particularly challenging in…”
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Results and experiences gathered at the Rebaixader debris-flow monitoring site, Central Pyrenees, Spain by Hürlimann, M., Abancó, C., Moya, J., Vilajosana, I.

“…The wired and wireless monitoring system installed in the Rebaixader catchment detected six debris flows and 11 debris floods between 2009 and 2012. Apart from…”
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The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis by Hürlimann, Lea M, Corradi, Valentina, Hohl, Michael, Bloemberg, Guido V, Tieleman, D Peter, Seeger, Markus A

“…Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are…”
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Split tasks of asymmetric nucleotide‐binding sites in the heterodimeric ABC exporter EfrCD by Hürlimann, Lea M., Hohl, Michael, Seeger, Markus A.

“…Many heterodimeric ATP‐binding cassette (ABC) exporters evolved asymmetric ATP‐binding sites containing a degenerate site incapable of ATP hydrolysis due to…”
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Field and monitoring data of debris-flow events in the Swiss Alps by Hürlimann, M, Rickenmann, D, Graf, C

“…Debris flow is a common process in the Swiss Alps and in other mountainous parts of the world. The understanding of debris-flow behaviour is essential to…”
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Debris-flow forecasting at regional scale by combining susceptibility mapping and radar rainfall by Berenguer, M, Sempere-Torres, D, Hürlimann, M

“…This work presents a technique for debris-flow (DF) forecasting able to be used in the framework of DF early warning systems at regional scale. The developed…”
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Quantitative Measurement of Two-Dimensional Distribution Functions of Diffusion and Relaxation in Grossly Inhomogeneous Fields by Hürlimann, M.D, Venkataramanan, L

“…We demonstrate the quantitative extraction of multidimensional distribution functions in the presence of grossly inhomogeneous fields. Examples are shown for…”
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Biotinylation of Membrane Proteins for Binder Selections by Kuhn, Benedikt T, Zimmermann, Iwan, Egloff, Pascal, Hürlimann, Lea M, Hutter, Cedric A J, Miscenic, Christian, Dawson, Roger J P, Seeger, Markus A, Geertsma, Eric R

“…The selective immobilization of proteins represents an essential step in the selection of binding proteins such as antibodies. The immobilization strategy…”
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Real-time optimization of nuclear magnetic resonance experiments by Song, Y.-Q., Tang, Yiqiao, Hürlimann, M.D., Cory, D.G.

“…[Display omitted] •Dynamic optimization for NMR automation.•Requires knowledge of signal model of the experiment.•Does not require prior knowledge of pulse…”
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An ultra-broadband low-frequency magnetic resonance system by Mandal, S., Utsuzawa, S., Cory, D.G., Hürlimann, M., Poitzsch, M., Song, Y.-Q.

“…[Display omitted] •Describes an ultra-broadband low-frequency MR system using an un-tuned sample coil.•Similar sensitivity to tuned systems over a wide…”
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Analysis of the ground vibration generated by debris flows and other torrential processes at the Rebaixader monitoring site (Central Pyrenees, Spain) by Abancó, C, Hürlimann, M, Moya, J

“…Monitoring of debris flows using ground vibration sensors has increased in the last two decades. However, the correct interpretation of the signals still…”
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Processing the ground vibration signal produced by debris flows: the methods of amplitude and impulses compared by Arattano, M., Abancó, C., Coviello, V., Hürlimann, M.

“…Ground vibration sensors have been increasingly used and tested, during the last few years, as devices to monitor debris flows and they have also been proposed…”
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A rapid measurement of T1/T2: the DECPMG sequence by Mitchell, J, Hürlimann, M D, Fordham, E J

“…The Driven-Equilibrium Carr-Purcell Meiboom-Gill (DECPMG) pulse sequence is a rapid method for obtaining the average ratio of longitudinal to transverse…”
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Diffusion and Relaxation Effects in General Stray Field NMR Experiments by Hürlimann, M.D.

“…We analyze the evolution of magnetization following any series of radiofrequency pulses in strongly inhomogeneous fields, with particular attention to…”
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A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter by Bukowska, Magdalena A, Hohl, Michael, Geertsma, Eric R, Hürlimann, Lea M, Grütter, Markus G, Seeger, Markus A

“…ABC exporters are ubiquitous multidomain transport proteins that couple ATP hydrolysis at a pair of nucleotide binding domains to substrate transport across…”
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Evolution of the north flank of Tenerife by recurrent giant landslides by Ablay, G, Hürlimann, M

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