Search Results - "Hünniger, Kerstin"

A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood by Hünniger, Kerstin, Lehnert, Teresa, Bieber, Kristin, Martin, Ronny, Figge, Marc Thilo, Kurzai, Oliver

“…Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the…”
Get full text

Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions by Lehnert, Teresa, Leonhardt, Ines, Timme, Sandra, Thomas-Rüddel, Daniel, Bloos, Frank, Sponholz, Christoph, Kurzai, Oliver, Figge, Marc Thilo, Hünniger, Kerstin

“…The assessment of a patient’s immune function is critical in many clinical situations. In complex clinical immune dysfunction like sepsis, which results from a…”
Get full text

Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity by Häder, Antje, Schäuble, Sascha, Gehlen, Jan, Thielemann, Nadja, Buerfent, Benedikt C., Schüller, Vitalia, Hess, Timo, Wolf, Thomas, Schröder, Julia, Weber, Michael, Hünniger, Kerstin, Löffler, Jürgen, Vylkova, Slavena, Panagiotou, Gianni, Schumacher, Johannes, Kurzai, Oliver

“…Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals…”
Get full text

A core filamentation response network in Candida albicans is restricted to eight genes by Martin, Ronny, Albrecht-Eckardt, Daniela, Brunke, Sascha, Hube, Bernhard, Hünniger, Kerstin, Kurzai, Oliver

“…Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms…”
Get full text

Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes by Duggan, Seána, Essig, Fabian, Hünniger, Kerstin, Mokhtari, Zeinab, Bauer, Laura, Lehnert, Teresa, Brandes, Susanne, Häder, Antje, Jacobsen, Ilse D, Martin, Ronny, Figge, Marc Thilo, Kurzai, Oliver

“…Summary Candida albicans and Candida glabrata account for the majority of candidiasis cases worldwide. Although both species are in the same genus, they differ…”
Get full text

COVID-19 patients share common, corticosteroid-independent features of impaired host immunity to pathogenic molds by Tappe, Beeke, Lauruschkat, Chris D., Strobel, Lea, Pantaleón García, Jezreel, Kurzai, Oliver, Rebhan, Silke, Kraus, Sabrina, Pfeuffer-Jovic, Elena, Bussemer, Lydia, Possler, Lotte, Held, Matthias, Hünniger, Kerstin, Kniemeyer, Olaf, Schäuble, Sascha, Brakhage, Axel A., Panagiotou, Gianni, White, P. Lewis, Einsele, Hermann, Löffler, Jürgen, Wurster, Sebastian

“…Patients suffering from coronavirus disease-2019 (COVID-19) are susceptible to deadly secondary fungal infections such as COVID-19-associated pulmonary…”
Get full text

Comparative assessment of immune evasion mechanisms in human whole-blood infection assays by a systems biology approach by Lehnert, Teresa, Prauße, Maria T E, Hünniger, Kerstin, Praetorius, Jan-Philipp, Kurzai, Oliver, Figge, Marc Thilo

“…Computer simulations of mathematical models open up the possibility of assessing hypotheses generated by experiments on pathogen immune evasion in human…”
Get full text

Automated tracking of label-free cells with enhanced recognition of whole tracks by Al-Zaben, Naim, Medyukhina, Anna, Dietrich, Stefanie, Marolda, Alessandra, Hünniger, Kerstin, Kurzai, Oliver, Figge, Marc Thilo

“…Migration and interactions of immune cells are routinely studied by time-lapse microscopy of in vitro migration and confrontation assays. To objectively…”
Get full text

Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans by Ruben, Sophia, Garbe, Enrico, Mogavero, Selene, Albrecht-Eckardt, Daniela, Hellwig, Daniela, Häder, Antje, Krüger, Thomas, Gerth, Katrin, Jacobsen, Ilse D, Elshafee, Osama, Brunke, Sascha, Hünniger, Kerstin, Kniemeyer, Olaf, Brakhage, Axel A, Morschhäuser, Joachim, Hube, Bernhard, Vylkova, Slavena, Kurzai, Oliver, Martin, Ronny

“…The capacity of to reversibly change its morphology between yeast and filamentous stages is crucial for its virulence. Formation of hyphae correlates with the…”
Get full text

C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function by Kiehntopf, Michael, Imhof, Diana, Baier, Michael, Ludewig, Katrin, Kurzai, Oliver, Hünniger, Kerstin, Schmerler, Diana, Blaurock, Nancy, Brunkhorst, Frank Martin

“…Systemic inflammatory response syndrome (SIRS) is a life threatening condition and the leading cause of death in intensive care units. Although single aspects…”
Get full text

Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood by Prauße, Maria T E, Lehnert, Teresa, Timme, Sandra, Hünniger, Kerstin, Leonhardt, Ines, Kurzai, Oliver, Figge, Marc Thilo

“…Bloodstream infections by the human-pathogenic fungi and increasingly occur in hospitalized patients and are associated with high mortality rates. The early…”
Get full text

The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity by Leonhardt, Ines, Spielberg, Steffi, Weber, Michael, Albrecht-Eckardt, Daniela, Bläss, Markus, Claus, Ralf, Barz, Dagmar, Scherlach, Kirstin, Hertweck, Christian, Löffler, Jürgen, Hünniger, Kerstin, Kurzai, Oliver

“…Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of…”
Get full text

Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood by Machata, Silke, Sreekantapuram, Sravya, Hünniger, Kerstin, Kurzai, Oliver, Dunker, Christine, Schubert, Katja, Krüger, Wibke, Schulze-Richter, Bianca, Speth, Cornelia, Rambach, Günter, Jacobsen, Ilse D

“…Murine infection models are widely used to study systemic candidiasis caused by . Whole-blood models can help to elucidate host-pathogens interactions and have…”
Get full text

Automated characterisation of neutrophil activation phenotypes in ex vivo human Candida blood infections by Belyaev, Ivan, Marolda, Alessandra, Praetorius, Jan-Philipp, Sarkar, Arjun, Medyukhina, Anna, Hünniger, Kerstin, Kurzai, Oliver, Figge, Marc Thilo

“…[Display omitted] •Candida bloodstream infections are difficult to diagnose and treat in humans.•Infection processes give rise to activation of host immune…”
Get full text

Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal Pathogen Aspergillus fumigatus by Weiss, Esther, Schlegel, Jan, Terpitz, Ulrich, Weber, Michael, Linde, Jörg, Schmitt, Anna-Lena, Hünniger, Kerstin, Marischen, Lothar, Gamon, Florian, Bauer, Joachim, Löffler, Claudia, Kurzai, Oliver, Morton, Charles Oliver, Sauer, Markus, Einsele, Hermann, Loeffler, Juergen

“…Delayed natural killer (NK) cell reconstitution after allogeneic stem cell transplantation (alloSCT) is associated with a higher risk of developing invasive…”
Get full text

Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection by Beitzen-Heineke, Antonia, Bouzani, Maria, Schmitt, Anna-Lena, Kurzai, Oliver, Hünniger, Kerstin, Einsele, Hermann, Loeffler, Juergen

“…Aspergillus fumigatus is the most common cause for invasive fungal infections, a disease associated with high mortality in immune-compromised patients…”
Get full text

Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients by Timme, Sandra, Lehnert, Teresa, Prauße, Maria T E, Hünniger, Kerstin, Leonhardt, Ines, Kurzai, Oliver, Figge, Marc Thilo

“…The condition of neutropenia, i.e., a reduced absolute neutrophil count in blood, constitutes a major risk factor for severe infections in the affected…”
Get full text

First Insights in NK-DC Cross-Talk and the Importance of Soluble Factors During Infection With Aspergillus fumigatus by Weiss, Esther, Ziegler, Sabrina, Fliesser, Mirjam, Schmitt, Anna-Lena, Hünniger, Kerstin, Kurzai, Oliver, Morton, Charles-Oliver, Einsele, Hermann, Loeffler, Juergen

“…Invasive aspergillosis (IA) is an infectious disease caused by the fungal pathogen that mainly affects immunocompromised hosts. To investigate immune cell…”
Get full text

Isoform localization of Dectin‐1 regulates the signaling quality of anti‐fungal immunity by Fischer, Mike, Müller, Jörg P., Spies‐Weisshart, Bärbel, Gräfe, Christine, Kurzai, Oliver, Hünniger, Kerstin, Hochhaus, Andreas, Scholl, Sebastian, Schnetzke, Ulf

“…Dectin‐1 is recognized as a major receptor for fungal ß‐glucans and contributes to anti‐fungal immunity. Human monocyte populations express Dectin‐1 isoforms A…”
Get full text

Phagocytes as central players in the defence against invasive fungal infection by Hünniger, Kerstin, Kurzai, Oliver

“…Fungal pathogens cause severe and life-threatening infections worldwide. The majority of invasive infections occurs in immunocompromised patients and is based…”
Get full text