Search Results - "Hübschmann, Daniel"

simplifyEnrichment: A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results by Gu, Zuguang, Hübschmann, Daniel

“…Functional enrichment analysis or gene set enrichment analysis is a basic bioinformatics method that evaluates the biological importance of a list of genes of…”
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Improve consensus partitioning via a hierarchical procedure by Gu, Zuguang, Hübschmann, Daniel

“…Abstract Consensus partitioning is an unsupervised method widely used in high-throughput data analysis for revealing subgroups and assigning stability for the…”
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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states by Triana, Sergio, Vonficht, Dominik, Jopp-Saile, Lea, Raffel, Simon, Lutz, Raphael, Leonce, Daniel, Antes, Magdalena, Hernández-Malmierca, Pablo, Ordoñez-Rueda, Diana, Ramasz, Beáta, Boch, Tobias, Jann, Johann-Christoph, Nowak, Daniel, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Hübschmann, Daniel, Alexandrov, Theodore, Benes, Vladimir, Trumpp, Andreas, Paulsen, Malte, Velten, Lars, Haas, Simon

“…Single-cell genomics technology has transformed our understanding of complex cellular systems. However, excessive cost and a lack of strategies for the…”
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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis by Körber, Verena, Yang, Jing, Barah, Pankaj, Wu, Yonghe, Stichel, Damian, Gu, Zuguang, Fletcher, Michael Nai Chung, Jones, David, Hentschel, Bettina, Lamszus, Katrin, Tonn, Jörg Christian, Schackert, Gabriele, Sabel, Michael, Felsberg, Jörg, Zacher, Angela, Kaulich, Kerstin, Hübschmann, Daniel, Herold-Mende, Christel, von Deimling, Andreas, Weller, Michael, Radlwimmer, Bernhard, Schlesner, Matthias, Reifenberger, Guido, Höfer, Thomas, Lichter, Peter

“…We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly…”
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Integrative genomic and transcriptomic analysis of leiomyosarcoma by Chudasama, Priya, Mughal, Sadaf S., Sanders, Mathijs A., Hübschmann, Daniel, Chung, Inn, Deeg, Katharina I., Wong, Siao-Han, Rabe, Sophie, Hlevnjak, Mario, Zapatka, Marc, Ernst, Aurélie, Kleinheinz, Kortine, Schlesner, Matthias, Sieverling, Lina, Klink, Barbara, Schröck, Evelin, Hoogenboezem, Remco M., Kasper, Bernd, Heilig, Christoph E., Egerer, Gerlinde, Wolf, Stephan, von Kalle, Christof, Eils, Roland, Stenzinger, Albrecht, Weichert, Wilko, Glimm, Hanno, Gröschel, Stefan, Kopp, Hans-Georg, Omlor, Georg, Lehner, Burkhard, Bauer, Sebastian, Schimmack, Simon, Ulrich, Alexis, Mechtersheimer, Gunhild, Rippe, Karsten, Brors, Benedikt, Hutter, Barbara, Renner, Marcus, Hohenberger, Peter, Scholl, Claudia, Fröhling, Stefan

“…Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically…”
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Precision oncology based on omics data: The NCT Heidelberg experience by Horak, Peter, Klink, Barbara, Heining, Christoph, Gröschel, Stefan, Hutter, Barbara, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Schlesner, Matthias, Eils, Roland, Richter, Daniela, Pfütze, Katrin, Geörg, Christina, Meißburger, Bettina, Wolf, Stephan, Schulz, Angela, Penzel, Roland, Herpel, Esther, Kirchner, Martina, Lier, Amelie, Endris, Volker, Singer, Stephan, Schirmacher, Peter, Weichert, Wilko, Stenzinger, Albrecht, Schlenk, Richard F., Schröck, Evelin, Brors, Benedikt, von Kalle, Christof, Glimm, Hanno, Fröhling, Stefan

“…Precision oncology implies the ability to predict which patients will likely respond to specific cancer therapies based on increasingly accurate,…”
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The landscape of chromothripsis across adult cancer types by Voronina, Natalia, Wong, John K. L., Hübschmann, Daniel, Hlevnjak, Mario, Uhrig, Sebastian, Heilig, Christoph E., Horak, Peter, Kreutzfeldt, Simon, Mock, Andreas, Stenzinger, Albrecht, Hutter, Barbara, Fröhlich, Martina, Brors, Benedikt, Jahn, Arne, Klink, Barbara, Gieldon, Laura, Sieverling, Lina, Feuerbach, Lars, Chudasama, Priya, Beck, Katja, Kroiss, Matthias, Heining, Christoph, Möhrmann, Lino, Fischer, Andrea, Schröck, Evelin, Glimm, Hanno, Zapatka, Marc, Lichter, Peter, Fröhling, Stefan, Ernst, Aurélie

“…Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of…”
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Genetic Interactions and Tissue Specificity Modulate the Association of Mutations with Drug Response by Cramer, Dina, Mazur, Johanna, Espinosa, Octavio, Schlesner, Matthias, Hübschmann, Daniel, Eils, Roland, Staub, Eike

“…In oncology, biomarkers are widely used to predict subgroups of patients that respond to a given drug. Although clinical decisions often rely on single gene…”
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Mutational patterns and regulatory networks in epigenetic subgroups of meningioma by Paramasivam, Nagarajan, Hübschmann, Daniel, Toprak, Umut H, Ishaque, Naveed, Neidert, Marian, Schrimpf, Daniel, Stichel, Damian, Reuss, David, Sievers, Philipp, Reinhardt, Annekathrin, Wefers, Annika K., Jones, David T. W., Gu, Zuguang, Werner, Johannes, Uhrig, Sebastian, Wirsching, Hans-Georg, Schick, Matthias, Bewerunge-Hudler, Melanie, Beck, Katja, Brehmer, Stephanie, Urbschat, Steffi, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Herold-Mende, Christel, Ketter, Ralf, Eils, Roland, Ram, Zvi, Pfister, Stefan M., Wick, Wolfgang, Weller, Michael, Grossmann, Rachel, von Deimling, Andreas, Schlesner, Matthias, Sahm, Felix

“…DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign…”
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Defective homologous recombination DNA repair as therapeutic target in advanced chordoma by Gröschel, Stefan, Hübschmann, Daniel, Raimondi, Francesco, Horak, Peter, Warsow, Gregor, Fröhlich, Martina, Klink, Barbara, Gieldon, Laura, Hutter, Barbara, Kleinheinz, Kortine, Bonekamp, David, Marschal, Oliver, Chudasama, Priya, Mika, Jagoda, Groth, Marie, Uhrig, Sebastian, Krämer, Stephen, Heining, Christoph, Heilig, Christoph E., Richter, Daniela, Reisinger, Eva, Pfütze, Katrin, Eils, Roland, Wolf, Stephan, von Kalle, Christof, Brandts, Christian, Scholl, Claudia, Weichert, Wilko, Richter, Stephan, Bauer, Sebastian, Penzel, Roland, Schröck, Evelin, Stenzinger, Albrecht, Schlenk, Richard F., Brors, Benedikt, Russell, Robert B., Glimm, Hanno, Schlesner, Matthias, Fröhling, Stefan

“…Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that…”
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Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity by Möhrmann, Lino, Werner, Maximilian, Oleś, Małgorzata, Mock, Andreas, Uhrig, Sebastian, Jahn, Arne, Kreutzfeldt, Simon, Fröhlich, Martina, Hutter, Barbara, Paramasivam, Nagarajan, Richter, Daniela, Beck, Katja, Winter, Ulrike, Pfütze, Katrin, Heilig, Christoph E., Teleanu, Veronica, Lipka, Daniel B., Zapatka, Marc, Hanf, Dorothea, List, Catrin, Allgäuer, Michael, Penzel, Roland, Rüter, Gina, Jelas, Ivan, Hamacher, Rainer, Falkenhorst, Johanna, Wagner, Sebastian, Brandts, Christian H., Boerries, Melanie, Illert, Anna L., Metzeler, Klaus H., Westphalen, C. Benedikt, Desuki, Alexander, Kindler, Thomas, Folprecht, Gunnar, Weichert, Wilko, Brors, Benedikt, Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Horak, Peter, Heining, Christoph, Fröhling, Stefan, Glimm, Hanno

“…The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is unclear. Here, we use comprehensive molecular characterization by whole…”
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Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops by Sakhtemani, Ramin, Perera, Madusha L W, Hübschmann, Daniel, Siebert, Reiner, Lawrence, Michael S, Bhagwat, Ashok S

“…Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch…”
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Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management by Lenschow, Christina, Fuss, Carmina Teresa, Kircher, Stefan, Buck, Andreas, Kickuth, Ralph, Reibetanz, Joachim, Wiegering, Armin, Stenzinger, Albrecht, Hübschmann, Daniel, Germer, Christoph Thomas, Fassnacht, Martin, Fröhling, Stefan, Schlegel, Nicolas, Kroiss, Matthias

“…Parathyroid carcinoma (PC) is an orphan malignancy accounting for only ~1% of all cases with primary hyperparathyroidism. The localization of recurrent PC is…”
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Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines by Kuseyri Hübschmann, Oya, Horvath, Gabriella, Cortès-Saladelafont, Elisenda, Yıldız, Yılmaz, Mastrangelo, Mario, Pons, Roser, Friedman, Jennifer, Mercimek-Andrews, Saadet, Wong, Suet-Na, Pearson, Toni S., Zafeiriou, Dimitrios I., Kulhánek, Jan, Kurian, Manju A., López-Laso, Eduardo, Oppebøen, Mari, Kılavuz, Sebile, Wassenberg, Tessa, Goez, Helly, Scholl-Bürgi, Sabine, Porta, Francesco, Honzík, Tomáš, Santer, René, Burlina, Alberto, Sivri, H. Serap, Leuzzi, Vincenzo, Hoffmann, Georg F., Jeltsch, Kathrin, Hübschmann, Daniel, Garbade, Sven F., García-Cazorla, Angeles, Opladen, Thomas

“…Inherited disorders of neurotransmitter metabolism are rare neurodevelopmental diseases presenting with movement disorders and global developmental delay. This…”
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An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids by Deininger, Luca, Jung-Klawitter, Sabine, Mikut, Ralf, Richter, Petra, Fischer, Manuel, Karimian-Jazi, Kianush, Breckwoldt, Michael O., Bendszus, Martin, Heiland, Sabine, Kleesiek, Jens, Opladen, Thomas, Kuseyri Hübschmann, Oya, Hübschmann, Daniel, Schwarz, Daniel

“…Cerebral organoids recapitulate the structure and function of the developing human brain in vitro , offering a large potential for personalized therapeutic…”
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Fibroblast Activation Protein α-Directed Imaging and Therapy of Solitary Fibrous Tumor by Hamacher, Rainer, Pabst, Kim M, Cheung, Phyllis F, Heilig, Christoph E, Hüllein, Jennifer, Liffers, Sven-Thorsten, Borchert, Sabrina, Costa, Pedro Fragoso, Schaarschmidt, Benedikt M, Kessler, Lukas, Miera, Monika A, Droste, Margret, Akbulut, Merve, Falkenhorst, Johanna, Zarrad, Fadi, Kostbade, Karina, Mavroeidi, Ilektra A, Glimm, Hanno, Umutlu, Lale, Schuler, Martin, Hübschmann, Daniel, Bauer, Sebastian, Fröhling, Stefan, Herrmann, Ken, Siveke, Jens T, Schildhaus, Hans-Ulrich, Fendler, Wolfgang P

“…Fibroblast activation protein α (FAPα) is expressed at high levels in several types of tumors. Here, we report the expression pattern of FAPα in solitary…”
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Gene expression-based prediction of pazopanib efficacy in sarcoma by Heilig, Christoph E., Laßmann, Andreas, Mughal, Sadaf S., Mock, Andreas, Pirmann, Sebastian, Teleanu, Veronica, Renner, Marcus, Andresen, Carolin, Köhler, Bruno C., Aybey, Bogac, Bauer, Sebastian, Siveke, Jens T., Hamacher, Rainer, Folprecht, Gunnar, Richter, Stephan, Schröck, Evelin, Brandts, Christian H., Ahrens, Marit, Hohenberger, Peter, Egerer, Gerlinde, Kindler, Thomas, Boerries, Melanie, Illert, Anna L., von Bubnoff, Nikolas, Apostolidis, Leonidas, Jost, Philipp J., Westphalen, C. Benedikt, Weichert, Wilko, Keilholz, Ulrich, Klauschen, Frederick, Beck, Katja, Winter, Ulrike, Richter, Daniela, Möhrmann, Lino, Bitzer, Michael, Schulze-Osthoff, Klaus, Brors, Benedikt, Mechtersheimer, Gunhild, Kreutzfeldt, Simon, Heining, Christoph, Lipka, Daniel B., Stenzinger, Albrecht, Schlenk, Richard F., Horak, Peter, Glimm, Hanno, Hübschmann, Daniel, Fröhling, Stefan

“…The multi-receptor tyrosine kinase inhibitor pazopanib is approved for the treatment of advanced soft-tissue sarcoma and has also shown activity in other…”
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Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions by Schöpf, Julia, Uhrig, Sebastian, Heilig, Christoph E., Lee, Kwang-Seok, Walther, Tatjana, Carazzato, Alexander, Dobberkau, Anna Maria, Weichenhan, Dieter, Plass, Christoph, Hartmann, Mark, Diwan, Gaurav D., Carrero, Zunamys I., Ball, Claudia R., Hohl, Tobias, Kindler, Thomas, Rudolph-Hähnel, Patricia, Helm, Dominic, Schneider, Martin, Nilsson, Anna, Øra, Ingrid, Imle, Roland, Banito, Ana, Russell, Robert B., Jones, Barbara C., Lipka, Daniel B., Glimm, Hanno, Hübschmann, Daniel, Hartmann, Wolfgang, Fröhling, Stefan, Scholl, Claudia

“…Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate…”
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Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity by Hoefflin, Rouven, Lahrmann, Bernd, Warsow, Gregor, Hübschmann, Daniel, Spath, Cathleen, Walter, Britta, Chen, Xin, Hofer, Luisa, Macher-Goeppinger, Stephan, Tolstov, Yanis, Korzeniewski, Nina, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Perner, Sven, Schönberg, Gita, Nyarangi-Dix, Joanne, Isaac, Sanjay, Hatiboglu, Gencay, Teber, Dogu, Hadaschik, Boris, Pahernik, Sascha, Roth, Wilfried, Eils, Roland, Schlesner, Matthias, Sültmann, Holger, Hohenfellner, Markus, Grabe, Niels, Duensing, Stefan

“…Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell…”
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Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling by Teleanu, Maria‐Veronica, Fuss, Carmina T., Paramasivam, Nagarajan, Pirmann, Sebastian, Mock, Andreas, Terkamp, Christoph, Kircher, Stefan, Landwehr, Laura‐Sophie, Lenschow, Christina, Schlegel, Nicolas, Stenzinger, Albrecht, Jahn, Arne, Fassnacht, Martin, Glimm, Hanno, Hübschmann, Daniel, Fröhling, Stefan, Kroiss, Matthias

“…Parathyroid carcinoma (PC) is an ultra‐rare malignancy with a high risk of recurrence after surgery. Tumour‐directed systemic treatments for PC are not…”
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