Search Results - "Hörnquist, E"

Altered faecal and mucosal microbial composition in post‐infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress by Sundin, J., Rangel, I., Fuentes, S., Heikamp‐de Jong, I., Hultgren‐Hörnquist, E., Vos, W. M., Brummer, R. J.

“…Summary Background A subset of irritable bowel syndrome (IBS) patients, denoted post‐infectious IBS (PI‐IBS), develop symptoms after an enteric infection…”
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Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients by Elgbratt, K, Kurlberg, G, Hahn-Zohric, M, Hörnquist, E. Hultgren

“…Inflammatory bowel disease (IBD) is associated with imbalances of the local intestinal immune responses, with dysregulated CD4⁺ T cells contributing to the…”
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Pathogenesis of Microscopic Colitis: A Systematic Review by Zabana, Yamile, Tontini, Gian, Hultgren-Hörnquist, Elisabeth, Skonieczna-Żydecka, Karolina, Latella, Giovanni, Østvik, Ann Elisabeth, Marlicz, Wojciech, D’Amato, Mauro, Arias, Angel, Miehlke, Stephan, Münch, Andreas, Fernández-Bañares, Fernando, Lucendo, Alfredo J

“…Abstract Background Whereas the exact aetiology of microscopic colitis [MC] remains unknown, a dysregulated immune response to luminal factors or medications…”
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PP112-SUN ALTERED COMPOSITION OF LYMPHOCYTES IN THE INTESTINAL MUCOSA OF PI-IBS PATIENTS by Sundin, J, Kumawat, A, Hultgren-Hörnquist, E, Rangel, I, König, J, Brummer, R.J

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Dextran Sulfate Sodium-induced Colitis Generates a Transient Thymic Involution - Impact on Thymocyte Subsets by Fritsch Fredin, M, Elgbratt, K, Svensson, D, Jansson, L, Melgar, S, Hultgren Hörnquist, E

“…One of the most widely used animal models for inflammatory bowel disease (IBD) is the dextran sulfate sodium (DSS)-induced colitis. We have previously reported…”
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Regression of Peyer's patches in Gαi2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis by Öhman, L, Franzén, L, Rudolph, U, Birnbaumer, L, Hörnquist, E Hultgren

“…Background: G protein deficient (Gαi2−/−) mice spontaneously develop an inflammatory bowel disease (IBD) closely resembling ulcerative colitis. Previous…”
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Toll‐like Receptor Cross‐hyporesponsiveness is Functional in Interleukin‐1‐receptor‐associated Kinase‐1 (IRAK‐1)‐deficient Macrophages: Differential Role Played by IRAK‐1 in Regulation of Tumour Necrosis Factor and Interleukin‐10 Production by Berglund, M., Thomas, J. A., Hörnquist, E. H., Hultgren, O. H.

“…Signalling downstream Toll‐like receptors (TLR) is regulated at several levels in order to activate the immune response and prevent excessive inflammation…”
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Acellular Bordetella pertussis vaccine enhances mucosal interleukin‐10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Gαi2‐deficient mice by Öhman, L., Willén, R., Hultgren, O. H., Hultgren Hörnquist, E.

“…Summary Mice deficient for the inhibitory G protein subunit α2 (Gαi2–/–) spontaneously develop a progressive inflammatory bowel disease resembling ulcerative…”
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LB030-MON INCREASED NUMBER OF DOUBLE POSITIVE CD3+ CD8+ CD4+ LAMINA PROPRIA T LYMPHOCYTES IN THE GUT MUCOSA OF POST INFECTIOUS IBS PATIENTS COMPARED TO HEALTHY CONTROLS by Sundín, J, Rangel, I, Hultgren-Hörnquist, E, Brummer, R

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Decreased leptin production in mice after onset of ulcerative colitis-like disease by Hultgren, O. H., Öhman, L., Hörnquist, E. Hultgren

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Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice by Ohman, L, Willén, R, Hultgren, O H, Hultgren Hörnquist, E

“…Mice deficient for the inhibitory G protein subunit alpha2 (Galphai2(-/-)) spontaneously develop a progressive inflammatory bowel disease resembling ulcerative…”
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CD8‐deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin by HÖRNQUIST, E., GRDÌC, D., MAK, T., LYCKE, N.

“…We used normal, CD4 and CD8 gene‐targeted mice to investigate the role of CD4+ and CD8+ T cells in the regulation of gut mucosal immune responses following…”
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Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin- specific protective immunity despite normal gut mucosal IgA differentiation by Hornquist, CE, Ekman, L, Grdic, KD, Schon, K, Lycke, NY

“…Using normal and CD4 gene-targeted (CD4-/-) mice, we asked whether mucosal immune responses and IgA B cell differentiation require the presence of CD4+ T…”
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Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin by Mielcarek, Nathalie, Hörnquist, Elisabeth Hultgren, Johansson, Bengt R., Locht, Camille, Abraham, Soman N., Holmgren, Jan

“…Together with macrophages and dendritic cells, mast cells have recently been shown to interact with certain pathogenic bacteria and present microbial antigens…”
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Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Gαi2-deficient mice by Hultgren, OH

“…AIM： To study the serum concentration of IL-1β, IL-1 receptor antagonist （IL-1Ra） and IL-18 in Gαi2-deficient mice at the age of 6 （healthy）, 12 （pre-colitic）…”
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Diagnosis and management of microscopic colitis: current perspectives by Bohr, Johan, Wickbom, Anna, Hegedus, Agnes, Nyhlin, Nils, Hultgren Hörnquist, Elisabeth, Tysk, Curt

“…Collagenous colitis and lymphocytic colitis, together constituting microscopic colitis, are common causes of chronic diarrhea. They are characterized…”
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Cholera toxin adjuvant greatly promotes antigen priming of T cells by Hörnquist, E, Lycke, N

“…Cholera toxin (CT) given perorally is a powerful mucosal immunogen and adjuvant. Information that explains the adjuvant effect of CT may be used for the…”
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Antibody response to dietary and autoantigens in Gαi2-deficient mice by Uhlig, Holm H, Hultgren Hörnquist, Elisabeth, Bache, Lena Öhman, Rudolph, Uwe, Birnbaumer, Lutz, Mothes, Thomas

“…BACKGROUND Mice with a targeted mutation in the G protein subunit Gαi2 gene develop a colonic mucosal inflammation, with a highly activated B-cell response. We…”
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Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa by Grdic, Dubravka, Hornquist, Elisabeth, Kjerrulf, Martin, Lycke, Nils Y

“…We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8-/-) mice induced oral tolerance that was comparable in both magnitude and quality…”
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The mucosal adjuvant effects of cholera toxin and immune‐stimulating complexes differ in their requirement for IL‐12, indicating different pathways of action by Grdic, Dubravka, Smith, Rosemary, Donachie, Anne, Kjerrulf, Martin, Hörnquist, Elisabeth, Mowat, Allan, Lycke, Nils

“…Adjuvants that can improve mucosal vaccine efficacy are much warranted. In this comparative study between cholera toxin (CT) and immune‐stimulating complexes…”
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