Search Results - "Höpken, Uta"

Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth by Menzel, Lutz, Höpken, Uta E, Rehm, Armin

“…Tumor-induced remodeling of the microenvironment in lymph nodes (LNs) includes the formation of blood vessels, which goes beyond the regulation of metabolism,…”
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CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury by Lodka, Dörte, Zschummel, Maria, Bunse, Mario, Rousselle, Anthony, Sonnemann, Janis, Kettritz, Ralph, Höpken, Uta E, Schreiber, Adrian

“…Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as…”
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A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation by Vallecillo-García, Pedro, Orgeur, Mickael, Comai, Glenda, Poehle-Kronawitter, Sophie, Fischer, Cornelius, Gloger, Marleen, Dumas, Camille E., Giesecke-Thiel, Claudia, Sauer, Sascha, Tajbakhsh, Shahragim, Höpken, Uta E., Stricker, Sigmar

“…During development, lymph node (LN) initiation is coordinated by lymphoid tissue organizer (LTo) cells that attract lymphoid tissue inducer (LTi) cells at…”
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B‐cell‐intrinsic STAT6 signaling controls germinal center formation by Turqueti‐Neves, Adriana, Otte, Manuel, Costa, Olivia Prazeres, Höpken, Uta E., Lipp, Martin, Buch, Thorsten, Voehringer, David

“…Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL‐4 and IL‐13 by CD4+ T…”
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The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 by Stauss, Dennis, Brunner, Cornelia, Berberich-Siebelt, Friederike, Höpken, Uta E, Lipp, Martin, Müller, Gerd

“…Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long‐term humoral immunity. Tfh cell differentiation requires the…”
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Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence by Kolesnichenko, Marina, Mikuda, Nadine, Höpken, Uta E, Kärgel, Eva, Uyar, Bora, Tufan, Ahmet Bugra, Milanovic, Maja, Sun, Wei, Krahn, Inge, Schleich, Kolja, von Hoff, Linda, Hinz, Michael, Willenbrock, Michael, Jungmann, Sabine, Akalin, Altuna, Lee, Soyoung, Schmidt‐Ullrich, Ruth, Schmitt, Clemens A, Scheidereit, Claus

“…The IκB kinase (IKK)‐NF‐κB pathway is activated as part of the DNA damage response and controls both inflammation and resistance to apoptosis. How these…”
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CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells by Bunse, Mario, Pfeilschifter, Janina, Bluhm, Julia, Zschummel, Maria, Joedicke, Jara J., Wirges, Anthea, Stark, Helen, Kretschmer, Vivien, Chmielewski, Markus, Uckert, Wolfgang, Abken, Hinrich, Westermann, Jörg, Rehm, Armin, Höpken, Uta E.

“…CAR-T cell therapy targeting CD19 demonstrated strong activity against advanced B cell leukemia, however shows less efficacy against lymphoma with nodal…”
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The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions by Scholz, Florian, Grau, Michael, Menzel, Lutz, Graband, Annika, Zapukhlyak, Myroslav, Leutz, Achim, Janz, Martin, Lenz, Georg, Rehm, Armin, Höpken, Uta E.

“…Dendritic cell (DC) maturation is a prerequisite for the induction of adaptive immune responses against pathogens and cancer. Transcription factor (TF)…”
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Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways by Gloger, Marleen, Menzel, Lutz, Grau, Michael, Vion, Anne-Clemence, Anagnostopoulos, Ioannis, Zapukhlyak, Myroslav, Gerlach, Kerstin, Kammertöns, Thomas, Hehlgans, Thomas, Zschummel, Maria, Lenz, Georg, Gerhardt, Holger, Höpken, Uta E, Rehm, Armin

“…Tumor-induced remodeling of the microenvironment relies on the formation of blood vessels, which go beyond the regulation of metabolism, shaping a maladapted…”
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Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma by Cichocki, Frank, Bjordahl, Ryan, Goodridge, Jodie P., Mahmood, Sajid, Gaidarova, Svetlana, Abujarour, Ramzey, Davis, Zachary B., Merino, Aimee, Tuininga, Katie, Wang, Hongbo, Kumar, Akhilesh, Groff, Brian, Witty, Alec, Bonello, Greg, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Malmberg, Karl-Johan, Walcheck, Bruce, Höpken, Uta, Rehm, Armin, Valamehr, Bahram, Miller, Jeffrey S.

“…Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of multiple myeloma…”
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The Sorting Receptor Sortilin Exhibits a Dual Function in Exocytic Trafficking of Interferon-γ and Granzyme A in T Cells by Herda, Stefanie, Raczkowski, Friederike, Mittrücker, Hans-Willi, Willimsky, Gerald, Gerlach, Kerstin, Kühl, Anja A., Breiderhoff, Tilman, Willnow, Thomas E., Dörken, Bernd, Höpken, Uta E., Rehm, Armin

“…Immunological control of infections or tumors depends on the release of effector cytokines and polarized secretion of cytotoxic granules from T cells and…”
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CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin’s Lymphoma and Multiple Myeloma by Bluhm, Julia, Kieback, Elisa, Marino, Stephen F., Oden, Felix, Westermann, Jörg, Chmielewski, Markus, Abken, Hinrich, Uckert, Wolfgang, Höpken, Uta E., Rehm, Armin

“…Autologous T cells genetically modified with a chimeric antigen receptor (CAR) redirected at CD19 have potent activity in the treatment of B cell leukemia and…”
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Distinctive role of CCR7 in migration and functional activity of naive‐ and effector/memory‐like Treg subsets by Menning, Astrid, Höpken, Uta E., Siegmund, Kerstin, Lipp, Martin, Hamann, Alf, Huehn, Jochen

“…Foxp3+CD25+CD4+ Treg play a fundamental role in the maintenance of self tolerance and the control of inflammatory reactions. Previous data demonstrated a…”
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Lymphocyte access to lymphoma is impaired by high endothelial venule regression by Menzel, Lutz, Zschummel, Maria, Crowley, Tadhg, Franke, Vedran, Grau, Michael, Ulbricht, Carolin, Hauser, Anja, Siffrin, Volker, Bajénoff, Marc, Acton, Sophie E., Akalin, Altuna, Lenz, Georg, Willimsky, Gerald, Höpken, Uta E., Rehm, Armin

“…Blood endothelial cells display remarkable plasticity depending on the demands of a malignant microenvironment. While studies in solid tumors focus on their…”
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Targeting HDAC3 in CREBBP-Mutant Lymphomas Counterstrikes Unopposed Enhancer Deacetylation of B-cell Signaling and Immune Response Genes by Höpken, Uta E

“…The cellular phenotype of B-cell lymphomas arising from B cells undergoing germinal center reactions, such as follicular lymphoma and diffuse large B-cell…”
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EBAG9 silencing exerts an immune checkpoint function without aggravating adverse effects by Wirges, Anthea, Bunse, Mario, Joedicke, Jara J., Blanc, Eric, Gudipati, Venugopal, Moles, Michael W., Shiku, Hiroshi, Beule, Dieter, Huppa, Johannes B., Höpken, Uta E., Rehm, Armin

“…Chimeric antigen receptor (CAR) T cells have revolutionized treatment of B cell malignancies. However, enhancing the efficacy of engineered T cells without…”
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In Vitro Functionality and Endurance of GMP-Compliant Point-of-Care BCMA.CAR-T Cells at Different Timepoints of Cryopreservation by Jiang, Genqiao, Neuber, Brigitte, Hückelhoven-Krauss, Angela, Höpken, Uta E, Ding, Yuntian, Sedloev, David, Wang, Lei, Reichman, Avinoam, Eberhardt, Franziska, Wermke, Martin, Rehm, Armin, Müller-Tidow, Carsten, Schmitt, Anita, Schmitt, Michael

“…The search for target antigens for CAR-T cell therapy against multiple myeloma defined the B-cell maturation antigen (BCMA) as an interesting candidate…”
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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation by Mebius, Reina E, van de Pavert, Serge A, Olivier, Brenda J, Goverse, Gera, Vondenhoff, Mark F, Greuter, Mascha, Beke, Patrick, Kusser, Kim, Höpken, Uta E, Lipp, Martin, Niederreither, Karen, Blomhoff, Rune, Sitnik, Kasia, Agace, William W, Randall, Troy D, de Jonge, Wouter J

“…Embryonic lymph node formation requires lymphoid tissue–inducer cells. Mebius and colleagues show that neurons adjacent to lymph anlagen synthesize retinoic…”
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Accelerating clinical-scale production of BCMA CAR T cells with defined maturation stages by Joedicke, Jara J., Großkinsky, Ulrich, Gerlach, Kerstin, Künkele, Annette, Höpken, Uta E., Rehm, Armin

“…The advent of CAR T cells targeting CD19 or BCMA on B cell neoplasm demonstrated remarkable efficacy, but rapid relapses and primary refractoriness remains…”
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Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut by Mikuda, Nadine, Schmidt‐Ullrich, Ruth, Kärgel, Eva, Golusda, Laura, Wolf, Jana, Höpken, Uta E, Scheidereit, Claus, Kühl, Anja A, Kolesnichenko, Marina

“…The IκB kinase (IKK)–NF‐κB signaling pathway plays a multifaceted role in inflammatory bowel disease (IBD): on the one hand, it protects from apoptosis; on the…”
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