Search Results - "Höglund, Kina"

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology by Portelius, Erik, Olsson, Bob, Höglund, Kina, Cullen, Nicholas C., Kvartsberg, Hlin, Andreasson, Ulf, Zetterberg, Henrik, Sandelius, Åsa, Shaw, Leslie M., Lee, Virginia M. Y., Irwin, David J., Grossman, Murray, Weintraub, Daniel, Chen-Plotkin, Alice, Wolk, David A., McCluskey, Leo, Elman, Lauren, McBride, Jennifer, Toledo, Jon B., Trojanowski, John Q., Blennow, Kaj

“…Neurogranin (Ng) is a post-synaptic protein that previously has been shown to be a biomarker for synaptic function when measured in cerebrospinal fluid (CSF)…”
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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders by Ashton, Nicholas J., Hye, Abdul, Rajkumar, Anto P., Leuzy, Antoine, Snowden, Stuart, Suárez-Calvet, Marc, Karikari, Thomas K., Schöll, Michael, La Joie, Renaud, Rabinovici, Gil D., Höglund, Kina, Ballard, Clive, Hortobágyi, Tibor, Svenningsson, Per, Blennow, Kaj, Zetterberg, Henrik, Aarsland, Dag

“…Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not…”
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Extensive Plasmid Library to Prepare Tau Protein Variants and Study Their Functional Biochemistry by Karikari, Thomas K, Keeling, Sophie, Hill, Emily, Lantero Rodrı́guez, Juan, Nagel, David A, Becker, Bruno, Höglund, Kina, Zetterberg, Henrik, Blennow, Kaj, Hill, Eric J, Moffat, Kevin G

“…Tau neurofibrillary tangles are key pathological features of Alzheimer’s disease and other tauopathies. Recombinant protein technology is vital for studying…”
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Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics by Behzadi, Arvin, Pujol-Calderón, Fani, Tjust, Anton E., Wuolikainen, Anna, Höglund, Kina, Forsberg, Karin, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Andersen, Peter Munch

“…Delayed diagnosis and misdiagnosis are frequent in people with amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease (MND)…”
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Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease by Tible, Marion, Sandelius, Åsa, Höglund, Kina, Brinkmalm, Ann, Cognat, Emmanuel, Dumurgier, Julien, Zetterberg, Henrik, Hugon, Jacques, Paquet, Claire, Blennow, Kaj

“…OBJECTIVETo assess the ability of a combination of synaptic CSF biomarkers to separate Alzheimer disease (AD) and non-AD disorders and to help in the…”
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Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke by Pujol-Calderón, Fani, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Rosengren, Lars E., Höglund, Kina

“…•Neurofilament concentrations reflect neuronal injury after acute ischemic stroke.•The highest concentration of neurofilaments appears 3 weeks after ischaemic…”
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A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation by Gaetani, Lorenzo, Höglund, Kina, Parnetti, Lucilla, Pujol-Calderon, Fani, Becker, Bruno, Eusebi, Paolo, Sarchielli, Paola, Calabresi, Paolo, Di Filippo, Massimiliano, Zetterberg, Henrik, Blennow, Kaj

“…Cerebrospinal fluid (CSF) neurofilament light (NfL) is a reliable marker of neuro-axonal damage in different neurological disorders that is related to disease…”
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Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders by Olsson, Bob, Portelius, Erik, Cullen, Nicholas C, Sandelius, Åsa, Zetterberg, Henrik, Andreasson, Ulf, Höglund, Kina, Irwin, David J, Grossman, Murray, Weintraub, Daniel, Chen-Plotkin, Alice, Wolk, David, McCluskey, Leo, Elman, Lauren, Shaw, Leslie M, Toledo, Jon B, McBride, Jennifer, Hernandez-Con, Pilar, Lee, Virginia M-Y, Trojanowski, John Q, Blennow, Kaj

“…Neuronal and axonal destruction are hallmarks of neurodegenerative diseases, but it is difficult to estimate the extent and progress of the damage in the…”
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Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia by Bereczki, Erika, Francis, Paul T, Howlett, David, Pereira, Joana B, Höglund, Kina, Bogstedt, Anna, Cedazo-Minguez, Angel, Baek, Jean-Ha, Hortobágyi, Tibor, Attems, Johannes, Ballard, Clive, Aarsland, Dag

“…Abstract Introduction Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A,…”
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Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration by Ashton, Nicholas J, Leuzy, Antoine, Lim, Yau Mun, Troakes, Claire, Hortobágyi, Tibor, Höglund, Kina, Aarsland, Dag, Lovestone, Simon, Schöll, Michael, Blennow, Kaj, Zetterberg, Henrik, Hye, Abdul

“…Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in…”
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Neurochemical Aftermath of Repetitive Mild Traumatic Brain Injury by Shahim, Pashtun, Tegner, Yelverton, Gustafsson, Bengt, Gren, Magnus, Ärlig, Johan, Olsson, Martin, Lehto, Niklas, Engström, Åsa, Höglund, Kina, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj

“…Evidence is accumulating that repeated mild traumatic brain injury (mTBI) incidents can lead to persistent, long-term debilitating symptoms and in some cases a…”
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Prevalence of preclinical Alzheimer disease: Comparison of current classification systems by Kern, Silke, Zetterberg, Henrik, Kern, Jürgen, Zettergren, Anna, Waern, Margda, Höglund, Kina, Andreasson, Ulf, Wetterberg, Hanna, Börjesson-Hanson, Anne, Blennow, Kaj, Skoog, Ingmar

“…OBJECTIVETo determine the prevalence of preclinical Alzheimer disease (AD) according to current classification systems by examining CSF from a representative…”
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Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease by Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina

“…Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of…”
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The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer’s disease by Kvartsberg, Hlin, Lashley, Tammaryn, Murray, Christina E., Brinkmalm, Gunnar, Cullen, Nicholas C., Höglund, Kina, Zetterberg, Henrik, Blennow, Kaj, Portelius, Erik

“…Synaptic degeneration and neuronal loss are early events in Alzheimer’s disease (AD), occurring long before symptom onset, thus making synaptic biomarkers…”
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Alzheimer's disease — Recent biomarker developments in relation to updated diagnostic criteria by Höglund, Kina, Fourier, Anthony, Perret-Liaudet, Armand, Zetterberg, Henrik, Blennow, Kaj, Portelius, Erik

“…Alzheimer's disease (AD) is the most common cause of dementia and is characterized by neuroaxonal and synaptic degeneration accompanied by intraneuronal…”
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Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology by Blennow, Kaj, Chen, Chun, Cicognola, Claudia, Wildsmith, Kristin R, Manser, Paul T, Bohorquez, Sandra M Sanabria, Zhang, Zhentao, Xie, Boer, Peng, Junmin, Hansson, Oskar, Kvartsberg, Hlin, Portelius, Erik, Zetterberg, Henrik, Lashley, Tammaryn, Brinkmalm, Gunnar, Kerchner, Geoffrey A, Weimer, Robby M, Ye, Keqiang, Höglund, Kina

“…To date, there is no validated fluid biomarker for tau pathology in Alzheimer's disease, with contradictory results from studies evaluating the correlation…”
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Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons by Nazir, Faisal Hayat, Becker, Bruno, Brinkmalm, Ann, Höglund, Kina, Sandelius, Åsa, Bergström, Petra, Satir, Tugce Munise, Öhrfelt, Annika, Blennow, Kaj, Agholme, Lotta, Zetterberg, Henrik

“…Synaptic function and neurotransmitter release are regulated by specific proteins. Cortical neuronal differentiation of human induced pluripotent stem cells…”
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Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration by Höglund, Kina, Schussler, Nathalie, Kvartsberg, Hlin, Smailovic, Una, Brinkmalm, Gunnar, Liman, Victor, Becker, Bruno, Zetterberg, Henrik, Cedazo-Minguez, Angel, Janelidze, Shorena, Lefevre, Isabel A., Eyquem, Stéphanie, Hansson, Oskar, Blennow, Kaj

“…Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked to cognitive symptoms that precede…”
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Acute symptomatic seizures and epilepsy after mechanical thrombectomy by Eriksson, Hanna, Löwhagen Hendén, Pia, Rentzos, Alexandros, Pujol-Calderón, Fani, Karlsson, Jan-Erik, Höglund, Kina, Blennow, Kaj, Zetterberg, Henrik, Rosengren, Lars, Zelano, Johan

“…The purpose of this study was to assess the incidence of acute symptomatic seizures and poststroke epilepsy (PSE) in a well-characterized cohort of patients…”
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Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia by Olsson, Bob, Hertze, Joakim, Lautner, Ronald, Zetterberg, Henrik, Nägga, Katarina, Höglund, Kina, Basun, Hans, Annas, Peter, Lannfelt, Lars, Andreasen, Niels, Minthon, Lennart, Blennow, Kaj, Hansson, Oskar

“…Microglia manage immunosurveillance and mediate inflammation, both suggested to be important in Alzheimer's disease (AD). The aim of this study was to…”
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