Search Results - "Höfner, Georg C."

Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity by Gryzło, Beata, Zaręba, Paula, Malawska, Katarzyna, Mazur, Gabriela, Rapacz, Anna, Ła̧tka, Kamil, Höfner, Georg C, Latacz, Gniewomir, Bajda, Marek, Sałat, Kinga, Wanner, Klaus T, Malawska, Barbara, Kulig, Katarzyna

“…Neuropathic pain resistance to pharmacotherapy has encouraged researchers to develop effective therapies for its treatment. γ-Aminobutyric acid (GABA)…”
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Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease by Zaręba, Paula, Łątka, Kamil, Mazur, Gabriela, Gryzło, Beata, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Skrzypczak-Wiercioch, Anna, Höfner, Georg C., Latacz, Gniewomir, Maj, Maciej, Espargaró, Alba, Sabaté, Raimon, Jóźwiak, Krzysztof, Wanner, Klaus T., Sałat, Kinga, Malawska, Barbara, Kulig, Katarzyna, Bajda, Marek

“…Alzheimer's disease (AD) is a global health problem in the medical sector that will increase over time. The limited treatment of AD leads to the search for a…”
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Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity by Zaręba, Paula, Sałat, Kinga, Höfner, Georg C., Łątka, Kamil, Bajda, Marek, Latacz, Gniewomir, Kotniewicz, Krzysztof, Rapacz, Anna, Podkowa, Adrian, Maj, Maciej, Jóźwiak, Krzysztof, Filipek, Barbara, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna

“…γ-Aminobutyric acid (GABA) neurotransmission has a significant impact on the proper functioning of the central nervous system. Numerous studies have indicated…”
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Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice by Zaręba, Paula, Gryzło, Beata, Malawska, Katarzyna, Sałat, Kinga, Höfner, Georg C., Nowaczyk, Alicja, Fijałkowski, Łukasz, Rapacz, Anna, Podkowa, Adrian, Furgała, Anna, Żmudzki, Paweł, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna

“…γ-Aminobutyric acid (GABA) uptake transporters are membrane transport proteins that are involved in the pathophysiology of a number of neurological disorders…”
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Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase by Cattaneo, Giulia, Ubiali, Daniela, Calleri, Enrica, Rabuffetti, Marco, Höfner, Georg C., Wanner, Klaus T., De Moraes, Marcela C., Martinelli, Leonardo K.B., Santos, Diógenes Santiago, Speranza, Giovanna, Massolini, Gabriella

“…Mycobacterium tuberculosis (Mtb) purine nucleoside phosphorylase (PNP, EC 2.4.2.1) has been identified as a target for the development of specific inhibitors…”
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Synthesis, biological evaluation and structure–activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides by Kowalczyk, Paula, Sałat, Kinga, Höfner, Georg C., Mucha, Marta, Rapacz, Anna, Podkowa, Adrian, Filipek, Barbara, Wanner, Klaus T., Kulig, Katarzyna

“…Six series of 2-substituted 4-aminobutanamide derivatives were synthesized and evaluated for their ability to inhibit GABA transport proteins mGAT1−4 stably…”
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2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation by Kowalczyk, Paula, Sałat, Kinga, Höfner, Georg C., Guzior, Natalia, Filipek, Barbara, Wanner, Klaus T., Kulig, Katarzyna

“…A series of 2-substituted 4-hydroxybutanamide derivatives has been synthesized by the aminolysis of appropriate 2-substituted dihydrofuran-2(3H)-one…”
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Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors by Zhao, Xueqing, Pabel, Jörg, Höfner, Georg C., Wanner, Klaus T.

“…A series of enantiomerically pure 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives have been synthesized starting…”
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Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors by Kulig, Katarzyna, Więckowski, Krzysztof, Więckowska, Anna, Gajda, Justyna, Pochwat, Bartłomiej, Höfner, Georg C., Wanner, Klaus T., Malawska, Barbara

“…This study presents the synthesis of novel substituted 4-hydroxybutanamides and their influence on the activity of murine GABA transport proteins GAT1–GAT4…”
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Synthesis and pharmacological properties of new GABA uptake inhibitors by Sałat, Kinga, Więckowska, Anna, Więckowski, Krzysztof, Höfner, Georg C., Kamiński, Jacek, Wanner, Klaus T., Malawska, Barbara, Filipek, Barbara, Kulig, Katarzyna

“…γ-Aminobutanoic acid (GABA) is the principal inhibitory neurotransmitter in the mammalian central nervous system. The identification and subsequent development…”
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