Search Results - "Héroux, Annie"

Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase by Snyder, Phillip W, Mecinović, Jasmin, Moustakas, Demetri T, Thomas, Samuel W. III, Harder, Michael, Mack, Eric T, Lockett, Matthew R, Héroux, Annie, Sherman, Woody, Whitesides, George M

“…The hydrophobic effect—a rationalization of the insolubility of nonpolar molecules in water—is centrally important to biomolecular recognition. Despite…”
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The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6 by Van Oss, S. Branden, Shirra, Margaret K., Bataille, Alain R., Wier, Adam D., Yen, Kuangyu, Vinayachandran, Vinesh, Byeon, In-Ja L., Cucinotta, Christine E., Héroux, Annie, Jeon, Jongcheol, Kim, Jaehoon, VanDemark, Andrew P., Pugh, B. Franklin, Arndt, Karen M.

“…The five-subunit yeast Paf1 complex (Paf1C) regulates all stages of transcription and is critical for the monoubiquitylation of histone H2B (H2Bub), a…”
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Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 by Singh, Namit, Basnet, Harihar, Wiltshire, Timothy D, Mohammad, Duaa H, Thompson, James R, Héroux, Annie, Botuyan, Maria Victoria, Yaffe, Michael B, Couch, Fergus J, Rosenfeld, Michael G, Mer, Georges

“…Tyr142, the C-terminal amino acid of histone variant H2A.X is phosphorylated by WSTF (Williams-Beuren syndrome transcription factor), a component of the WICH…”
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Structural and functional studies on the interaction of GspC and GspD in the type II secretion system by Korotkov, Konstantin V, Johnson, Tanya L, Jobling, Michael G, Pruneda, Jonathan, Pardon, Els, Héroux, Annie, Turley, Stewart, Steyaert, Jan, Holmes, Randall K, Sandkvist, Maria, Hol, Wim G J

“…Type II secretion systems (T2SSs) are critical for secretion of many proteins from Gram-negative bacteria. In the T2SS, the outer membrane secretin GspD forms…”
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Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines by Roessler, Christian G., Kuczewski, Anthony, Stearns, Richard, Ellson, Richard, Olechno, Joseph, Orville, Allen M., Allaire, Marc, Soares, Alexei S., Héroux, Annie

“…To take full advantage of advanced data collection techniques and high beam flux at next‐generation macromolecular crystallography beamlines, rapid and…”
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Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain by Gelinas, Amy D, Paschini, Margherita, Reyes, Francis E, Héroux, Annie, Batey, Robert T, Lundblad, Victoria, Wuttke, Deborah S

“…Telomeres must be capped to preserve chromosomal stability. The conserved Stn1 and Ten1 proteins are required for proper capping of the telomere, although the…”
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Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target by Mulepati, Sabin, Héroux, Annie, Bailey, Scott

“…In prokaryotes, RNA derived from type I and type III CRISPR loci direct large ribonucleoprotein complexes to destroy invading bacteriophage and plasmids. In…”
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Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase by Mecinović, Jasmin, Snyder, Phillip W, Mirica, Katherine A, Bai, Serena, Mack, Eric T, Kwant, Richard L, Moustakas, Demetri T, Héroux, Annie, Whitesides, George M

“…The hydrophobic effect, the free-energetically favorable association of nonpolar solutes in water, makes a dominant contribution to binding of many systems of…”
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Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen by Gopalan, G, He, Z, Balmer, Y, Romano, P, Gupta, R, Heroux, A, Buchanan, B.B, Swaminathan, K, Luan, S

“…Change in redox status has long been known to link light to the posttranslational regulation of chloroplast enzymes. So far, studies have been conducted…”
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Correlated single-crystal electronic absorption spectroscopy and X-ray crystallography at NSLS beamline X26-C by Orville, Allen M., Buono, Richard, Cowan, Matt, Héroux, Annie, Shea-McCarthy, Grace, Schneider, Dieter K., Skinner, John M., Skinner, Michael J., Stoner-Ma, Deborah, Sweet, Robert M.

“…The research philosophy and new capabilities installed at NSLS beamline X26‐C to support electronic absorption and Raman spectroscopies coupled with X‐ray…”
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Transmission-mode diamond white-beam position monitor at NSLS by Muller, Erik M., Smedley, John, Bohon, Jen, Yang, Xi, Gaowei, Mengjia, Skinner, John, De Geronimo, Gianluigi, Sullivan, Michael, Allaire, Marc, Keister, Jeffrey W., Berman, Lonny, Héroux, Annie

“…Two transmission‐mode diamond X‐ray beam position monitors installed at National Synchrotron Light Source (NSLS) beamline X25 are described. Each diamond beam…”
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Interactions between Hofmeister Anions and the Binding Pocket of a Protein by Fox, Jerome M, Kang, Kyungtae, Sherman, Woody, Héroux, Annie, Sastry, G. Madhavi, Baghbanzadeh, Mostafa, Lockett, Matthew R, Whitesides, George M

“…This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to examine the properties of Hofmeister anions that determine…”
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Structure of Factor H-binding Protein B (FhbB) of the Periopathogen, Treponema denticola by Miller, Daniel P., Bell, Jessica K., McDowell, John V., Conrad, Daniel H., Burgner, John W., Héroux, Annie, Marconi, Richard T.

“…Periodontitis is the most common disease of microbial etiology in humans. Periopathogen survival is dependent upon evasion of complement-mediated destruction…”
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Water Networks Contribute to Enthalpy/Entropy Compensation in Protein–Ligand Binding by Breiten, Benjamin, Lockett, Matthew R, Sherman, Woody, Fujita, Shuji, Al-Sayah, Mohammad, Lange, Heiko, Bowers, Carleen M, Heroux, Annie, Krilov, Goran, Whitesides, George M

“…The mechanism (or mechanisms) of enthalpy–entropy (H/S) compensation in protein–ligand binding remains controversial, and there are still no predictive models…”
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Macromolecular crystallography beamline X25 at the NSLS by Héroux, Annie, Allaire, Marc, Buono, Richard, Cowan, Matthew L., Dvorak, Joseph, Flaks, Leon, LaMarra, Steven, Myers, Stuart F., Orville, Allen M., Robinson, Howard H., Roessler, Christian G., Schneider, Dieter K., Shea-McCarthy, Grace, Skinner, John M., Skinner, Michael, Soares, Alexei S., Sweet, Robert M., Berman, Lonny E.

“…Beamline X25 at the NSLS is one of the five beamlines dedicated to macromolecular crystallography operated by the Brookhaven National Laboratory Macromolecular…”
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First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer by Arturo, Emilia C., Gupta, Kushol, Héroux, Annie, Stith, Linda, Cross, Penelope J., Parker, Emily J., Loll, Patrick J., Jaffe, Eileen K.

“…Improved understanding of the relationship among structure, dynamics, and function for the enzyme phenylalanine hydroxylase (PAH) can lead to needed new…”
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Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin by Wier, Adam D., Mayekar, Manasi K., Héroux, Annie, Arndt, Karen M., VanDemark, Andrew P.

“…Polymerase associated factor 1 complex (Paf1C) broadly influences gene expression by regulating chromatin structure and the recruitment of RNA-processing…”
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The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence by Lahr, Roni M., Mack, Seshat M., Héroux, Annie, Blagden, Sarah P., Bousquet-Antonelli, Cécile, Deragon, Jean-Marc, Berman, Andrea J.

“…La-related protein 1 (LARP1) regulates the stability of many mRNAs. These include 5′TOPs, mTOR-kinase responsive mRNAs with pyrimidine-rich 5′ UTRs, which…”
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Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler by Schubert, Heidi L., Wittmeyer, Jacqueline, Kasten, Margaret M., Hinata, Kaede, Rawling, David C., Héroux, Annie, Cairns, Bradley R., Hill, Christopher P.

“…The packaging of DNA into nucleosomal structures limits access for templated processes such as transcription and DNA repair. The repositioning or ejection of…”
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Crystal Structure of the Lysine Riboswitch Regulatory mRNA Element by Garst, Andrew D., Héroux, Annie, Rambo, Robert P., Batey, Robert T.

“…Riboswitches are metabolite-sensitive elements found in mRNAs that control gene expression through a regulatory secondary structural switch. Along with…”
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