Search Results - "Héaulme, M"

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor by Rinaldi-Carmona, Murielle, Barth, Francis, Héaulme, Michel, Shire, David, Calandra, Bernard, Congy, Christian, Martinez, Serge, Maruani, Jeanne, Néliat, Gervais, Caput, Daniel, Ferrara, Pascual, Soubrié, Philippe, Brelière, Jean Claude, Le Fur, Gérard

“…SR141716A is the first selective and orally active antagonist of the brain cannabinoid receptor. This compound displays nanomolar affinity for the central…”
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Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist by Rinaldi-Carmona, M, Barth, F, Héaulme, M, Alonso, R, Shire, D, Congy, C, Soubrié, P, Brelière, J C, Le Fur, G

“…SR141716A is a selective, potent and orally active antagonist of the brain cannabinoid receptor with a long duration of action. This compound shows high…”
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Stimulation by neurotensin of ( 3H)5-hydroxytryptamine (5HT) release from rat frontal cortex slices by Héaulme, M, Leyris, R, Soubrié, P, Le Fur, G

“…The effect of neurotensin (NT) on the K +-evoked ( 3H)5HT release from brain frontal cortex slices was studied in rats. NT(1–13) and NT(8–13) increased (…”
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SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo by Bachy, A, Héaulme, M, Giudice, A, Michaud, J C, Lefevre, I A, Souilhac, J, Manara, L, Emerit, M B, Gozlan, H, Hamon, M

“…SR 57227A (4-amino-(6-chloro-2-pyridyl)-1 piperidine hydrochloride) is a novel compound with high affinity and selectivity for the 5-HT3 receptor. The compound…”
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Biochemical and Pharmacological Profile of a Potent and Selective Nonpeptide Antagonist of the Neurotensin Receptor by Gully, Danielle, Canton, Maryse, Boigegrain, Robert, Jeanjean, Francis, Molimard, Jean-Charles, Poncelet, Martine, Gueudet, Christiane, Heaulme, Michel, Leyris, Roger, Brouard, Aline, Pelaprat, Didier, Labbe-Jullie, Catherine, Mazella, Jean, Soubrie, Philippe, Maffrand, Jean-Pierre, Rostene, William, Kitabgi, Patrick, Le Fur, Gerard

“…We describe the characteristics of SR 48692, a selective, nonpeptide antagonist of the neurotensin receptor. In vitro, this compound competitively…”
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SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization by Bignon, E, Alonso, R, Arnone, M, Boigegrain, R, Brodin, R, Gueudet, C, Héaulme, M, Keane, P, Landi, M, Molimard, J C, Olliero, D, Poncelet, M, Seban, E, Simiand, J, Soubrié, P, Pascal, M, Maffrand, J P, Le Fur, G

“…SR146131 is a potent and selective agonist at cholecystokinin subtype 1 (CCK1) receptors in vitro. The present study evaluates the activity of the compound in…”
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Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells by Didier, M, Heaulme, M, Soubrié, P, Bockaert, J, Pin, J P

“…A simple and sensitive method adapted from the staining of living cells with fluorescein diacetate was developed to rapidly estimate the number of living cells…”
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Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-I SSR504734, a potential new type of antipsychotic by DEPOORTERE, Ronan, DARGAZANLI, Gihad, CUDENNEC, Annie, VOLTZ, Carolle, BOULAY, Denis, TERRANOVA, Jean Paul, STEMMELIN, Jeanne, ROGER, Pierre, MARABOUT, Benoit, SEVRIN, Mireille, VIGE, Xavier, BITON, Bruno, ESTENNE-BOUHTOU, Genevieve, STEINBERG, Régis, FRANCON, Dominique, ALONSO, Richard, AVENET, Patrick, OURY-DONAT, Florence, PERRAULT, Ghislaine, GRIEBEL, Guy, GEORGE, Pascal, SOUBRIE, Philippe, SCATTON, Bernard, COSTE, Annick, LANNEAU, Christophe, DESVIGNES, Christophe, PONCELET, Martine, HEAULME, Michel, SANTUCCI, Vincent, DECOBERT, Michel

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Neurobehavioural effects of SR 27897, a selective cholecystokinin type A (CCK-A) receptor antagonist by PONCELET, M, ARNONE, M, SOUBRIE, P, HEAULME, M, GONALONS, N, GUEUDET, C, SANTUCCI, V, THURNEYSSEN, O, KEANE, P, GULLY, D, LE FUR, G

“…The activity of SR 27897, a potent and selective CCK-A vs CCK-B receptor antagonist (Ki = 0.2 nM on guinea-pig pancreas vs 2000 nM on rat brain) was studied on…”
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An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site by CHAMBON, J.-P, FELTZ, P, HEAULME, M, RESTLE, S, SCHLICHTER, R, BIZIERE, K, WERMUTH, C. G

“…In view of finding a new gamma-aminobutyric acid (GABA) receptor ligand we synthesized an arylaminopyridazine derivative of GABA, SR 95103…”
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Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats by Perio, A, Chambon, J P, Calassi, R, Heaulme, M, Biziere, K

“…Two amino-phenyl-pyridazine derivatives, SR 41378 and CM 40907, have been reported to antagonize seizures in mice, rats and Papio papio baboons with comparable…”
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Multiple benzodiazepine receptors: evidence of dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives) by Le Fur, G, Mizoule, J, Burgevin, M C, Ferris, O, Heaulme, M, Gauthier, A, Guérémy, C, Uzan, A

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CM 40907: a structurally novel anticonvulsant in mice, rats and baboons by Chambon, J P, Brochard, J, Hallot, A, Heaulme, M, Brodin, R, Roncucci, R, Biziere, K

“…CM 40907 [3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)-pyridazine] is a chemically original compound which possesses the pharmacological properties of a potent,…”
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Specific binding of a phenyl-pyridazinium derivative endowed with GABAA receptor antagonist activity to rat brain by Heaulme, M, Chambon, J P, Leyris, R, Wermuth, C G, Biziere, K

“…SR 95531 has been shown to be a potent, selective, reversible and competitive GABAA antagonist. In the present study we report that (3H)SR 95531 binds with…”
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A 7‐phenyl substituted triazolopyridazine has inverse agonist activity at the benzodiazepine receptor site by Biziere, K., Bourguignon, J.J., Chambon, J.P., Heaulme, M., Perio, A., Tebib, S., Wermuth, C.G.

“…1 To investigate further the structural requirements for benzodiazepine (BZD) receptor ligands, we synthesized SR95195,…”
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In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist by Emonds-Alt, X, Doutremepuich, J D, Heaulme, M, Neliat, G, Santucci, V, Steinberg, R, Vilain, P, Bichon, D, Ducoux, J P, Proietto, V

“…(S)1-(2-[3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)pip eridin-3- yl]ethyl)-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride (SR140333) is a new…”
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The sensitivity of gamma-aminobutyric acid antagonists to thiocyanate is related to the absence of a functional anionic group in their structure by Wermuth, C G, Chambon, J P, Heaulme, M, Melikian, A, Schlewer, G, Leyris, R, Biziére, K

“…Pyridazinyl derivatives of gamma-aminobutyric acid (GABA) have recently been shown to be selective, reversible and competitive GABAA antagonists. Unlike what…”
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35 mM K(+)-stimulated 45Ca2+ uptake in cerebellar granule cell cultures mainly results from NMDA receptor activation by Didier, M, Héaulme, M, Gonalons, N, Soubrié, P, Bockaert, J, Pin, J P

“…In primary cultures of cerebellar granule cells, the Ca2+ influx resulting from K+ depolarization (35 mM) was equal to one-third of that observed with 100…”
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Medical record objectives in relation to clinical problems and user needs by de Heaulme, M

“…The difficulties met when clinical record systems are implemented using a computer have many causes. Some difficulties must be first solved by determining user…”
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Creation and validation of medical data by De Heaulme, M

“…The problems of creating and validating medical data are discussed. These difficulties relate to the structuring of data and its definiton. The necessity for…”
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