Search Results - "Härkönen, Pirkko L"

Adenosine inhibits tumor cell invasion via receptor-independent mechanisms by Virtanen, Sanna S, Kukkonen-Macchi, Anu, Vainio, Minna, Elima, Kati, Härkönen, Pirkko L, Jalkanen, Sirpa, Yegutkin, Gennady G

“…Extracellular adenosine mediates diverse anti-inflammatory, angiogenic, and other signaling effects via binding to adenosine receptors, and it also regulates…”
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Monocyte-Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators by Haerkoenen, Pirkko L, Vaeaenaenen, HKalervo

“…:  Postmenopausal decline of estrogen production is associated with development of several degenerative disorders such as osteoporosis, neuroinflammatory…”
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Regulation of Osteoblast Differentiation: A Novel Function for Fibroblast Growth Factor 8 by Valta, Maija P, Hentunen, Teuvo, Qu, Qiang, Valve, Eeva M, Harjula, Anna, Seppänen, Jani A, Väänänen, H. Kalervo, Härkönen, Pirkko L

“…Several members of the fibroblast growth factor (FGF) family have an important role in the development of skeletal tissues. FGF-8 is widely expressed in the…”
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Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption by Michael, Husheem, Härkönen, Pirkko L, Väänänen, H Kalervo, Hentunen, Teuvo A

“…Using human peripheral blood CD14+ osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological…”
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Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model by Kähkönen, Tiina E., Tuomela, Johanna M., Grönroos, Tove J., Halleen, Jussi M., Ivaska, Kaisa K., Härkönen, Pirkko L.

“…Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance…”
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Role of fibroblast growth factor 8 in growth and progression of hormonal cancer by Mattila, Mirjami M, Härkönen, Pirkko L

“…Abstract Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal…”
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Fibroblast growth factor 8 increases breast cancer cell growth by promoting cell cycle progression and by protecting against cell death by Nilsson, Emeli M., Brokken, Leon J.S., Härkönen, Pirkko L.

“…Fibroblast growth factor 8 (FGF-8) is expressed in a large proportion of breast cancers, whereas its level in normal mammary gland epithelium is low. Previous…”
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Stromal Activation Associated with Development of Prostate Cancer in Prostate-Targeted Fibroblast Growth Factor 8b Transgenic Mice by Elo, Teresa D., Valve, Eeva M., Seppänen, Jani A., Vuorikoski, Heikki J., Mäkelä, Sari I., Poutanen, Matti, Kujala, Paula M., Härkönen, Pirkko L.

“…Expression of fibroblast growth factor 8 (FGF-8) is commonly increased in prostate cancer. Experimental studies have provided evidence that it plays a role in…”
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Rab13 Is Upregulated During Osteoclast Differentiation and Associates with Small Vesicles Revealing Polarized Distribution in Resorbing Cells by Hirvonen, Mirkka J., Mulari, Mika T. K., Büki, Kálmán G., Vihko, Pirkko, Härkönen, Pirkko L., Väänänen, H. Kalervo

“…Osteoclasts are bone-resorbing multinucleated cells that undergo drastic changes in their polarization due to heavy vesicular trafficking during the resorption…”
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FGF-8b induces growth and rich vascularization in an orthotopic PC-3 model of prostate cancer by Valta, Maija P., Tuomela, Johanna, Vuorikoski, Heikki, Loponen, Niina, Väänänen, Riina-Minna, Pettersson, Kim, Väänänen, H. Kalervo, Härkönen, Pirkko L.

“…Fibroblast growth factor 8 (FGF‐8) is expressed at an increased level in a high proportion of prostate cancers and it is associated with a poor prognosis of…”
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Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells by Virtanen, Sanna S., Sandholm, Jouko, Yegutkin, Gennady, Väänänen, Kalervo H., Härkönen, Pirkko L.

“…The mevalonate synthesis pathway produces intermediates for isoprenylation of small GTPases, which are involved in the regulation of actin cytoskeleton and…”
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Carbonic anhydrase III protects cells from hydrogen peroxide‐induced apoptosis by Räisänen, Seija R., Lehenkari, Petri, Tasanen, Merja, Rahkila, Paavo, Härkönen, Pirkko L., Kalervo Väänänen, H.

“…ABSTRACT Carbonic anhydrase III (CA III; EC 4.2.1.1) is a cytoplasmic enzyme that exhibits a relatively low carbon dioxide hydratase activity. It is expressed…”
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PRL Signal Transduction in the Epithelial Compartment of Rat Prostate Maintained as Long-Term Organ Cultures in Vitro by Ahonen, Tommi J, Härkönen, Pirkko L, Rui, Hallgeir, Nevalainen, Marja T

“…Using long-term organ cultures of rat prostate tissue explants, we previously demonstrated that PRL both stimulates proliferation and acts as an…”
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Novel interaction of Rab13 and Rab8 with endospanins by Hirvonen, Mirkka J., Büki, Kálmán G., Sun, Yi, Mulari, Mika T.K., Härkönen, Pirkko L., Väänänen, Kalervo H.

“…Rab GTPases regulate vesicular traffic in eukaryotic cells by cycling between the active GTP-bound and inactive GDP-bound states. Their functions are modulated…”
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Androgen and fibroblast growth factor 8 (FGF8) downregulation of thrombospondin 1 (TSP1) in mouse breast cancer cells by Mattila, Mirjami M., Tarkkonen, Kati M., Seppänen, Jani A., Ruohola, Johanna K., Valve, Eeva M., Härkönen, Pirkko L.

“…In the search for androgen target genes responsible for malignant growth in S115 mouse mammary tumor cells we found that thrombospondin 1 (TSP1) expression was…”
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Alendronate-induced disruption of actin cytoskeleton and inhibition of migration/invasion are associated with cofilin downregulation in PC-3 prostate cancer cells by Virtanen, Sanna S, Ishizu, Tamiko, Sandholm, Jouko A, Löyttyniemi, Eliisa, Väänänen, H Kalervo, Tuomela, Johanna M, Härkönen, Pirkko L

“…Bisphosphonates are used for prevention of osteoporosis and metastatic bone diseases. Anti-invasive effects on various cancer cells have also been reported,…”
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Role of estrogens in development of prostate cancer by Härkönen, Pirkko, Makela, Sari I

“…Estrogens have previously been extensively used in prostate cancer treatment. Serious side effects, primarily in cardiovascular system have, however, limited…”
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The Effects of Tamoxifen and Toremifene on Bone Cells Involve Changes in Plasma Membrane Ion Conductance by Lehenkari, Petri, Parikka, Vilhelmiina, Rautiala, Timo J, Weckström, Matti, Dahllund, Johanna, Härkönen, Pirkko L, Väänänen, H Kalervo

“…Selective estrogen receptor modulators (SERMs), tamoxifen (Tam) and toremifene (Tor), are widely used in the treatment of breast cancer. In addition, they have…”
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Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L by Kaur, Kamaljit, Michael, Husheem, Arora, Saroj, Härkönen, Pirkko L, Kumar, Subodh

“…We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities. The antimutagenic…”
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The in vitro cytotoxic and apoptotic activity of Triphala—an Indian herbal drug by Kaur, Swayamjot, Michael, Husheem, Arora, Saroj, Härkönen, Pirkko L., Kumar, Subodh

“…A study on cytotoxic effect of acetone extract of “Triphala” whose antimutagenicity has already been tested (Kaur S., Arora S., Kaur K., Kumar S., 2002. The in…”
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