Search Results - "Härkönen, P L"

Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes by Kähkönen, T.E., Ivaska, K.K., Jiang, M., Büki, K.G., Väänänen, H.K., Härkönen, P.L.

“…Fibroblast growth factors (FGF) and their receptors (FGFRs) regulate many developmental processes including differentiation of mesenchymal stromal cells (MSC)…”
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Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures by Kähkönen, T. E., Toriseva, M., Petruk, N., Virta, A.-R., Maher, A., Eigéliené, N., Kaivola, J., Boström, P., Koskivuo, I., Nees, M., Tuomela, J. M., Ivaska, K. K., Härkönen, P. L.

“…Purpose Fibroblast growth factor receptors (FGFR) and pathways are important players in breast cancer (BC) development. They are commonly altered, and BCs…”
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Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro by Michael, H, Härkönen, P L, Kangas, L, Väänänen, H K, Hentunen, T A

“…Background and purpose: Several selective oestrogen receptor modulators (SERMs) with oestrogen agonist effects in bone cells and without increased risk of…”
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Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells by Nilsson, E.M., Brokken, L.J.S., Narvi, E., Kallio, M.J., Härkönen, P.L.

“…► FGF-8b is expressed in human breast tumors and it promotes growth of breast cancer cells. ► Using microarray technique we identified FGF-8b-regulated genes…”
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Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis by Gu, G, Hentunen, T A, Nars, M, Härkönen, P L, Väänänen, H K

“…Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in…”
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Conditioned medium of Estrogen-treated osteoblasts inhibits osteoclast maturation and function in vitro by Qu, Q, Härkönen, P.L, Mönkkönen, J, Väänänen, H.K

“…The increase of bone resorption and reduction of bone mass in postmenopausal women can be prevented by treatment with estrogen. Although it is well established…”
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FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells by MATTILA, Mirjami M. T, RUOHOLA, Johanna K, VALVE, Eeva M, TASANEN, Merja J, SEPPANEN, Jani A, HÄRKÖNEN, Pirkko L

“…Fibroblast growth factor 8 (FGF-8) is a secreted heparin-binding protein, which has transforming potential. Alternative splicing of the mouse Fgf-8 gene…”
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Prolactin and prolactin receptors are expressed and functioning in human prostate by Nevalainen, M T, Valve, E M, Ingleton, P M, Nurmi, M, Martikainen, P M, Harkonen, P L

“…Prolactin is widely expressed in different tissues, and it is presumed to have both local and systemic actions. In males it is known to influence reproductive…”
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Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro by Wärri, A M, Huovinen, R L, Laine, A M, Martikainen, P M, Härkönen, P L

“…Antiestrogens inhibit the stimulative effects of estrogens on breast cancer growth, but the mechanism(s) by which they trigger tumor regression are not…”
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Estrogen and bone metabolism by Kalervo Väänänen, H., Härkönen, Pirkko L.

“…Estrogen plays an important role in the growth and maturation of bone as well as in the regulation of bone turnover in adult bone. During bone growth estrogen…”
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Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice by Wärri, A M, Laine, A M, Majasuo, K E, Alitalo, K K, Härkönen, P L

“…Amplification and enhanced expression of the erbB2/HER-2/neu gene has been associated with an increased growth rate and poor prognosis of human breast cancer…”
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Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro by Mulari, M T K, Qu, Q, Härkönen, P L, Väänänen, H K

“…Bone remodeling involves old bone resorption by osteoclasts and new bone formation by osteoblasts. However, the precise cellular mechanisms underlying these…”
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Hormone regulation of human prostate in organ culture by NEVALAINEN, M. T, HÄRKÖNEN, P. L, VALVE, E. M, WU PING, NURMI, M, MARTIKAINEN, P. M

“…We have established organ cultures of human prostate for in vitro analysis of the hormone responsiveness of prostatic carcinoma. Tissue samples were obtained…”
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Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells by Ruohola, Johanna K., Valve, Eeva M., Karkkainen, Marika J., Joukov, Vladimir, Alitalo, Kari, Härkönen, Pirkko L.

“…Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and an important prognostic factor in breast cancer. Hypoxia is an important…”
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Estrogen and prolactin regulation of rat dorsal and lateral prostate in organ culture by Nevalainen, M T, Valve, E M, Mäkelä, S I, Bläuer, M, Tuohimaa, P J, Härkönen, P L

“…Besides androgens, estrogen (E) and PRL are thought to have important roles in the regulation of the growth and function of the prostate. We have established…”
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Carbonic anhydrase III protects cells from hydrogen peroxide‐induced apoptosis by Räisänen, Seija R., Lehenkari, Petri, Tasanen, Merja, Rahkila, Paavo, Härkönen, Pirkko L., Kalervo Väänänen, H.

“…ABSTRACT Carbonic anhydrase III (CA III; EC 4.2.1.1) is a cytoplasmic enzyme that exhibits a relatively low carbon dioxide hydratase activity. It is expressed…”
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Effect of glucose on the major testosterone-maintained protein in the cultured rat ventral prostate by Härkönen, P L, Martikainen, P M, Kostian, M L, Santti, R S

“…The effect of glucose on the androgen-maintained protein synthesis was studied in the cultured rat ventral prostate. The explants were cultivated for 5 days in…”
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Prolactin is a survival factor for androgen-deprived rat dorsal and lateral prostate epithelium in organ culture by Ahonen, T J, Härkönen, P L, Laine, J, Rui, H, Martikainen, P M, Nevalainen, M T

“…PRL is one of several polypeptide factors that regulate growth and differentiation of prostate epithelium besides steroid hormones. This hormone may also…”
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Anti-oestrogen stimulation of ERBB2 ectodomain shedding from BT-474 human breast cancer cells with ERBB2 gene amplification by Wärri, A.M., Isola, J.J., Härkönen, P.l.

“…Oestrogen has previously been shown to downregulate the expression of ERBB2 oncogene in human breast cancer cells, which contain a normal non-amplified ERBB2…”
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Androgen regulation of carbonic anhydrase II, a major soluble protein in rat lateral prostate tissue by HARKONEN, P. L, VAANANEN, H. K

“…The distribution of carbonic anhydrase isoenzymes I and II in rat accessory sex glands was studied by use of immunohistochemistry. Carbonic anhydrase I could…”
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