Search Results - "Häkkinen, Merja R."

Simultaneous analysis by LC–MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue by Häkkinen, Merja R., Murtola, Teemu, Voutilainen, Raimo, Poutanen, Matti, Linnanen, Tero, Koskivuori, Johanna, Lakka, Timo, Jääskeläinen, Jarmo, Auriola, Seppo

“…•Validated LC–MS/MS method for quantifying 23 steroids.•150 μl of plasma, serum or prostatic tissue homogenate.•LLOQs ranged from 0.9 to 91 pg/ml, and from…”
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A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair by Koskivuori, Johanna, Voutilainen, Raimo, Uusitalo, Lauri, Lehtonen, Marko, Lakka, Timo, Auriola, Seppo, Häkkinen, Merja R.

“…Hair steroid analysis offers the possibility to evaluate long-term steroid metabolism. It is especially beneficial when studying the steroid milieu in newborns…”
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Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism by Koskivuori, Johanna, Voutilainen, Raimo, Storvik, Markus, Häkkinen, Merja R., Uusitalo, Lauri, Keski-Nisula, Leea, Backman, Katri, Auriola, Seppo, Lehtonen, Marko

“…Previous steroid hormone studies concerning pregnancy and newborns have mainly focused on glucocorticoids; wider steroid profiles have been less commonly…”
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Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study by Liimatta, Jani, Flück, Christa E, Mäntyselkä, Aino, Häkkinen, Merja R, Auriola, Seppo, Voutilainen, Raimo, Jääskeläinen, Jarmo, Lakka, Timo A

“…Abstract Context Childhood overweight has been linked to earlier development of adrenarche and puberty, but it remains unknown if lifestyle interventions…”
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"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling by Klåvus, Anton, Kokla, Marietta, Noerman, Stefania, Koistinen, Ville M, Tuomainen, Marjo, Zarei, Iman, Meuronen, Topi, Häkkinen, Merja R, Rummukainen, Soile, Farizah Babu, Ambrin, Sallinen, Taisa, Kärkkäinen, Olli, Paananen, Jussi, Broadhurst, David, Brunius, Carl, Hanhineva, Kati

“…Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics in…”
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Nanocrystal-based per-oral itraconazole delivery: Superior in vitro dissolution enhancement versus Sporanox® is not realized in in vivo drug absorption by Sarnes, Annika, Kovalainen, Miia, Häkkinen, Merja R., Laaksonen, Timo, Laru, Johanna, Kiesvaara, Juha, Ilkka, Jukka, Oksala, Olli, Rönkkö, Seppo, Järvinen, Kristiina, Hirvonen, Jouni, Peltonen, Leena

“…Nanoscience holds true promise in enabling efficient formulation development and in vivo delivery of poorly water soluble drugs. The objective of this study…”
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Detection of prostate cancer by an electronic nose: a proof of principle study by Roine, Antti, Veskimäe, Erik, Tuokko, Antti, Kumpulainen, Pekka, Koskimäki, Juha, Keinänen, Tuomo A, Häkkinen, Merja R, Vepsäläinen, Jouko, Paavonen, Timo, Lekkala, Jukka, Lehtimäki, Terho, Tammela, Teuvo L, Oksala, Niku K J

“…We evaluate the ability of an electronic nose to discriminate prostate cancer from benign prostatic hyperplasia using urine headspace, potentially offering a…”
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Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions by Huhtinen, Kaisa, Saloniemi-Heinonen, Taija, Keski-Rahkonen, Pekka, Desai, Reena, Laajala, Daniel, Ståhle, Mia, Häkkinen, Merja R, Awosanya, Michael, Suvitie, Pia, Kujari, Harry, Aittokallio, Tero, Handelsman, David J, Auriola, Seppo, Perheentupa, Antti, Poutanen, Matti

“…Context: Aberrant sex steroid signaling is suggested to promote endometriosis growth by several mechanisms, and the tissue concentrations of sex steroids are…”
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Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model by Xanthoulea, Sofia, Konings, Gonda F.J., Saarinen, Niina, Delvoux, Bert, Kooreman, Loes F.S., Koskimies, Pasi, Häkkinen, Merja R., Auriola, Seppo, D'Avanzo, Elisabetta, Walid, Youssef, Verhaegen, Frank, Lieuwes, Natasja G., Caiment, Florian, Kruitwagen, Roy, Romano, Andrea

“…Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC…”
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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial by Raittinen, Paavo V.H., Syvälä, Heimo, Tammela, Teuvo L.J., Häkkinen, Merja R., Ilmonen, Pauliina, Auriola, Seppo, Murtola, Teemu J.

“…Prostate cancer (PCa) progression depends on androgen receptor activity. Cholesterol is required for biosynthesis of all steroid hormones, including androgens…”
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Altered Polyamine Profiles in Colorectal Cancer by Venäläinen, Markus K, Roine, Antti N, Häkkinen, Merja R, Vepsäläinen, Jouko J, Kumpulainen, Pekka S, Kiviniemi, Mikko S, Lehtimäki, Terho, Oksala, Niku K, Rantanen, Tuomo K

“…The declining mortality rate of patients with colorectal cancer (CRC) can be explained, at least partially, with early diagnosis. Simple diagnostic methods are…”
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A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine by Puris, Elena, Pasanen, Markku, Gynther, Mikko, Häkkinen, Merja R., Pihlajamäki, Jussi, Keränen, Tapani, Honkakoski, Paavo, Raunio, Hannu, Petsalo, Aleksanteri

“…Cocktail phenotyping using specific probe drugs for cytochrome P450 (CYP) enzymes provides information on the real-time activity of multiple CYPs. We…”
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Urinary Polyamines as Biomarkers for Ovarian Cancer by Niemi, Riikka Johanna, Roine, Antti N, Häkkinen, Merja R, Kumpulainen, Pekka S, Keinänen, Tuomo A, Vepsäläinen, Jouko J, Lehtimäki, Terho, Oksala, Niku K, Mäenpää, Johanna U

“…Elevated concentrations of polyamines have been found in urine of patients with malignant tumors, including ovarian cancer. Previous research has suffered from…”
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Blood steroids are associated with prognosis and fat distribution in endometrial cancer by Tangen, Ingvild L., Fasmer, Kristine E., Konings, Gonda F., Jochems, Arthur, Delvoux, Bert, Xanthoulea, Sofia, Stokowy, Tomasz, Strand, Elin, Berg, Hege F., Auriola, Seppo, Trovik, Jone, Häkkinen, Merja R., Haldorsen, Ingfrid S., Krakstad, Camilla, Romano, Andrea

“…Despite being a hormone dependent cancer, there is limited knowledge regarding the relation between level of steroids in blood and prognosis for endometrial…”
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Human Testicular Peritubular Cells Host Putative Stem Leydig Cells With Steroidogenic Capacity by Landreh, Luise, Spinnler, Katrin, Schubert, Kerstin, Häkkinen, Merja R, Auriola, Seppo, Poutanen, Matti, Söder, Olle, Svechnikov, Konstantin, Mayerhofer, Artur

“…Aim: We aim to examine the steroidogenic phenotype and the differentiation potential of human testicular peritubular cells (HTPCs) and to explore their…”
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Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood by Mäntyselkä, Aino, Haapala, Eero A, Lindi, Virpi, Häkkinen, Merja R, Auriola, Seppo, Jääskeläinen, Jarmo, Lakka, Timo A

“…Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of…”
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Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel by Nissinen, Samuli I., Venäläinen, Markus, Kumpulainen, Pekka, Roine, Antti, Häkkinen, Merja R., Vepsäläinen, Jouko, Oksala, Niku, Rantanen, Tuomo

“…Backround Polyamines play an important role in cellular proliferation, and the change in polyamine metabolism is reported in various cancers. We searched for…”
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Analysis by LC–MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue by Häkkinen, Merja R., Heinosalo, Taija, Saarinen, Niina, Linnanen, Tero, Voutilainen, Raimo, Lakka, Timo, Jääskeläinen, Jarmo, Poutanen, Matti, Auriola, Seppo

“…•Validated LC–MS/MS method to analyze 14 steroids.•150 μl of serum, plasma, endometrium or endometriosis tissue homogenate.•E2, E1, T, A4, 17OHP5, 17OHP4,…”
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Controlling of N -alkylpolyamine analogue metabolism by selective deuteration by Ucal, Sebahat, Häkkinen, Merja R, Alanne, Aino-Liisa, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Hyvönen, Mervi T

“…Replacing protium with deuterium is an efficient method to modulate drug metabolism. -alkylated polyamine analogues are polyamine antimetabolites with proven…”
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