Search Results - "Häbe, Tim T."

Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry by Häbe, Tim T, Liu, Chang, Covey, Tom R, Simon, Roman P, Reindl, Wolfgang, Büttner, Frank H, Winter, Martin, Bischoff, Daniel, Luippold, Andreas H, Runge, Frank

“…We present an acoustic ejection mass spectrometry (AEMS) setup for contactless electrospray ionization mass spectrometry (ESI-MS)-based sample injection at a…”
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Microfabrication, separations, and detection by mass spectrometry on ultrathin-layer chromatography plates prepared via the low-pressure chemical vapor deposition of silicon nitride onto carbon nanotube templates by Kanyal, Supriya S., Häbe, Tim T., Cushman, Cody V., Dhunna, Manan, Roychowdhury, Tuhin, Farnsworth, Paul B., Morlock, Gertrud E., Linford, Matthew. R.

“…•UTLC plates prepared by low-pressure CVD of SiNx onto carbon nanotube templates.•Very fast separations.•Detailed method development.•Plates show a high degree…”
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Open‐source add‐on kit for automation of zone elution in planar chromatography by Häbe, Tim T., Morlock, Gertrud E.

“…Rationale High‐throughput capacity, maximal efficiency and automation are missing key features for thin‐layer chromatography/high‐performance thin‐layer…”
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Direct bioautography hyphenated to direct analysis in real time mass spectrometry: Chromatographic separation, bioassay and mass spectra, all in the same sample run by Häbe, Tim T., Jamshidi-Aidji, Maryam, Macho, Jennifer, Morlock, Gertrud E.

“…•Recording of DART-MS spectra in situ the bioautogram at the nanogram-per-band level•Analyte desorption/ionization in presence of microorganisms and bioassay…”
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Profiling and classification of French propolis by combined multivariate data analysis of planar chromatograms and scanning direct analysis in real time mass spectra by Chasset, Thibaut, Häbe, Tim T., Ristivojevic, Petar, Morlock, Gertrud E.

“…•Profiling of French propolis by PCA of HPTLC-FLD image and HPTLC-DART-MS data.•Improved quality control strategy for the classification of propolis…”
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Tracking and identification of antibacterial components in the essential oil of Tanacetum vulgare L. by the combination of high-performance thin-layer chromatography with direct bioautography and mass spectrometry by Móricz, Ágnes M., Häbe, Tim T., Böszörményi, Andrea, Ott, Péter G., Morlock, Gertrud E.

“…•Bioactivity profiling of two tansy (Tanacetum vulgare L.) essential oils.•First direct bioautography (DB) using potato and tomato pathogen Ralstonia…”
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Comparison of high-performance thin-layer with overpressured layer chromatography combined with direct bioautography and direct analysis in real time mass spectrometry for tansy root by Móricz, Ágnes M., Häbe, Tim T., Ott, Péter G., Morlock, Gertrud E.

“…•Comparison of HPTLC-EDA with OPLC-EDA for tansy root.•First time combination of OPLC and scanning DART-HRMS.•OPLC-DART-HRMS using irregular versus spherical…”
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Office Chromatography: Precise printing of sample solutions on miniaturized thin-layer phases and utilization for scanning Direct Analysis in Real Time mass spectrometry by Häbe, Tim T., Morlock, Gertrud E.

“…Office Chromatography combines achievements in office technologies with miniaturized planar chromatography. In the life sciences, printing of materials became…”
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Improved desorption/ionization and ion transmission in surface scanning by direct analysis in real time mass spectrometry by Häbe, Tim T., Morlock, Gertrud E.

“…Rationale Modifications to the Direct Analysis in Real Time mass spectrometry (DART‐MS) interface, its source cap and transfer tube were necessary to obtain…”
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Effect-Directed Discovery of Bioactive Compounds Followed by Highly Targeted Characterization, Isolation and Identification, Exemplarily Shown for Solidago virgaurea by Móricz, Ágnes M, Ott, Péter G, Häbe, Tim T, Darcsi, András, Böszörményi, Andrea, Alberti, Ágnes, Krüzselyi, Dániel, Csontos, Péter, Béni, Szabolcs, Morlock, Gertrud E

“…A nontargeted, effect-directed screening (bioprofiling) and a subsequent highly targeted characterization of antibacterial compounds from plant matrices is…”
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An ultrafast and flexible liquid chromatography/tandem mass spectrometry system paves the way for machine learning driven in vivo sample processing in early drug discovery by Häbe, Tim T., Späth, Christian, Schrade, Steffen, Jörg, Wolfgang, Süssmuth, Roderich D., Bischoff, Daniel, Luippold, Andreas H.

“…Rationale The low speed and low flexibility of most liquid chromatography/tandem mass spectrometry (LC/MS/MS) approaches in early drug discovery delay sample…”
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Quantitative surface scanning by Direct Analysis in Real Time mass spectrometry by Häbe, Tim T., Morlock, Gertrud E.

“…RATIONALE Only a few ambient ionization sources have been demonstrated to work quantitatively for surface scanning. A modification of the Direct Analysis in…”
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Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery by Simon, Roman P, Häbe, Tim T, Ries, Robert, Winter, Martin, Wang, Yuting, Fernández-Montalván, Amaury, Bischoff, Daniel, Runge, Frank, Reindl, Wolfgang, Luippold, Andreas H, Büttner, Frank H

“…Acoustic droplet ejection (ADE)-open port interface (OPI)-mass spectrometry (MS) has recently been introduced as a versatile analytical method that combines…”
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Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice by Winter, Martin, Simon, Roman P., Häbe, Tim T., Ries, Robert, Wang, Yuting, Kvaskoff, David, Fernández-Montalván, Amaury, Luippold, Andreas H., Büttner, Frank H., Reindl, Wolfgang

“…Acoustic droplet ejection-open port interface-mass spectrometry (ADE-OPI-MS) is a novel label-free analytical technique, promising to become a versatile…”
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MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein-Ligand Interactions at High Throughput by Simon, Roman P, Winter, Martin, Kleiner, Carola, Wehrle, Lucie, Karnath, Michael, Ries, Robert, Zeeb, Markus, Schnapp, Gisela, Fiegen, Dennis, Häbe, Tim T, Runge, Frank, Bretschneider, Tom, Luippold, Andreas H, Bischoff, Daniel, Reindl, Wolfgang, Büttner, Frank H

“…Demonstration of in vitro target engagement for small-molecule ligands by measuring binding to a molecular target is an established approach in early drug…”
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Miniaturization of Instrumental Planar Chromatography with Focus on Mass Spectrometry by Häbe, Tim T., Morlock, Gertrud E.

“…The universal trends to miniaturization and to automation of technologies affect the further development of analytical instrumentation and methodologies. In…”
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