Search Results - "Hável, J"

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy by Havel, Jonathan J., Chowell, Diego, Chan, Timothy A.

“…Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1 (PD1) pathway have achieved…”
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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer by Rizvi, Naiyer A., Hellmann, Matthew D., Snyder, Alexandra, Kvistborg, Pia, Makarov, Vladimir, Havel, Jonathan J., Lee, William, Yuan, Jianda, Wong, Phillip, Ho, Teresa S., Miller, Martin L., Rekhtman, Natasha, Moreira, Andre L., Ibrahim, Fawzia, Bruggeman, Cameron, Gasmi, Billel, Zappasodi, Roberta, Maeda, Yuka, Sander, Chris, Garon, Edward B., Merghoub, Taha, Wolchok, Jedd D., Schumacher, Ton N., Chan, Timothy A.

“…Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants…”
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The role of neoantigens in response to immune checkpoint blockade by Riaz, Nadeem, Morris, Luc, Havel, Jonathan J, Makarov, Vladimir, Desrichard, Alexis, Chan, Timothy A

“…Immune checkpoint blockade has demonstrated substantial promise for the treatment of several advanced malignancies. These agents activate the immune system to…”
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A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults by Stanhope, Kimber L, Medici, Valentina, Bremer, Andrew A, Lee, Vivien, Lam, Hazel D, Nunez, Marinelle V, Chen, Guoxia X, Keim, Nancy L, Havel, Peter J

“…National Health and Nutrition Examination Survey data show an increased risk of cardiovascular disease (CVD) mortality with an increased intake of added sugar…”
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Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions by Dalin, Martin G., Katabi, Nora, Persson, Marta, Lee, Ken-Wing, Makarov, Vladimir, Desrichard, Alexis, Walsh, Logan A., West, Lyndsay, Nadeem, Zaineb, Ramaswami, Deepa, Havel, Jonathan J., Kuo, Fengshen, Chadalavada, Kalyani, Nanjangud, Gouri J., Ganly, Ian, Riaz, Nadeem, Ho, Alan L., Antonescu, Cristina R., Ghossein, Ronald, Stenman, Göran, Chan, Timothy A., Morris, Luc G. T.

“…Myoepithelial carcinoma (MECA) is an aggressive salivary gland cancer with largely unknown genetic features. Here we comprehensively analyze molecular…”
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Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys by Blevins, James E, Graham, James L, Morton, Gregory J, Bales, Karen L, Schwartz, Michael W, Baskin, Denis G, Havel, Peter J

“…Despite compelling evidence that oxytocin (OT) is effective in reducing body weight (BW) in diet-induced obese (DIO) rodents, studies of the effects of OT in…”
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The head and neck cancer immune landscape and its immunotherapeutic implications by Mandal, Rajarsi, Şenbabaoğlu, Yasin, Desrichard, Alexis, Havel, Jonathan J, Dalin, Martin G, Riaz, Nadeem, Lee, Ken-Wing, Ganly, Ian, Hakimi, A Ari, Chan, Timothy A, Morris, Luc Gt

“…Recent clinical trials have demonstrated a clear survival advantage in advanced head and neck squamous cell carcinoma (HNSCC) patients treated with immune…”
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Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin by Havel, Peter J

“…Adipose tissue performs complex metabolic and endocrine functions. This review will focus on the recent literature on the biology and actions of three…”
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Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism by Havel, Peter J

“…Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. This…”
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Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance by Stanhope, Kimber L, Havel, Peter J

“…Based on interim results from an ongoing study, we have reported that consumption of a high-fructose diet, but not a high-glucose diet, promotes the…”
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Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women by Stanhope, Kimber L, Bremer, Andrew A, Medici, Valentina, Nakajima, Katsuyuki, Ito, Yasuki, Nakano, Takamitsu, Chen, Guoxia, Fong, Tak Hou, Lee, Vivien, Menorca, Roseanne I, Keim, Nancy L, Havel, Peter J

“…Context: The American Heart Association Nutrition Committee recommends women and men consume no more than 100 and 150 kcal of added sugar per day,…”
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Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis by Havel, P J

“…Numerous peripheral signals contribute to the regulation of food intake and energy homeostasis. Mechano- and chemoreceptors signaling the presence and energy…”
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Lipoprotein(a) and diet: consuming sugar-sweetened beverages lowers lipoprotein(a) levels in obese and overweight adults by Law, Hayley G., Stanhope, Kimber L., Zhang, Wei, Myagmarsuren, Munkhtuya, Jamshed, Zahraa M., Khan, Muhammad A., Bang, Heejung, Havel, Peter J., Berglund, Lars, Enkhmaa, Byambaa

“…Lipoprotein(a) [Lp(a)] contributes to cardiovascular disease risk. A genetically determined size polymorphism in apolipoprotein(a) [apo(a)], determined by the…”
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Chronic stress increases vulnerability to diet-related abdominal fat, oxidative stress, and metabolic risk by Aschbacher, Kirstin, Kornfeld, Sarah, Picard, Martin, Puterman, Eli, Havel, Peter J, Stanhope, Kimber, Lustig, Robert H, Epel, Elissa

“…Summary Background In preclinical studies, the combination of chronic stress and a high sugar/fat diet is a more potent driver of visceral adiposity than diet…”
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Lipoprotein lipase is active as a monomer by Beigneux, Anne P., Allan, Christopher M., Sandoval, Norma P., Cho, Geoffrey W., Heizer, Patrick J., Jung, Rachel S., Stanhope, Kimber L., Havel, Peter J., Birrane, Gabriel, Meiyappan, Muthuraman, Gill, John E., Murakami, Masami, Miyashita, Kazuya, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G.

“…Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this…”
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Triglyceride-Rich Lipoproteins and Plasma Lipid Transport by Havel, Richard J

“…This memoir provides a history of the triglyceride-rich lipoproteins of blood plasma over the last half-century. As precursors of low-density lipoproteins and…”
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Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway by Havel, J J, Li, Z, Cheng, D, Peng, J, Fu, H

“…The ribosomal protein (RP)-HDM2-p53 pathway has been shown to have key roles in oncogene-induced apoptosis and senescence, but the mechanism regulating this…”
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Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight obese men and women by Cox, C L, Stanhope, K L, Schwarz, J M, Graham, J L, Hatcher, B, Griffen, S C, Bremer, A A, Berglund, L, McGahan, J P, Havel, P J, Keim, N L

“…Background/Objectives: The results of short-term studies in humans suggest that, compared with glucose, acute consumption of fructose leads to increased…”
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Interindividual Variability in Postprandial Plasma Fructose Patterns in Adults by Gladding, Mia, Shen, Xiaotao, Snyder, Michael P, Havel, Peter J, Adams, Sean H

“…High fructose consumption is associated with an increased risk of cardiometabolic disease, and fructose feeding dose-dependently induces markers reflective of…”
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Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex by CNOP, M, HAVEL, P. J, UTZSCHNEIDER, K. M, CARR, D. B, SINHA, M. K, BOYKO, E. J, RETZLAFF, B. M, KNOPP, R. H, BRUNZELL, J. D, KAHN, S. E

“…Increased intra-abdominal fat is associated with insulin resistance and an atherogenic lipoprotein profile. Circulating concentrations of adiponectin, an…”
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