Search Results - "Hàjek, Roman"

Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN) by Palumbo, Antonio, Bringhen, Sara, Ludwig, Heinz, Dimopoulos, Meletios A., Bladé, Joan, Mateos, Maria V., Rosiñol, Laura, Boccadoro, Mario, Cavo, Michele, Lokhorst, Henk, Zweegman, Sonja, Terpos, Evangelos, Davies, Faith, Driessen, Christoph, Gimsing, Peter, Gramatzki, Martin, Hàjek, Roman, Johnsen, Hans E., Leal Da Costa, Fernando, Sezer, Orhan, Spencer, Andrew, Beksac, Meral, Morgan, Gareth, Einsele, Hermann, San Miguel, Jesus F., Sonneveld, Pieter

“…Most patients with newly diagnosed multiple myeloma (MM) are aged > 65 years with 30% aged > 75 years. Many elderly patients are also vulnerable because of…”
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TGF-β - an excellent servant but a bad master by Kubiczkova, Lenka, Sedlarikova, Lenka, Hajek, Roman, Sevcikova, Sabina

“…The transforming growth factor (TGF-β) family of growth factors controls an immense number of cellular responses and figures prominently in development and…”
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Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study by Dimopoulos, Meletios A, Prof, Moreau, Philippe, Prof, Palumbo, Antonio, Prof, Joshua, Douglas, Prof, Pour, Ludek, Prof, Hájek, Roman, Prof, Facon, Thierry, Prof, Ludwig, Heinz, Prof, Oriol, Albert, Prof, Goldschmidt, Hartmut, Prof, Rosiñol, Laura, Prof, Straub, Jan, Prof, Suvorov, Aleksandr, Prof, Araujo, Carla, Prof, Rimashevskaya, Elena, Prof, Pika, Tomas, Prof, Gaidano, Gianluca, Prof, Weisel, Katja, Prof, Goranova-Marinova, Vesselina, Prof, Schwarer, Anthony, Prof, Minuk, Leonard, Prof, Masszi, Tamás, Prof, Karamanesht, Ievgenii, Prof, Offidani, Massimo, Prof, Hungria, Vania, Prof, Spencer, Andrew, Prof, Orlowski, Robert Z, MD, Gillenwater, Heidi H, MD, Mohamed, Nehal, PhD, Feng, Shibao, PhD, Chng, Wee-Joo, Prof

“…Summary Background Bortezomib with dexamethasone is a standard treatment option for relapsed or refractory multiple myeloma. Carfilzomib with dexamethasone has…”
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Third dose of COVID‐19 vaccine restores immune response in patients with haematological malignancies after loss of protective antibody titres by Šušol, Ondrej, Hájková, Barbora, Zelená, Hana, Hájek, Roman

“…Summary We have vaccinated 392 patients with two doses of mRNA COMIRNATY vaccine with an overall antibody response of 70% (best in cMPN, worst in CLL). We have…”
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Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma by Jelinek, Tomas, Paiva, Bruno, Hajek, Roman

“…The treatment of cancer, especially of various types of solid tumors, has been revolutionized by the blockade of the PD-1/PD-L1 pathway by immune checkpoint…”
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Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis by Kastritis, Efstathios, Leleu, Xavier, Arnulf, Bertrand, Zamagni, Elena, Cibeira, María Teresa, Kwok, Fiona, Mollee, Peter, Hájek, Roman, Moreau, Philippe, Jaccard, Arnaud, Schönland, Stefan O, Filshie, Robin, Nicolas-Virelizier, Emmanuelle, Augustson, Bradley, Mateos, María-Victoria, Wechalekar, Ashutosh, Hachulla, Eric, Milani, Paolo, Dimopoulos, Meletios A, Fermand, Jean-Paul, Foli, Andrea, Gavriatopoulou, Maria, Klersy, Catherine, Palumbo, Antonio, Sonneveld, Pieter, Johnsen, Hans Erik, Merlini, Giampaolo, Palladini, Giovanni

“…Oral melphalan and dexamethasone (MDex) were considered a standard of care in light-chain (AL) amyloidosis. In the past decade, bortezomib has been…”
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Hydrophilic interaction liquid chromatography⿿mass spectrometry of (lyso)phosphatidic acids, (lyso)phosphatidylserines and other lipid classes by Cifkova, Eva, Hajek, Roman, Lisa, Miroslav, Holcapek, Michal

“…⿢Optimization of HILIC separation of (lyso)phosphatidylserines, (lyso)phosphatidic acids and other lipids.⿢Acidobasic properties of lipids are correlated with…”
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Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry Characterization of Gangliosides in Biological Samples by Hájek, Roman, Jirásko, Robert, Lísa, Miroslav, Cífková, Eva, Holčapek, Michal

“…The hydrophilic interaction liquid chromatography (HILIC) coupled to a negative-ion electrospray ionization tandem mass spectrometry (ESI-MS/MS) method has…”
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Monoclonal antibodies in the treatment of AL amyloidosis: co‐targetting the plasma cell clone and amyloid deposits by Popkova, Tereza, Hajek, Roman, Jelinek, Tomas

“…Summary Immunoglobulin light‐chain amyloidosis (AL amyloidosis) is a rare disease in which a small plasma cell clone produces toxic misfolded proteins that…”
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Proteasome inhibitors – molecular basis and current perspectives in multiple myeloma by Kubiczkova, Lenka, Pour, Ludek, Sedlarikova, Lenka, Hajek, Roman, Sevcikova, Sabina

“…Inhibition of proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, has emerged as a powerful strategy for treatment of…”
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Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma by Avet-Loiseau, Hervé, Fonseca, Rafael, Siegel, David, Dimopoulos, Meletios A., Špička, Ivan, Masszi, Tamás, Hájek, Roman, Rosiñol, Laura, Goranova-Marinova, Vesselina, Mihaylov, Georgi, Maisnar, Vladimír, Mateos, Maria-Victoria, Wang, Michael, Niesvizky, Ruben, Oriol, Albert, Jakubowiak, Andrzej, Minarik, Jiri, Palumbo, Antonio, Bensinger, William, Kukreti, Vishal, Ben-Yehuda, Dina, Stewart, A.Keith, Obreja, Mihaela, Moreau, Philippe

“…The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact…”
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Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report by Palumbo, Antonio, Bringhen, Sara, Mateos, Maria-Victoria, Larocca, Alessandra, Facon, Thierry, Kumar, Shaji K., Offidani, Massimo, McCarthy, Philip, Evangelista, Andrea, Lonial, Sagar, Zweegman, Sonja, Musto, Pellegrino, Terpos, Evangelos, Belch, Andrew, Hajek, Roman, Ludwig, Heinz, Stewart, A. Keith, Moreau, Philippe, Anderson, Kenneth, Einsele, Hermann, Durie, Brian.G.M., Dimopoulos, Meletios A., Landgren, Ola, San Miguel, Jesus F., Richardson, Paul, Sonneveld, Pieter, Rajkumar, S. Vincent

“…We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been…”
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Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial by Dimopoulos, Meletios A, Špička, Ivan, Quach, Hang, Oriol, Albert, Hájek, Roman, Garg, Mamta, Beksac, Meral, Bringhen, Sara, Katodritou, Eirini, Chng, Wee-Joo, Leleu, Xavier, Iida, Shinsuke, Mateos, María-Victoria, Morgan, Gareth, Vorog, Alexander, Labotka, Richard, Wang, Bingxia, Palumbo, Antonio, Lonial, Sagar

“…Maintenance therapy prolongs progression-free survival (PFS) in patients with newly diagnosed multiple myeloma (NDMM) not undergoing autologous stem cell…”
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An economic evaluation of the effectiveness of telemedicine in hematooncology by Lebiedzik, Marian, Tureckova, Kamila, Majerova, Ingrid, Nevima, Jan, Hradská, Katarína, Popková, Tereza, Skorupová, Michaela, Hájek, Roman

“…The article examines the effectiveness of remote monitoring and the evaluation of facts about patients with hematologic malignancies using telemedicine based…”
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Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma by Stewart, A. Keith, Rajkumar, S. Vincent, Dimopoulos, Meletios A, Masszi, Tamás, Špička, Ivan, Oriol, Albert, Hájek, Roman, Rosiñol, Laura, Siegel, David S, Mihaylov, Georgi G, Goranova-Marinova, Vesselina, Rajnics, Péter, Suvorov, Aleksandr, Niesvizky, Ruben, Jakubowiak, Andrzej J, San-Miguel, Jesus F, Ludwig, Heinz, Wang, Michael, Maisnar, Vladimír, Minarik, Jiri, Bensinger, William I, Mateos, Maria-Victoria, Ben-Yehuda, Dina, Kukreti, Vishal, Zojwalla, Naseem, Tonda, Margaret E, Yang, Xinqun, Xing, Biao, Moreau, Philippe, Palumbo, Antonio

“…In this study, the addition of carfilzomib to lenalidomide and dexamethasone improved response rates and overall survival among patients with relapsed multiple…”
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Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility by Celichowski, Piotr, Turi, Marcello, Charvátová, Sandra, Radhakrishnan, Dhwani, Feizi, Neda, Chyra, Zuzana, Šimíček, Michal, Jelínek, Tomáš, Bago, Juli Rodriguez, Hájek, Roman, Hrdinka, Matouš

“…Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and…”
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Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma by Hajek, Roman, Okubote, Samuel A., Svachova, Hana

“…Summary Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although…”
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Multiple Myeloma: EHA‐ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow‐up by Dimopoulos, Meletios A., Moreau, Philippe, Terpos, Evangelos, Mateos, María‐Victoria, Zweegman, Sonja, Cook, Gordon, Delforge, Michel, Hájek, Roman, Schjesvold, Fredrik, Cavo, Michele, Goldschmidt, Hartmut, Facon, Thierry, Einsele, Hermann, Boccadoro, Mario, San‐Miguel, Jesús, Sonneveld, Pieter, Mey, Ulrich

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Lipidomic characterization of exosomes isolated from human plasma using various mass spectrometry techniques by Peterka, Ondřej, Jirásko, Robert, Chocholoušková, Michaela, Kuchař, Ladislav, Wolrab, Denise, Hájek, Roman, Vrána, David, Strouhal, Ondřej, Melichar, Bohuslav, Holčapek, Michal

“…Ultrahigh-performance supercritical fluid chromatography - mass spectrometry (UHPSFC/MS), ultrahigh-performance liquid chromatography - mass spectrometry…”
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Promising Immunotherapeutic Modalities for B-Cell Lymphoproliferative Disorders by Mihályová, Jana, Hradská, Katarína, Jelínek, Tomáš, Motais, Benjamin, Celichowski, Piotr, Hájek, Roman

“…Over the last few years, treatment principles have been changed towards more targeted therapy for many B-cell lymphoma subtypes and in chronic lymphocytic…”
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