Search Results - "HÜTTL, MARTINA"

In a Prediabetic Model, Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia by Hüttl, Martina, Markova, Irena, Miklankova, Denisa, Zapletalova, Iveta, Poruba, Martin, Haluzik, Martin, Vaněčkova, Ivana, Malinska, Hana

“…Recent studies suggest that treatment with SGLT-2 inhibitors can reduce hepatic lipid storage and ameliorate non-alcoholic fatty liver disease (NAFLD)…”
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Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model by Miklankova, Denisa, Markova, Irena, Hüttl, Martina, Zapletalova, Iveta, Poruba, Martin, Malinska, Hana

“…Metformin can reduce cardiovascular risk independent of glycemic control. The mechanisms behind its non-glycemic benefits, which include decreased energy…”
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Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome by Malinska, Hana, Hüttl, Martina, Oliyarnyk, Olena, Markova, Irena, Poruba, Martin, Racova, Zuzana, Kazdova, Ludmila, Vecera, Rostislav

“…Troxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently,…”
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CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study by Silhavy, Jan, Mlejnek, Petr, Šimáková, Miroslava, Marková, Irena, Malínská, Hana, Hüttl, Martina, Kazdová, Ludmila, Kazantsev, Dmitry, Mancini, Massimiliano, Novotný, Jiří, Pravenec, Michal

“…Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of…”
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Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia by Malinská, Hana, Hüttl, Martina, Miklánková, Denisa, Trnovská, Jaroslava, Zapletalová, Iveta, Poruba, Martin, Marková, Irena

“…Ovarian hormone deficiency leads to increased body weight, visceral adiposity, fatty liver and disorders associated with menopausal metabolic syndrome. To…”
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Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose by Senko, Anna N, Overall, Rupert W, Silhavy, Jan, Mlejnek, Petr, Malínská, Hana, Hüttl, Martina, Marková, Irena, Fabel, Klaus S, Lu, Lu, Stuchlik, Ales, Williams, Robert W, Pravenec, Michal, Kempermann, Gerd

“…Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases…”
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Empagliflozin alters lipid metabolism in the myocardium and liver in a prediabetes model with severe dyslipidemia by Miklankova, Denisa, Markova, Irena, Hüttl, Martina, Malinska, Hana

“…Recent studies suggest that empagliflozin reduces total and cardiovascular mortality in both diabetic and nondiabetic subjects. Although the exact mechanism is…”
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Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension by Hojná, Silvie, Rauchová, Hana, Malínská, Hana, Marková, Irena, Hüttl, Martina, Papoušek, František, Behuliak, Michal, Miklánková, Denisa, Vaňourková, Zdeňka, Neckář, Jan, Kadlecová, Michaela, Kujal, Petr, Zicha, Josef, Vaněčková, Ivana

“…The new antidiabetic drugs, gliflozins, inhibit sodium-glucose transporter-2 in renal proximal tubules promoting glucose and sodium excretion. This leads not…”
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Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats by Świętek, Małgorzata, Marková, Irena, Malínská, Hana, Hüttl, Martina, Miklánková, Denisa, Černá, Kristýna, Konefał, Rafał, Horák, Daniel

“…Magnetic nanoparticles (MNPs) modified with tannic acid (TA) have shown remarkable success as an antioxidant and antimicrobial therapeutic agent. Herein, we…”
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Hepatoprotective and cardioprotective effects of empagliflozin in spontaneously hypertensive rats fed a high-fat diet by Hojná, Silvie, Malínská, Hana, Hüttl, Martina, Vaňourková, Zdeňka, Marková, Irena, Miklánková, Denisa, Hrdlička, Jaroslav, Papoušek, František, Neckář, Jan, Kujal, Petr, Behuliak, Michal, Rauchová, Hana, Kadlecová, Michaela, Sedmera, David, Neffeová, Kristýna, Zábrodská, Eva, Olejníčková, Veronika, Zicha, Josef, Vaněčková, Ivana

“…A combination of liver and heart dysfunction worsens the prognosis of human survival. The aim of this study was to investigate whether empagliflozin (a…”
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Quercetin supplementation in metabolic syndrome: nutrigenetic interactions with the Zbtb16 gene variant in rodent models by Kábelová, Adéla, Malínská, Hana, Marková, Irena, Hüttl, Martina, Liška, František, Chylíková, Blanka, Šeda, Ondřej

“…Quercetin is a promising phytochemical in treating abnormalities associated with metabolic syndrome (MetS). This study aimed to explore the morphometric,…”
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The effect of dicarbonyl stress on the development of kidney dysfunction in metabolic syndrome - a transcriptomic and proteomic approach by Markova, Irena, Hüttl, Martina, Oliyarnyk, Olena, Kacerova, Tereza, Haluzik, Martin, Kacer, Petr, Seda, Ondrej, Malinska, Hana

“…Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and…”
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The Beneficial Additive Effect of Silymarin in Metformin Therapy of Liver Steatosis in a Pre-Diabetic Model by Hüttl, Martina, Markova, Irena, Miklankova, Denisa, Zapletalova, Iveta, Poruba, Martin, Racova, Zuzana, Vecera, Rostislav, Malinska, Hana

“…The combination of plant-derived compounds with anti-diabetic agents to manage hepatic steatosis closely associated with diabetes mellitus may be a new…”
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The Effect of Ovariectomy and Estradiol Substitution on the Metabolic Parameters and Transcriptomic Profile of Adipose Tissue in a Prediabetic Model by Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Šedová, Lucie, Šeda, Ondřej, Malínská, Hana

“…Menopause brings about profound physiological changes, including the acceleration of insulin resistance and other abnormalities, in which adipose tissue can…”
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Nutrigenetic Interaction of Spontaneously Hypertensive Rat Chromosome 20 Segment and High-Sucrose Diet Sensitizes to Metabolic Syndrome by Šeda, Ondřej, Junková, Kristýna, Malinska, Hana, Kábelová, Adéla, Hüttl, Martina, Krupková, Michaela, Markova, Irena, Liška, František, Šedová, Lucie

“…Several corresponding regions of human and mammalian genomes have been shown to affect sensitivity to the manifestation of metabolic syndrome via nutrigenetic…”
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Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat by Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Malínská, Hana, Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Mušálková, Dita, Stránecký, Viktor, Kmoch, Stanislav, Sticová, Eva, Vrbacký, Marek, Mráček, Tomáš, Pravenec, Michal

“…Recently, we have identified a recessive mutation, an abnormal coat appearance in the BXH6 strain, a member of the HXB/BXH set of recombinant inbred (RI)…”
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Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation by Junková, Kristýna, Mirchi, Lukáš F, Chylíková, Blanka, Janků, Michaela, Šilhavý, Jan, Hüttl, Martina, Marková, Irena, Miklánková, Denisa, Včelák, Josef, Malínská, Hana, Pravenec, Michal, Šeda, Ondřej, Liška, František

“…Metabolic syndrome (MetS) is an important cause of worldwide morbidity and mortality. Its complex pathogenesis includes, on the one hand, sedentary lifestyle…”
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Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia by Malinska, Hana, Ph.D, Hüttl, Martina, Ph.D, Oliyarnyk, Olena, Ph.D, Bratova, Miriam, M.Sc, Kazdova, Ludmila, Ph.D

“…Abstract Objective The metabolic health effects of conjugated linoleic acid (CLA), which is one of the principal polyunsaturated fatty acids, are controversial…”
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The Different Insulin-Sensitising and Anti-Inflammatory Effects of Palmitoleic Acid and Oleic Acid in a Prediabetes Model by Miklankova, Denisa, Markova, Irena, Hüttl, Martina, Stankova, Barbora, Malinska, Hana

“…Introduction. Monounsaturated fatty acids (MUFA) are understood to have therapeutic and preventive effects on chronic complications associated with type 2…”
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Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model by Hüttl, Martina, Markova, Irena, Miklánková, Denisa, Zapletalova, Iveta, Kujal, Petr, Šilhavý, Jan, Pravenec, Michal, Malinska, Hana

“…Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we…”
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