Search Results - "HÖPFNER, Michael"

Immunomodulatory properties of HDAC6 inhibitors in cancer diseases: New chances for sophisticated drug design and treatment optimization by Biersack, Bernhard, Nitzsche, Bianca, Höpfner, Michael

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Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents by Nitzsche, Bianca, Höpfner, Michael, Biersack, Bernhard

“…A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in cancer diseases due to its cooperative activity with the…”
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Editorial: Advances in molecular targeted therapies of urologic cancers by Nitzsche, Bianca, Höpfner, Michael

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The shunt problem: control of functional shunting in normal and tumour vasculature by Pries, Axel R, Höpfner, Michael, le Noble, Ferdinand, Dewhirst, Mark W, Secomb, Timothy W

“…This Opinion article discusses how aberrant vascular remodelling might lead to tumour hypoxia. What controls this process, and could this be reversed — or…”
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Abundant Nitrate and Nitric Acid Aerosol in the Upper Troposphere and Lower Stratosphere by Yu, Pengfei, Lian, Siying, Zhu, Yunqian, Toon, Owen B., Höpfner, Michael, Borrmann, Stephan

“…The tropospheric and stratospheric nitrate aerosol is simulated by a sectional aerosol model coupled to the Community Earth System Model. The simulated nitrate…”
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Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their ( p -Cymene)dichloridoruthenium(II) Complexes by Oberhuber, Natalie, Ghosh, Hindole, Nitzsche, Bianca, Dandawate, Prasad, Höpfner, Michael, Schobert, Rainer, Biersack, Bernhard

“…New -alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their ( -cymene)Ru(II) piano-stool complexes were…”
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Anticancer Activity and Mechanisms of Action of New Chimeric EGFR/HDAC-Inhibitors by Goehringer, Nils, Biersack, Bernhard, Peng, Yayi, Schobert, Rainer, Herling, Marco, Ma, Andi, Nitzsche, Bianca, Höpfner, Michael

“…New chimeric inhibitors targeting the epidermal growth factor (EGFR) and histone deacetylases (HDACs) were synthesized and tested for antineoplastic efficiency…”
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Three-dimensional distribution of a major desert dust outbreak over East Asia in March 2008 derived from IASI satellite observations by Cuesta, Juan, Eremenko, Maxim, Flamant, Cyrille, Dufour, Gaëlle, Laurent, Benoît, Bergametti, Gilles, Höpfner, Michael, Orphal, Johannes, Zhou, Daniel

“…We describe the daily evolution of the three-dimensional (3D) structure of a major dust outbreak initiated by an extratropical cyclone over East Asia in early…”
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Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer by Bär, Sofia Isolde, Dittmer, Alexandra, Nitzsche, Bianca, Ter-Avetisyan, Gohar, Fähling, Michael, Klefenz, Adrian, Kaps, Leonard, Biersack, Bernhard, Schobert, Rainer, Höpfner, Michael

“…Broxbam, also known as N-hydroxy-4-{1-methoxy-4-[4'-(3'-bromo-4',5'-dimethoxyphenyl)-oxazol-5'-yl]-2-phenoxy} butanamide, is a novel chimeric inhibitor that…”
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Monsoon circulations and tropical heterogeneous chlorine chemistry in the stratosphere by Solomon, Susan, Kinnison, Doug, Garcia, Rolando R., Bandoro, Justin, Mills, Michael, Wilka, Catherine, Neely, Ryan R., Schmidt, Anja, Barnes, John E., Vernier, Jean‐Paul, Höpfner, Michael

“…Model simulations presented in this paper suggest that transport processes associated with the summer monsoons bring increased abundances of hydrochloric acid…”
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Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer by Michael Hopfner Detlef Schuppan Hans Scherubl

“…Growth factors and their corresponding receptors are commonly overexpressed and/or dysregulated in many cancers including hepatocellular cancer （HCC）. Clinical…”
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Remotely Sensed Carbonyl Sulfide Constrains Model Estimates of Amazon Primary Productivity by Stinecipher, James R., Cameron‐Smith, Philip, Kuai, Le, Glatthor, Norbert, Höpfner, Michael, Baker, Ian, Beer, Christian, Bowman, Kevin, Lee, Meemong, Miller, Scot M., Parazoo, Nicholas, Campbell, J. Elliott

“…Understanding the magnitude of tropical gross primary production (GPP) is critical for carbon cycle modeling and climate projections, but this quantity is…”
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Structural adaptation and heterogeneity of normal and tumor microvascular networks by Pries, Axel R, Cornelissen, Annemiek J M, Sloot, Anoek A, Hinkeldey, Marlene, Dreher, Matthew R, Höpfner, Michael, Dewhirst, Mark W, Secomb, Timothy W

“…Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment…”
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Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure⁻Activity Relations of New Inhibitors of HDAC and/or Tubulin Function by Schmitt, Florian, Gosch, Lisa Chiara, Dittmer, Alexandra, Rothemund, Matthias, Mueller, Thomas, Schobert, Rainer, Biersack, Bernhard, Volkamer, Andrea, Höpfner, Michael

“…New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages of…”
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Retrieval of Water Vapour Profiles from GLORIA Nadir Observations by König, Nils, Wetzel, Gerald, Höpfner, Michael, Friedl-Vallon, Felix, Johansson, Sören, Kleinert, Anne, Schneider, Matthias, Ertl, Benjamin, Ungermann, Jörn

“…We present the first analysis of water vapour profiles derived from nadir measurements by the infrared imaging Fourier transform spectrometer GLORIA (Gimballed…”
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MIPAS observations of volcanic sulfate aerosol and sulfur dioxide in the stratosphere by Günther, Annika, Höpfner, Michael, Sinnhuber, Björn-Martin, Griessbach, Sabine, Deshler, Terry, von Clarmann, Thomas, Stiller, Gabriele

“…Volcanic eruptions can increase the stratospheric sulfur loading by orders of magnitude above the background level and are the most important source of…”
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Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer by Kuzyniak, Weronika, Schmidt, Jacob, Glac, Wojciech, Berkholz, Janine, Steinemann, Gustav, Hoffmann, Björn, Ermilov, Eugeny A, Gürek, Ayşe Gül, Ahsen, Vefa, Nitzsche, Bianca, Höpfner, Michael

“…Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal…”
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New 3-Aryl-2-(2-thienyl)acrylonitriles with High Activity Against Hepatoma Cells by Schaller, Eva, Ma, Andi, Gosch, Lisa Chiara, Klefenz, Adrian, Schaller, David, Goehringer, Nils, Kaps, Leonard, Schuppan, Detlef, Volkamer, Andrea, Schobert, Rainer, Biersack, Bernhard, Nitzsche, Bianca, Höpfner, Michael

“…New 2-(thien-2-yl)-acrylonitriles with putative kinase inhibitory activity were prepared and tested for their antineoplastic efficacy in hepatoma models. Four…”
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Animacroxam, a Novel Dual-Mode Compound Targeting Histone Deacetylases and Cytoskeletal Integrity of Testicular Germ Cell Cancer Cells by Steinemann, Gustav, Dittmer, Alexandra, Kuzyniak, Weronika, Hoffmann, Björn, Schrader, Mark, Schobert, Rainer, Biersack, Bernhard, Nitzsche, Bianca, Höpfner, Michael

“…Novel approaches for the medical treatment of advanced solid tumors, including testicular germ cell tumors (TGCT), are desperately needed. Especially, TGCT…”
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First Detection of a Brief Mesoscale Elevated Stratopause in Very Early Winter by García‐Comas, Maya, Funke, Bernd, López‐Puertas, Manuel, González‐Galindo, Francisco, Kiefer, Michael, Höpfner, Michael

“…Elevated stratopauses are typically associated with prolonged disturbed conditions in the Northern Hemisphere polar winter. The Michelson Interferometer for…”
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