Search Results - "HÄUSLER, Sebastian"

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity by Häusler, Sebastian F. M., Montalbán del Barrio, Itsaso, Strohschein, Jenny, Anoop Chandran, P., Engel, Jörg B., Hönig, Arnd, Ossadnik, Monika, Horn, Evi, Fischer, Birgitt, Krockenberger, Mathias, Heuer, Stefan, Seida, Ahmed Adel, Junker, Markus, Kneitz, Hermann, Kloor, Doris, Klotz, Karl-Norbert, Dietl, Johannes, Wischhusen, Jörg

“…The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine that inhibits T and NK cell responses via the A 2A adenosine receptor…”
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Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape by Montalbán del Barrio, Itsaso, Penski, Cornelia, Schlahsa, Laura, Stein, Roland G., Diessner, Joachim, Wöckel, Achim, Dietl, Johannes, Lutz, Manfred B., Mittelbronn, Michel, Wischhusen, Jörg, Häusler, Sebastian F. M.

“…BackgroundOvarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby…”
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Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study by Fill Malfertheiner, Sara, Brandstetter, Susanne, Roth, Samra, Harner, Susanne, Buntrock-Döpke, Heike, Toncheva, Antoaneta A., Borchers, Natascha, Gruber, Rudolf, Ambrosch, Andreas, Kabesch, Michael, Häusler, Sebastian

“…Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the…”
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Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D by Krockenberger, Mathias, Dombrowski, Yvonne, Weidler, Claudia, Ossadnik, Monika, Honig, Arnd, Hausler, Sebastian, Voigt, Heike, Becker, Jurgen C, Leng, Lin, Steinle, Alexander, Weller, Michael, Bucala, Richard, Dietl, Johannes, Wischhusen, Jorg

“…The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor cell proliferation, migration, and metastasis; promotes tumor…”
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Extraperitoneal Approach During Peritonectomy in the Right Upper Quadrant for Peritoneal Metastases from Ovarian Malignancies by Acs, Miklos, Leebmann, Hubert, Häusler, Sebastian, Harter, Philipp, Piso, Pompiliu

“…To present the extraperitoneal approach for the removal of peritoneal metastases in the right upper abdomen in patients with ovarian cancer and to evaluate…”
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CD33(+) /HLA-DR(neg) and CD33(+) /HLA-DR(+/-) Cells: Rare Populations in the Human Decidua with Characteristics of MDSC by Bartmann, Catharina, Junker, Markus, Segerer, Sabine E, Häusler, Sebastian F, Krockenberger, Mathias, Kämmerer, Ulrike

“…Human pregnancy needs a remarkable local immune tolerance toward the conceptus. Myeloid-derived suppressor cells (MDSC) are important players promoting cancer…”
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Cognate Nonlytic Interactions between CD8 + T Cells and Breast Cancer Cells Induce Cancer Stem Cell-like Properties by Stein, Roland G, Ebert, Stefan, Schlahsa, Laura, Scholz, Claus J, Braun, Matthias, Hauck, Petra, Horn, Evi, Monoranu, Camelia-Maria, Thiemann, Vincent J, Wustrow, Michael P, Häusler, Sebastian F, Montalbán Del Barrio, Itsaso, Stüber, Tanja N, Wölfl, Matthias, Dietl, Johannes, Rosenwald, Andreas, Diessner, Joachim E, Wöckel, Achim, Wischhusen, Jörg

“…Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even…”
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Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion by Häusler, Sebastian Fm, Del Barrio, Itsaso Montalbán, Diessner, Joachim, Stein, Roland G, Strohschein, Jenny, Hönig, Arnd, Dietl, Johannes, Wischhusen, Jörg

“…The ectonucleotidases CD39 and CD73 degrade ATP to adenosine which inhibits immune responses via the A2A adenosine receptor (ADORA2A) on T and NK cells. The…”
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Macrophage migration inhibitory factor expression in cervical cancer by Krockenberger, Mathias, Engel, Jörg B, Kolb, Julia, Dombrowsky, Yvonne, Häusler, Sebastian F. M, Kohrenhagen, Nico, Dietl, Johannes, Wischhusen, Jörg, Honig, Arnd

“…Purpose The glycoprotein macrophage migration inhibitory factor (MIF) is a cytokine that has been shown to promote tumor progression and tumor immune escape in…”
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Do Patients with Luminal A Breast Cancer Profit from Adjuvant Systemic Therapy? A Retrospective Multicenter Study by Diessner, Joachim, Wischnewsky, Manfred, Blettner, Maria, Häusler, Sebastian, Janni, Wolfgang, Kreienberg, Rolf, Stein, Roland, Stüber, Tanja, Schwentner, Lukas, Bartmann, Catharina, Wöckel, Achim

“…Luminal A breast cancers respond well to anti-hormonal therapy (HT), are associated with a generally favorable prognosis and constitute the majority of breast…”
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Effects of lobaplatin as a single agent and in combination with TRAIL on the growth of triple-negative p53-mutated breast cancers in vitro by Engel, Jörg B, Martens, Theresa, Hahne, Jens C, Häusler, Sebastian F.M, Krockenberger, Mathias, Segerer, Sabine, Djakovic, Antonia, Meyer, Susanne, Dietl, Johannes, Wischhusen, Jörg, Honig, Arnd

“…Lobaplatin as a single agent and in combination with tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is investigated in in-vitro models of…”
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A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity by Häusler, Sebastian F.M., Ossadnik, Monika, Horn, Evi, Heuer, Stefan, Dietl, Johannes, Wischhusen, Jörg

“…Extracellular adenosine exerts powerful paracrine effects on immune cells. Thus, adenosine signaling has to be strictly regulated. This is achieved by its…”
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Evaluation of Sentinel Lymph Node Biopsy and Axillary Lymph Node Dissection for Breast Cancer Treatment Concepts - a Retrospective Study of 1,214 Breast Cancer Patients by Stein, Roland G., Fricker, Roland, Rink, Thomas, Fitz, Hartmut, Blasius, Sebastian, Diessner, Joachim, Häusler, Sebastian F.M., Stüber, Tanja N., Andreas, Victoria, Wöckel, Achim, Müller, Thomas

“…Background: Most breast cancer patients require lumpectomy with axillary sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). The ACOSOG…”
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Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11β-hydroxysteroid dehydrogenases in multiple sclerosis: Implications for lesion pathogenesis by Heidbrink, Claudia, Häusler, Sebastian F.M, Buttmann, Mathias, Ossadnik, Monika, Strik, Herwig M, Keller, Andreas, Buck, Dorothea, Verbraak, Evert, van Meurs, Marjan, Krockenberger, Mathias, Mehling, Matthias, Mittelbronn, Michel, Laman, Jon D, Wiendl, Heinz, Wischhusen, Jörg

“…Abstract Relapses during multiple sclerosis (MS) are treated by administration of exogenous corticosteroids. However, little is known about the bioavailability…”
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Immunoselection of Breast and Ovarian Cancer Cells with Trastuzumab and Natural Killer Cells: Selective Escape of CD44high/CD24low/HER2low Breast Cancer Stem Cells by REIM, Florian, DOMBROWSKI, Yvonne, BECKER, Jürgen C, HÖNIG, Arnd, WISCHHUSEN, Jörg, RITTER, Cathrin, BUTTMANN, Mathias, HÄUSLER, Sebastian, OSSADNIK, Monika, KROCKENBERGER, Mathias, BEIER, Dagmar, BEIER, Christoph P, DIETL, Johannes

“…Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors…”
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CD33+/HLA-DRneg and CD33+/HLA-DR+/− Cells: Rare Populations in the Human Decidua with Characteristics of MDSC by Bartmann, Catharina, Junker, Markus, Segerer, Sabine E., Häusler, Sebastian F., Krockenberger, Mathias, Kämmerer, Ulrike

“…Problem Human pregnancy needs a remarkable local immune tolerance toward the conceptus. Myeloid‐derived suppressor cells (MDSC) are important players promoting…”
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Successful containment of Covid‐19 outbreak in a large maternity and perinatal center while continuing clinical service by Kabesch, Michael, Roth, Samra, Brandstetter, Susanne, Häusler, Sebastian, Juraschko, Eva, Weigl, Marco, Wellmann, Sven, Lang, Thomas, Schmidt, Barbara, Salzberger, Bernd, Ambrosch, Andreas, Kalaycı, Ömer

“…With increasing number of SARS‐CoV‐2 infections and COVID‐19 patients to be taken care of by the health system, more and more health workers become affected by…”
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Micro-ribonucleic acids and extracellular vesicles repertoire in the spent culture media is altered in women undergoing In Vitro Fertilization by Abu-Halima, Masood, Häusler, Sebastian, Backes, Christina, Fehlmann, Tobias, Staib, Claudia, Nestel, Sigrun, Nazarenko, Irina, Meese, Eckart, Keller, Andreas

“…MicroRNAs (miRNAs) are class of small RNA molecules with major impact on gene regulation. We analyzed the potential of miRNAs secreted from pre-implantation…”
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Parents’ intention to get vaccinated and to have their child vaccinated against COVID-19: cross-sectional analyses using data from the KUNO-Kids health study by Brandstetter, Susanne, Böhmer, Merle M., Pawellek, Maja, Seelbach-Göbel, Birgit, Melter, Michael, Kabesch, Michael, Apfelbacher, Christian

“…A COVID-19 vaccine can be an important key for mitigating the spread of the pandemic, provided that it is accepted by a sufficient proportion of the…”
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Malignant Struma Ovarii Τreated With Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) by Acs, Miklos, Häusler, Sebastian, Lighvani, Hamid-Reza, Zustin, Jozef, Piso, Pompiliu

“…Malignant struma ovarii is an extremely rare tumor entity among ovarian tumors. In the presence of ascites and peritoneal metastases, the preoperative…”
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