Search Results - "HÄGERSTRAND, D"

Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity by Guo, Min, van Vliet, Marjolein, Zhao, Jian, de Ståhl, Teresita Díaz, Lindström, Mikael S, Cheng, Huaitao, Heller, Susanne, Nistér, Monica, Hägerstrand, Daniel

“…Abstract Background Glioblastomas display a high level of intratumoral heterogeneity with regard to both genetic and histological features. Within single…”
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IκBε deficiency accelerates disease development in chronic lymphocytic leukemia by Bordini, Jessica, Lenzi, Chiara, Frenquelli, Michela, Morabito, Alessia, Pseftogas, Athanasios, Belloni, Daniela, Mansouri, Larry, Tsiolas, George, Perotta, Eleonora, Ranghetti, Pamela, Gandini, Francesca, Genova, Francesca, Hägerstrand, Daniel, Gavriilidis, Georgios, Keisaris, Sofoklis, Pechlivanis, Nikolaos, Davi, Frederic, Kay, Neil E., Langerak, Anton W., Pospisilova, Sarka, Scarfò, Lydia, Makris, Antonios, Psomopoulos, Fotis E., Stamatopoulos, Kostas, Rosenquist, Richard, Campanella, Alessandro, Ghia, Paolo

“…The NFKBIE gene, which encodes the NF-κB inhibitor IκBε, is mutated in 3–7% of patients with chronic lymphocytic leukemia (CLL). The most recurrent alteration…”
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TRAF2 is an NF-κB-activating oncogene in epithelial cancers by Shen, R R, Zhou, A Y, Kim, E, O'Connell, J T, Hagerstrand, D, Beroukhim, R, Hahn, W C

“…Aberrant nuclear factor (NF)-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in…”
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Characterization of an imatinib-sensitive subset of high-grade human glioma cultures by HÄGERSTRAND, D, HESSELAGER, G, ACHTERBERG, S, WICKENBERG BOLIN, U, KOWANETZ, M, KASTEMAR, M, HELDIN, C.-H, ISAKSSON, A, NISTER, M, ÖSTMAN, A

“…High-grade gliomas, including glioblastomas, are malignant brain tumors for which improved treatment is urgently needed. Genetic studies have demonstrated the…”
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The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia by Hägerstrand, Daniel, Oder, Blaž, Cortese, Diego, Qu, Ying, Binzer-Panchal, Amrei, Österholm, Cecilia, Del Peso Santos, Teresa, Rabbani, Leily, Asl, Hassan Foroughi, Skaftason, Aron, Ljungström, Viktor, Lundholm, August, Koutroumani, Maria, Haider, Zahra, Jylhä, Cecilia, Mollstedt, John, Mansouri, Larry, Plevova, Karla, Agathangelidis, Andreas, Scarfò, Lydia, Armand, Marine, Muggen, Alice F., Kay, Neil E., Shanafelt, Tait, Rossi, Davide, Orre, Lukas M., Pospisilova, Sarka, Barylyuk, Konstantin, Davi, Frederic, Vesterlund, Mattias, Langerak, Anton W., Lehtiö, Janne, Ghia, Paolo, Stamatopoulos, Kostas, Sutton, Lesley-Ann, Rosenquist, Richard

“…SF3B1 mutations are recurrent in chronic lymphocytic leukemia (CLL), particularly enriched in clinically aggressive stereotyped subset #2. To investigate their…”
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The association between Annexin A2 and epithelial cell adhesion molecule in breast cancer cells by Al‐Qahtani, Saad Misfer, Gadalla, Salah Eldin, Guo, Min, Ericsson, Christer, Hägerstrand, Daniel, Nistér, Monica

“…Background The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane and glycosylated protein, which is overexpressed in many neoplasms. However,…”
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PO-336 Identification of SOX2 and SFRP2 as opposing regulators of glioblastoma heterogeneous subtypes by Guo, M, Nister, M, Hagerstrand, D

“…IntroductionGlioblastomas display high levels of intra-tumour heterogeneity. It has recently been shown that individual glioblastomas may contain an…”
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PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status by Roodakker, Kenney R, Elsir, Tamador, Edqvist, Per-Henrik D, Hägerstrand, Daniel, Carlson, Joseph, Lysiak, Malgorzata, Henriksson, Roger, Pontén, Fredrik, Rosell, Johan, Söderkvist, Peter, Stupp, Roger, Tchougounova, Elena, Nistér, Monica, Malmström, Annika, Smits, Anja

“…PROX1 is a transcription factor with an essential role in embryonic development and determination of cell fate. In addition, PROX1 has been ascribed…”
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Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 by Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars

“…[This corrects the article DOI: 10.18632/oncotarget.19404.]…”
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Erratum: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 (Oncotarget (2017) 8 (84671-84684) DOI: 10.18632/oncotarget.19404) by Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A. J., Edwards, Steven, Hägerstrand, D., Berglund, U. W., Helleday, T., Bräutigam, L.

“…This article has been corrected: The Funding information has been updated. The complete Funding list is shown below: FUNDING This work was supported by the…”
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P1282: DISEASE‐SPECIFIC U1 SPLICEOSOMAL RNA MUTATIONS IN MATURE B‐CELL NEOPLASMS by Nadeu, F., Shuai, S., Clot, G., Hilton, L. K., Diaz‐Navarro, A., Martín, S., Royo, R., Baumann, T., Kulis, M., López‐Oreja, I., Cossio, M., Lu, J., Ljungström, V., Young, E., Plevova, K., Knisbacher, B. A., Lin, Z., Hahn, C. K., Bousquets, P., Alcoceba, M., González, M., Colado, E., Aymerich, M., Terol, M. J., Rivas‐Delgado, A., Enjuanes, A., Ruiz‐Gaspà, S., Chatzikonstantinou, T., Hägerstrand, D., Jylhä, C., Skaftason, A., Mansouri, L., Stranska, K., Doubek, M., Gastel‐Mol, E. J., Davis, Z., Walewska, R., Scarfò, L., Trentin, L., Visentin, A., Parikh, S. A., Rabe, K. G., Moia, R., Armand, M., Rossi, D., Davi, F., Gaidano, G., Kay, N. E., Shanafelt, T., Ghia, P., Oscier, D., Langerak, A. W., Beà, S., López‐Guillermo, A., Neuberg, D., Wu, C. J., Getz, G., Pospisilova, S., Stamatopoulos, K., Rosenquist, R., Huber, W., Zenz, T., Colomer, D., Martín‐Subero, J. I., Delgado, J., Morin, R. D., Stein, L. D., Puente, X. S., Campo, E.

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A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer by Sjöberg, Elin, Meyrath, Max, Milde, Laura, Herrera, Mercedes, Lövrot, John, Hägerstrand, Daniel, Frings, Oliver, Bartish, Margarita, Rolny, Charlotte, Sonnhammer, Erik, Chevigné, Andy, Augsten, Martin, Östman, Arne

“…Fibroblasts expressing the orphan chemokine CXCL14 have been previously shown to associate with poor breast cancer prognosis and promote cancer growth. This…”
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Astrocytes enhance glioblastoma growth by Mega, Alessandro, Hartmark Nilsen, Mette, Leiss, Lina Wik, Tobin, Nicholas P., Miletic, Hrvoje, Sleire, Linda, Strell, Carina, Nelander, Sven, Krona, Cecilia, Hägerstrand, Daniel, Enger, Per Ø., Nistér, Monica, Östman, Arne

“…Glioblastoma (GBM) is a deadly disease with a need for deeper understanding and new therapeutic approaches. The microenvironment of glioblastoma has previously…”
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SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma by Guo, Min, Goudarzi, Kaveh M., Abedi, Shiva, Pieber, Melanie, Sjöberg, Elin, Behnan, Jinan, Zhang, Xing-Mei, Harris, Robert A., Bartek, Jiri, Lindström, Mikael S., Nistér, Monica, Hägerstrand, Daniel

“…Intratumoral heterogeneity is a characteristic of glioblastomas that contain an intermixture of cell populations displaying different glioblastoma subtype gene…”
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Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes by Keller, Maureen, Blom, Magdalena, Conze, Lei Liu, Guo, Min, Hägerstrand, Daniel, Aspenström, Pontus

“…Glioblastoma is a highly aggressive brain tumor with poor patient prognosis. Treatment outcomes remain limited, partly due to intratumoral heterogeneity and…”
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Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype by Goudarzi, Kaveh M, Espinoza, Jaime A, Guo, Min, Bartek, Jiri, Nistér, Monica, Lindström, Mikael S, Hägerstrand, Daniel

“…The homeodomain transcription factor PROX1 has been linked to several cancer types, including gliomas, but its functions remain to be further elucidated. Here…”
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Correction to: SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma by Guo, Min, Goudarzi, Kaveh M., Abedi, Shiva, Pieber, Melanie, Sjöberg, Elin, Behnan, Jinan, Zhang, Xing-Mei, Harris, Robert A., Bartek, Jiri, Lindström, Mikael S., Nistér, Monica, Hägerstrand, Daniel

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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 by Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars

“…Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis. Cancer cells are characterized by a specific redox environment that…”
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Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile by Hägerstrand, Daniel, He, Xiaobing, Bradic Lindh, Maja, Hoefs, Saskia, Hesselager, Göran, Östman, Arne, Nistér, Monica

“…Putative cancer stem cells have been identified in glioblastomas and are associated with radio- and chemo-resistance. Further knowledge about these cells is…”
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TRAF2 is an NF-[kappa]B-activating oncogene in epithelial cancers by Shen, R R, Zhou, A Y, Kim, E, O'connell, J T, Hagerstrand, D, Beroukhim, R, Hahn, W C

“…Aberrant nuclear factor (NF)-kB activation is frequently observed in human cancers. Genome characterization efforts have identied genetic alterations in…”
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