Search Results - "Gyorgy, Bence"

1,6-Hexanediol Is Inducing Homologous Recombination by Releasing BLM from Assemblysomes in Drosophila melanogaster by Gombás, Bence György, Villányi, Zoltán

“…We recently demonstrated that 1,6-hexanediol inhibits the formation of assemblysomes. These membraneless cell organelles have important roles in…”
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High levels of AAV vector integration into CRISPR-induced DNA breaks by Hanlon, Killian S., Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Volak, Adrienn, Spirig, Stefan E., Muller, Alissa, Sousa, Alexander A., Tsai, Shengdar Q., Bengtsson, Niclas E., Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S., Corey, David P., Aryee, Martin J., Joung, J. Keith, Breakefield, Xandra O., Maguire, Casey A., György, Bence

“…Adeno-associated virus (AAV) vectors have shown promising results in preclinical models, but the genomic consequences of transduction with AAV vectors encoding…”
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Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate by György, Bence, Meijer, Elise J., Ivanchenko, Maryna V., Tenneson, Kelly, Emond, Frederick, Hanlon, Killian S., Indzhykulian, Artur A., Volak, Adrienn, Karavitaki, K. Domenica, Tamvakologos, Panos I., Vezina, Mark, Berezovskii, Vladimir K., Born, Richard T., O’Brien, Maureen, Lafond, Jean-François, Arsenijevic, Yvan, Kenna, Margaret A., Maguire, Casey A., Corey, David P.

“…Hereditary hearing loss often results from mutation of genes expressed by cochlear hair cells. Gene addition using AAV vectors has shown some efficacy in mouse…”
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A base editor for correcting deafness by György, Bence

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Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection by Eimer, William A., Vijaya Kumar, Deepak Kumar, Navalpur Shanmugam, Nanda Kumar, Rodriguez, Alex S., Mitchell, Teryn, Washicosky, Kevin J., György, Bence, Breakefield, Xandra O., Tanzi, Rudolph E., Moir, Robert D.

“…Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer’s disease (AD) pathology. We recently reported Aβ is an innate…”
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Emerging role of extracellular vesicles in inflammatory diseases by Buzas, Edit I., György, Bence, Nagy, György, Falus, András, Gay, Steffen

“…Key Points The evolutionarily conserved release of extracellular vesicles (EVs), including exosomes, microvesicles (microparticles) and apoptotic vesicles, is…”
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TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells by Pan, Bifeng, Akyuz, Nurunisa, Liu, Xiao-Ping, Asai, Yukako, Nist-Lund, Carl, Kurima, Kiyoto, Derfler, Bruce H., György, Bence, Limapichat, Walrati, Walujkar, Sanket, Wimalasena, Lahiru N., Sotomayor, Marcos, Corey, David P., Holt, Jeffrey R.

“…The proteins that form the permeation pathway of mechanosensory transduction channels in inner-ear hair cells have not been definitively identified. Genetic,…”
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Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss by György, Bence, Nist-Lund, Carl, Pan, Bifeng, Asai, Yukako, Karavitaki, K. Domenica, Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Solanes, Paola, Spataro, Sofia, Schneider, Bernard L., Joung, J. Keith, Géléoc, Gwenaëlle S. G., Holt, Jeffrey R., Corey, David P.

“…Since most dominant human mutations are single nucleotide substitutions 1 , 2 , we explored gene editing strategies to disrupt dominant mutations efficiently…”
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Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts by Pásztói, Mária, Nagy, György, Géher, Pál, Lakatos, Tamás, Tóth, Kálmán, Wellinger, Károly, Pócza, Péter, György, Bence, Holub, Marianna C, Kittel, Agnes, Pálóczy, Krisztina, Mazán, Mercédesz, Nyirkos, Péter, Falus, András, Buzas, Edit I

“…Similar to matrix metalloproteinases, glycosidases also play a major role in cartilage degradation. Carbohydrate cleavage products, generated by these latter…”
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Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions by György, Bence, Hung, Michelle E, Breakefield, Xandra O, Leonard, Joshua N

“…This review provides an updated perspective on rapidly proliferating efforts to harness extracellular vesicles (EVs) for therapeutic applications. We summarize…”
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Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV by György, Bence, Sage, Cyrille, Indzhykulian, Artur A., Scheffer, Deborah I., Brisson, Alain R., Tan, Sisareuth, Wu, Xudong, Volak, Adrienn, Mu, Dakai, Tamvakologos, Panos I., Li, Yaqiao, Fitzpatrick, Zachary, Ericsson, Maria, Breakefield, Xandra O., Corey, David P., Maguire, Casey A.

“…Adeno-associated virus (AAV) is a safe and effective vector for gene therapy for retinal disorders. Gene therapy for hearing disorders is not as advanced, in…”
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Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection by Wassmer, Sarah J., Carvalho, Livia S., György, Bence, Vandenberghe, Luk H., Maguire, Casey A.

“…Widespread gene transfer to the retina is challenging as it requires vector systems to overcome physical and biochemical barriers to enter and diffuse…”
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Genome and base editing for genetic hearing loss by Niggemann, Philipp, György, Bence, Chen, Zheng-Yi

“…Genome editing opens up a new frontier in developing personalized therapeutic solutions. With the unprecedented advance in the discovery and engineering of…”
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Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno‐associated virus vectors by György, Bence, Maguire, Casey A.

“…Gene therapy, the ability to treat a disease at the level of nucleic acid, has journeyed from science fiction, to hard lessons learned from early clinical…”
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Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo by György, Bence, Fitzpatrick, Zachary, Crommentuijn, Matheus H.W, Mu, Dakai, Maguire, Casey A

“…Abstract Recently adeno-associated virus (AAV) became the first clinically approved gene therapy product in the western world. To develop AAV for future…”
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Effect of prolactin on normal and keratoconus human corneal stromal fibroblasts in vitro by Anders, Philipp, Song, Xuefei, György, Bence, Szentmary, Nora, Seitz, Berthold, Gatzioufas, Zisis

“…To examine the effect of prolactin (PRL) on human corneal stromal fibroblasts (CSFs), derived from healthy individuals and from keratoconus (KC) patients, in…”
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Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis by György, Bence, Tóthfalusi, László, Nagy, György, Pásztói, Mária, Géher, Pál, Lörinc, Zsolt, Polgár, Anna, Rojkovich, Bernadett, Ujfalussy, Ilona, Poór, Gyula, Pócza, Péter, Wiener, Zoltán, Misják, Petra, Koncz, Agnes, Falus, András, Buzás, Edit I

“…Although natural autoantibodies make up the majority of circulating immunoglobulins and are also present in high numbers in therapeutically used intravenous…”
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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease by György, Bence, Lööv, Camilla, Zaborowski, Mikołaj P., Takeda, Shuko, Kleinstiver, Benjamin P., Commins, Caitlin, Kastanenka, Ksenia, Mu, Dakai, Volak, Adrienn, Giedraitis, Vilmantas, Lannfelt, Lars, Maguire, Casey A., Joung, J. Keith, Hyman, Bradley T., Breakefield, Xandra O., Ingelsson, Martin

“…The APPswe (Swedish) mutation in the amyloid precursor protein (APP) gene causes dominantly inherited Alzheimer’s disease (AD) as a result of increased…”
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Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles by György, Bence, Szabó, Tamás G., Pásztói, Mária, Pál, Zsuzsanna, Misják, Petra, Aradi, Borbála, László, Valéria, Pállinger, Éva, Pap, Erna, Kittel, Ágnes, Nagy, György, Falus, András, Buzás, Edit I.

“…Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a…”
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Citrullination: A posttranslational modification in health and disease by György, Bence, Tóth, Erzsébet, Tarcsa, Edit, Falus, András, Buzás, Edit I.

“…Posttranslational modifications are chemical changes to proteins that take place after synthesis. One such modification, peptidylarginine to peptidylcitrulline…”
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