Synthesis, structure and properties of complex compounds of cobalt, nickel, copper and zinc with 2-formylpyridine semicarbazone
2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML 2 X 2 · n H 2 O (M=Co, Ni, Cu, Zn; X = Cl, NO 3 , ClO 4 ; L = NC 5 H 4 -CH=N-NH-C(O)-NH 2 ; n = 0, 1) and CuLX 2 · n H 2 O (X = Cl, Br,...
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| Published in: | Russian journal of general chemistry Vol. 79; no. 7; pp. 1499 - 1503 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Dordrecht
SP MAIK Nauka/Interperiodica
01-07-2009
|
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | 2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML
2
X
2
·
n
H
2
O (M=Co, Ni, Cu, Zn; X = Cl, NO
3
, ClO
4
; L = NC
5
H
4
-CH=N-NH-C(O)-NH
2
;
n
= 0, 1) and CuLX
2
·
n
H
2
O (X = Cl, Br, NO
3
;
n
= 0−0.5). Complex CuL(NO
3
)
2
has polynuclear, CuLX
2
·0.5H
2
O (X = Cl, Br), binuclear, and other compounds, mononuclear structures. Azomethine
L
behaves in them as tridental N,N,O-ligand. Thermolysis of these complexes proceeds through such stages as dehydration (80–95°C), deactivation (145–155°C) and complete theral degradation (170–590°C). Complexes CuLX
2
·
n
H
2
O (X = Cl, NO
3
;
n
= 0−0.5) were established to inhibit in vitro the growth and reproduction of 100% of cancer cells of human mieloid leukaemia HL-60 at 10
−4
M concentration. At 10
−5
M concentration they inhibit only 10% of cells, and at 10
−6
M concentration they do not possess anticancer activity. |
|---|---|
| ISSN: | 1070-3632 1608-3350 |
| DOI: | 10.1134/S1070363209070160 |