Search Results - "Gylling, H."

The role of serum non-cholesterol sterols as surrogate markers of absolute cholesterol synthesis and absorption by Miettinen, T.A, Gylling, H, Nissinen, M.J

“…Abstract Aims To study the whole-body cholesterol metabolism in man, cholesterol synthesis and absorption need to be measured. Because of the complicated…”
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Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase by Simonen, P., Li, S., Chua, N. K., Lampi, A.‐M., Piironen, V., Lommi, J., Sinisalo, J., Brown, A. J., Ikonen, E., Gylling, H.

“…Background We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of…”
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Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass by Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., Laakso, M., Gylling, H., Patti, M. E., Auwerx, J., Pihlajamäki, Jussi

“…Background Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we…”
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Desmosterol accumulation in users of amiodarone by Simonen, P., Lehtonen, J., Lampi, A. ‐M., Piironen, V., Stenman, U. ‐H., Kupari, M., Gylling, H.

“…Background Amiodarone is an effective and widely used antiarrhythmic drug with many possible adverse effects including hypercholesterolaemia and…”
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Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment by Miettinen, T. A., Gylling, H.

“…Background  Serum contains noncholesterol sterols, which are reliable markers of cholesterol metabolism, but their presence and importance in different…”
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Progress and prospective of plant sterol and plant stanol research: Report of the Maastricht meeting by Plat, J, Mackay, D, Baumgartner, S, Clifton, P.M, Gylling, H, Jones, P.J.H

“…Abstract Abundant evidence over past decades shows that foods with added plant sterols and plant stanols lower serum LDL cholesterol concentrations. However,…”
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Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study by Kolehmainen, M, Salopuro, T, Schwab, U.S, Kekalainen, J, Kallio, P, Laaksonen, D.E, Pulkkinen, L, Lindi, V.I, Sivenius, K, Mager, U

“…Objective: Lifestyle and genetic factors interact in the development of obesity and the metabolic syndrome. The molecular mechanisms underlying the beneficial…”
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Pandemic influenza: human rights, ethics and duty to treat by PAHLMAN, I., TOHMO, H., GYLLING, H.

“…The 2009 influenza A/H1N1 pandemic seems to be only moderately severe. In the future, a pandemic influenza with high lethality, such as the Spanish influenza…”
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Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety by Laitinen, K., Isolauri, E., Kaipiainen, L., Gylling, H., Miettinen, T.A.

“…Clinical safety of consuming plant stanol ester spreads during pregnancy and lactation, the impact on maternal and infant serum and breast-milk cholesterol and…”
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Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia by Gylling, H

“…Cardiovascular diseases are the principal causes of mortality in middle-aged people and in older people. Coronary heart disease (CHD) is the most common of the…”
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Genetic Risk Score Does Not Predict the Outcome of Obesity Surgery by Käkelä, P., Jääskeläinen, T., Torpström, J., Ilves, I., Venesmaa, S., Pääkkönen, M., Gylling, H., Paajanen, H., Uusitupa, M., Pihlajamäki, J.

“…Background We evaluated the benefit of using combined genetic risk score (GRS) of known single nucleotide polymorphisms (SNPs) for body mass index (BMI) and…”
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Downregulation of genes involved in NFκB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study by de Mello, V. D. F, Kolehmainen, M, Pulkkinen, L, Schwab, U, Mager, U, Laaksonen, D. E, Niskanen, L, Gylling, H, Atalay, M, Rauramaa, R, Uusitupa, M

“…Aims/hypothesis The transcription factor nuclear factor-kappa-B (NFκB) is implicated in inflammatory responses, obesity and the metabolic syndrome, while…”
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Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study by Miettinen, Tatu A, Gylling, Helena, Strandberg, Timo, Sarna, Seppo

“…Abstract Objectives: To investigate whether baseline serum cholestanol:cholesterol ratio, which is negatively related to cholesterol synthesis, could predict…”
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Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet by HALLIKAINEN, M. A, SARKKINEN, E. S, GYLLING, H, ERKKILÄ, A. T, UUSITUPA, M. I. J

“…To investigate cholesterol-lowering effects of stanol ester (STAEST) and sterol ester (STEEST)-enriched margarines as part of a low-fat diet. According to a…”
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Evidence based medicine guidelines: a solution to rationing or politics disguised as science? by Saarni, S I, Gylling, H A

“…“Evidence based medicine” (EBM) is often seen as a scientific tool for quality improvement, even though its application requires the combination of scientific…”
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Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors by Gylling, A.H.S., Nieminen, T.T., Abdel-Rahman, W.M., Nuorva, K., Juhola, M., Joensuu, E.I., Järvinen, H.J., Mecklin, J.-P., Aarnio, M., Peltomäki, P.T.

“…Hereditary non-polyposis colorectal carcinoma (Lynch syndrome) is among the most common hereditary cancers in man and a model of cancers arising through…”
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Noncholesterol Sterols and Cholesterol Lowering by Long-Term Simvastatin Treatment in Coronary Patients: Relation to Basal Serum Cholestanol by Miettinen, T A, Strandberg, T E, Gylling, H

“…Coronary patients with low baseline ratios of serum cholestanol and plant sterols to cholesterol (indicating low cholesterol absorption) but not those with…”
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Serum high sensitivity C-reactive protein and cognitive function in elderly women by Komulainen, Pirjo, Lakka, Timo A., Kivipelto, Miia, Hassinen, Maija, Penttilä, Ilkka M., Helkala, Eeva-Liisa, Gylling, Helena, Nissinen, Aulikki, Rauramaa, Rainer

“…Background: inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and…”
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Cholesterol Metabolism Altered and FGF21 Levels High After Pediatric Liver Transplantation Despite Normal Serum Lipids by Kosola, S., Lampela, H., Gylling, H., Jalanko, H., Nissinen, M. J., Lauronen, J., Mäkisalo, H., Vaaralahti, K., Miettinen, T. A., Raivio, T., Pakarinen, M. P.

“…Liver transplantation (LT) predisposes to metabolic derangements and increases the risk for cardiovascular disease. We conducted a national cross‐sectional…”
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Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men by Nissinen, M.J, Miettinen, T.E, Gylling, H, Miettinen, T.A

“…Abstract Background and aims We hypothesized that (I) certain features in cholesterol metabolism at baseline could predict a response to statins, (II) good and…”
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