Search Results - "Gyenesei, Attila"
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Transcriptome profiling of the murine testis during the first wave of spermatogenesis
Published in PloS one (17-04-2013)“…Correct gene expression patterns form the basis for male germ cell differentiation and male fertility. Although previous studies have elucidated the importance…”
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The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children
Published in International journal of molecular sciences (13-07-2021)“…Type 1 Diabetes (T1D) results from autoimmune destruction of insulin producing pancreatic ß-cells. This disease, with a peak incidence in childhood, causes the…”
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On the Boundary of Exploratory Genomics and Translation in Sequential Glioblastoma
Published in International journal of molecular sciences (01-07-2024)“…OMICS methods brought significant advancements to the understanding of tumor cell biology, which transformed the treatment and prognosis of several cancers…”
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Editorial: Copy Number Variation in Rare Disorders
Published in Frontiers in genetics (05-04-2022)Get full text
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Physical Activity as a Preventive Lifestyle Intervention Acts Through Specific Exosomal miRNA Species—Evidence From Human Short- and Long-Term Pilot Studies
Published in Frontiers in physiology (02-08-2021)“…Exercise initiates systemic adaptation to promote health and prevent various lifestyle-related chronic diseases. Emerging evidence suggests that circulating…”
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Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis
Published in Journal of headache and pain (06-10-2021)“…Background Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze the…”
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miRNA-Seq Tissue Diagnostic Signature: A Novel Model for NSCLC Subtyping
Published in International journal of molecular sciences (01-09-2023)“…Non-small cell lung cancer (NSCLC) encompasses distinct histopathological subtypes, namely adenocarcinoma (AC) and squamous cell lung carcinoma (SCC), which…”
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Importance and application of WES in fetal genetic diagnostics: Identification of novel ASPM mutation in a fetus with microcephaly
Published in Molecular genetics and metabolism reports (01-03-2024)“…Prenatal whole exome sequencing (WES) approaches can provide genetic diagnosis with rapid turnaround time and high diagnostic rate when conventional tests are…”
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Missing Heritability in Albinism: Deep Characterization of a Hungarian Albinism Cohort Raises the Possibility of the Digenic Genetic Background of the Disease
Published in International journal of molecular sciences (01-01-2024)“…Albinism is characterized by a variable degree of hypopigmentation affecting the skin and the hair, and causing ophthalmologic abnormalities. Its…”
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Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization
Published in International journal of molecular sciences (22-04-2020)“…A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain neuropeptides such as tachykinins or calcitonin gene-related peptide…”
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PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism
Published in International journal of molecular sciences (14-02-2022)“…Pituitary adenylate cyclase-activating polypeptide (PACAP) is a broadly expressed neuropeptide which has diverse effects in both the peripheral and central…”
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PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study
Published in International journal of molecular sciences (12-03-2021)“…Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a…”
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Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress
Published in Journal of headache and pain (02-09-2022)“…Background Migraine is a primary headache with genetic susceptibility, but the pathophysiological mechanisms are poorly understood, and it remains an unmet…”
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The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival
Published in Chromosoma (01-09-2021)“…The Drosophila Trithorax group (TrxG) protein ASH1 remains associated with mitotic chromatin through mechanisms that are poorly understood. ASH1 dimethylates…”
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Linear ubiquitination by LUBEL has a role in Drosophila heat stress response
Published in EMBO reports (01-11-2016)“…The HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with HOIL‐1L and SHARPIN in mammals. Here, we provide the first evidence of…”
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Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains
Published in International journal of molecular sciences (21-10-2020)“…Somatostatin is an important mood and pain-regulating neuropeptide, which exerts analgesic, anti-inflammatory, and antidepressant effects via its Gi…”
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NGS-Based Application for Routine Non-Invasive Pre-Implantation Genetic Assessment in IVF
Published in International journal of molecular sciences (28-02-2021)“…Although non-invasive pre-implantation genetic testing for aneuploidy (NIPGT-A) is potentially appropriate to assess chromosomal ploidy of the embryo,…”
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Evaluation of Transcriptomic Regulations behind Metabolic Syndrome in Obese and Lean Subjects
Published in International journal of molecular sciences (20-02-2020)“…Multiple mechanisms have been suggested to confer to the pathophysiology of metabolic syndrome (MetS), however despite great interest from the scientific…”
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Clinicopathological analysis of diffuse large B-cell lymphoma using molecular biomarkers: a retrospective analysis from 7 Hungarian centers
Published in Frontiers in oncology (08-09-2023)“…Background The clinical and genetic heterogeneity of diffuse large B-cell lymphoma (DLBCL) presents distinct challenges in predicting response to therapy and…”
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