Search Results - "Gye Young Park"

Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases by Park, Gye Young, Christman, John W

“…Inducible cyclooxygenase (COX-2) and its metabolites have diverse and potent biological actions that are important for both physiological and disease states of…”
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A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction by Han, Jeongmin, Kim, Iktae, Park, Jae-Hyun, Yun, Ji-Hye, Joo, Keehyoung, Kim, Taehee, Park, Gye-Young, Ryu, Kyoung-Seok, Ko, Yoon-Joo, Mizutani, Kenji, Park, Sam-Young, Seong, Rho Hyun, Lee, Jooyoung, Suh, Jeong-Yong, Lee, Weontae

“…Human SNF5 and BAF155 constitute the core subunit of multi-protein SWI/SNF chromatin-remodeling complexes that are required for ATP-dependent nucleosome…”
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Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression by Deng, Jing, Wang, Xuerong, Qian, Feng, Vogel, Stephen, Xiao, Lei, Ranjan, Ravi, Park, Hyesuk, Karpurapu, Manjula, Ye, Richard D, Park, Gye Young, Christman, John W

“…Reactive oxygen species (ROS) generated by NADPH oxidase are generally known to be proinflammatory, and it seems to be counterintuitive that ROS play a…”
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Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma by Lee, Yong Gyu, Jeong, Jong Jin, Nyenhuis, Sharmilee, Berdyshev, Evgeny, Chung, Sangwoon, Ranjan, Ravi, Karpurapu, Manjula, Deng, Jing, Qian, Feng, Kelly, Elizabeth A B, Jarjour, Nizar N, Ackerman, Steven J, Natarajan, Viswanathan, Christman, John W, Park, Gye Young

“…Although alveolar macrophages (AMs) from patients with asthma are known to be functionally different from those of healthy individuals, the mechanism by which…”
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Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness by Grozdanovic, Milica, Laffey, Kimberly G., Abdelkarim, Hazem, Hitchinson, Ben, Harijith, Anantha, Moon, Hyung-Geon, Park, Gye Young, Rousslang, Lee K., Masterson, Joanne C., Furuta, Glenn T., Tarasova, Nadya I., Gaponenko, Vadim, Ackerman, Steven J.

“…Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date,…”
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Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling by Kim, Young-Mee, Krantz, Sarah, Jambusaria, Ankit, Toth, Peter T., Moon, Hyung-Geun, Gunarathna, Isuru, Park, Gye Young, Rehman, Jalees

“…Endothelial barrier integrity is ensured by the stability of the adherens junction (AJ) complexes comprised of vascular endothelial (VE)-cadherin as well as…”
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Colony‐stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma by Moon, Hyung‐Geun, Kim, Seung‐jae, Lee, Myoung Kyu, Kang, Homan, Choi, Hak Soo, Harijith, Anantha, Ren, Jinhong, Natarajan, Viswanathan, Christman, John W., Ackerman, Steven J., Park, Gye Young

“…Background A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1‐CSF1R pathway has a…”
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Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization by Moon, Hyung-Geun, Kim, Seung-jae, Jeong, Jong Jin, Han, Seon-Sook, Jarjour, Nizar N., Lee, Hyun, Abboud-Werner, Sherry L., Chung, Sangwoon, Choi, Hak Soo, Natarajan, Viswanathan, Ackerman, Steven J., Christman, John W., Park, Gye Young

“…Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway…”
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Body Weight and Allergic Asthma: A Narrative Review by Imayama, Ikuyo, Eccles, Jacob D, Ascoli, Christian, Kudlaty, Elizabeth, Park, Gye Young

“…Obesity is a known risk factor for asthma development, progression, and exacerbation. Nevertheless, the underlying pathophysiological mechanisms explaining how…”
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Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation by GYE YOUNG PARK, YONG GYU LEE, JING DENG, RANJAN, Ravi, LEI XIAO, ARI JAFFE, H, CORBRIDGE, Susan J, KELLY, Elizabeth A. B, JARJOUR, Nizar N, CHUN, Jerold, PRESTWICH, Glenn D, KAFFE, Eleanna, BERDYSHEV, Evgeny, NINOU, Ioanna, AIDINIS, Vassilis, MORRIS, Andrew J, SMYTH, Susan S, ACKERMAN, Steven J, NATARAJAN, Viswanathan, CHRISTMAN, John W, SHARMILEE NYENHUIS, JIAN DU, PANFENG FU, GORSHKOVA, Irina A, YONGCHAO LI, SANGWOON CHUNG, KARPURAPU, Manjula

“…Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors…”
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Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation by Kim, Ji Young, Stevens, Patrick, Karpurapu, Manjula, Lee, Hyunwook, Englert, Joshua A, Yan, Pearlly, Lee, Tae Jin, Pabla, Navjot, Pietrzak, Maciej, Park, Gye Young, Christman, John W, Chung, Sangwoon

“…Asthma is phenotypically heterogeneous with several distinctive pathological mechanistic pathways. Previous studies indicate that neutrophilic asthma has a…”
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The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation by Qian, Feng, Deng, Jing, Lee, Yong Gyu, Zhu, Jimmy, Karpurapu, Manjula, Chung, Sangwoon, Zheng, Jun-Nian, Xiao, Lei, Park, Gye Young, Christman, John W

“…The transcription factor PU.1 is involved in regulation of macrophage differentiation and maturation. However, the role of PU.1 in alternatively activated…”
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Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway by Cheng, Dong-sheng, Han, Wei, Chen, Sabrina M, Sherrill, Taylor P, Chont, Melissa, Park, Gye-Young, Sheller, James R, Polosukhin, Vasiliy V, Christman, John W, Yull, Fiona E, Blackwell, Timothy S

“…Although airway epithelial cells provide important barrier and host defense functions, a crucial role for these cells in development of acute lung inflammation…”
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FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype by Chung, Sangwoon, Lee, Tae Jin, Reader, Brenda F, Kim, Ji Young, Lee, Yong Gyu, Park, Gye Young, Karpurapu, Manjula, Ballinger, Megan N, Qian, Feng, Rusu, Luiza, Chung, Hae Young, Unterman, Terry G, Croce, Carlo M, Christman, John W

“…Inflammatory monocyte and tissue macrophages influence the initiation, progression, and resolution of type 2 immune responses, and alveolar macrophages are the…”
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Polyunsaturated lysophosphatidic acid as a potential asthma biomarker by Ackerman, Steven J, Park, Gye Young, Christman, John W, Nyenhuis, Sharmilee, Berdyshev, Evgeny, Natarajan, Viswanathan

“…Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA…”
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E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury by Bachmaier, Kurt, Toya, Sophie, Gao, Xiaopei, Triantafillou, Thomas, Garrean, Sean, Park, Gye Young, Frey, Randall S, Vogel, Stephen, Minshall, Richard, Christman, John W, Tiruppathi, Chinnaswamy, Malik, Asrar B

“…The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected…”
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Polyunsaturated Lysophosphatidic Acid As a Potential Asthma Biomarker by Ackerman, Steven J., PhD, Nyenhuis, Sharmilee M., MD, FAAAAI, Park, Gye Young, MD, Christman, John W., MD, Natarajan, Viswanathan, PhD, Berdyshev, Evgeny, PhD

“…Rationale Lysophosphatidic acid (LPA), a lipid mediator present in biological fluids, is generated by the enzymatic action of autotaxin (ATX) that hydrolyzes…”
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NIK Is Involved in Nucleosomal Regulation by Enhancing Histone H3 Phosphorylation by IKKα by Park, Gye Young, Wang, Xuerong, Hu, Ningning, Pedchenko, Tetyana V., Blackwell, Timothy S., Christman, John W.

“…The exact physiological role of NF-κB-inducing kinase (NIK) in the NF-κB activation pathway has not been defined, although it is an upstream kinase of IKKα…”
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Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages by Joo, Myungsoo, Wright, Jeffrey G, Hu, Ning Ning, Sadikot, Ruxana T, Park, Gye Young, Blackwell, Timothy S, Christman, John W

“…Expression of cyclooxygenase-2 (COX-2) is associated with the pathogenesis of inflammation and various cancers, including lung cancer. Yin Yang 1 (YY1) is a…”
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In vitro maturation of oocytes derived from the brown bear (Ursus arctos) by Yin, X.J.(Sunchon National Univ., JeonNam (Korea R.)), Lee, H.S, Choi, E.G, Yu, X.F, Park, G.Y, Bae, I, Yang, C.J, Oh, D.H, Kim, N.H, Kong, I.K

“…This study was conducted to determine whether meiotic maturation could be induced in ovarian oocytes from the American brown bear (Ursus arctos), a model for…”
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