Search Results - "Gyõrffy, Balázs"

Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer by Győrffy, Balázs

“…Background and Purpose Survival rate of patients with lung cancer has increased by over 60% in the recent two decades. With longer survival, the identification…”
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Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer by Győrffy, Balázs

“…[Display omitted] Extensive research is directed to uncover new biomarkers capable to stratify breast cancer patients into clinically relevant cohorts…”
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Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer by Győrffy, Balázs

“…Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high demand for reliable prognostic…”
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Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation by Lánczky, András, Győrffy, Balázs

“…Background: Survival analysis is a cornerstone of medical research, enabling the assessment of clinical outcomes for disease progression and treatment…”
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Pancancer survival analysis of cancer hallmark genes by Nagy, Ádám, Munkácsy, Gyöngyi, Győrffy, Balázs

“…Cancer hallmark genes are responsible for the most essential phenotypic characteristics of malignant transformation and progression. In this study, our aim was…”
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TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues by Bartha, Áron, Győrffy, Balázs

“…Genes showing higher expression in either tumor or metastatic tissues can help in better understanding tumor formation and can serve as biomarkers of…”
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Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets by Nagy, Ádám, Lánczky, András, Menyhárt, Otília, Győrffy, Balázs

“…Multiple studies suggested using different miRNAs as biomarkers for prognosis of hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression…”
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Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma by Menyhárt, Otília, Nagy, Ádám, Győrffy, Balázs

“…Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC) are abundant, but their generalizability is unexplored. We cross-validated markers…”
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Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer by Győrffy, Balázs, Surowiak, Pawel, Budczies, Jan, Lánczky, András

“…In the last decade, optimized treatment for non-small cell lung cancer had lead to improved prognosis, but the overall survival is still very short. To further…”
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MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction by Menyhart, Otília, Weltz, Boglárka, Gyorffy, Balázs

“…Scientists from nearly all disciplines face the problem of simultaneously evaluating many hypotheses. Conducting multiple comparisons increases the likelihood…”
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ROCplot.org: Validating predictive biomarkers of chemotherapy/hormonal therapy/anti‐HER2 therapy using transcriptomic data of 3,104 breast cancer patients by Fekete, János T., Győrffy, Balázs

“…Systemic therapy of breast cancer can include chemotherapy, hormonal therapy and targeted therapy. Prognostic biomarkers are able to predict survival and…”
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Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches by Menyhárt, Otília, Gyorffy, Balázs

“…Medulloblastoma (MB) is the most common malignant childhood tumor of the brain. Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy…”
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Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors by Győrffy, Balázs

“…Identifying genes with prognostic significance that can act as biomarkers in solid tumors can help stratify patients and uncover novel therapy targets. Here,…”
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DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer by Müller, Dalma, Győrffy, Balázs

“…DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA methylation were suggested to be useful biomarkers for diagnosis, and for…”
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muTarget: A platform linking gene expression changes and mutation status in solid tumors by Nagy, Ádám, Győrffy, Balázs

“…Large oncology repositories have paired genomic and transcriptomic data for all patients. We used these data to perform two independent analyses: to identify…”
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Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis by Menyhárt, Otília, Győrffy, Balázs

“…•Single-level data analysis produced by high-throughput technologies is limited by showing only a narrow window of cellular functions.•Data integration across…”
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Survival analysis in breast cancer using proteomic data from four independent datasets by Ősz, Ágnes, Lánczky, András, Győrffy, Balázs

“…Breast cancer clinical treatment selection is based on the immunohistochemical determination of four protein biomarkers: ESR1, PGR, HER2, and MKI67. Our aim…”
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Transcriptomic datasets of cancer patients treated with immune-checkpoint inhibitors: a systematic review by Kovács, Szonja Anna, Gyorffy, Balázs

“…The availability of immune-checkpoint inhibitors (ICI) in the last decade has resulted in a paradigm shift in certain areas of oncology. Patients can be…”
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Different mutations in SARS-CoV-2 associate with severe and mild outcome by Nagy, Ádám, Pongor, Sándor, Győrffy, Balázs

“…•A database of 4566 SARS-CoV-2 virus sequences and follow-up data was established•Mutations were mapped to amino acid changes for 3,733 non-silent…”
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Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients by Gyorffy, Balázs, Lánczky, András, Szállási, Zoltán

“…The validation of prognostic biomarkers in large independent patient cohorts is a major bottleneck in ovarian cancer research. We implemented an online tool to…”
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