Search Results - "Gwosch, Eva"
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The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress
Published in PloS one (13-08-2019)“…DNA replication stress is a major source of genomic instability and is closely linked to tumor formation and progression. Poly(ADP-ribose)polymerases1/2…”
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Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells
Published in Nucleic acids research (01-12-2016)“…Genotoxic stress activates PARP1, resulting in the post-translational modification of proteins with poly(ADP-ribose) (PAR). We genetically deleted PARP1 in one…”
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DEK oncoprotein participates in heterochromatin replication via SUMO-dependent nuclear bodies
Published in Journal of cell science (01-12-2023)“…The correct inheritance of chromatin structure is key for maintaining genome function and cell identity and preventing cellular transformation. DEK, a…”
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Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation
Published in Angewandte Chemie International Edition (05-09-2016)“…Poly(ADP‐ribos)ylation (PARylation) is an important posttranslational protein modification, and is involved in major cellular processes such as gene regulation…”
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Zelluläre Mikroskopie der Poly(ADP-Ribos)ylierung von Proteinen in Echtzeit
Published in Angewandte Chemie (05-09-2016)“…Poly(ADP‐Ribos)ylierung (PARylierung) ist eine wichtige posttranslationale Proteinmodifikation, die in grundlegende zelluläre Prozesse wie Genregulation und…”
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