Search Results - "Gwinn, Ryder P."

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex by Mich, John K., Graybuck, Lucas T., Hess, Erik E., Mahoney, Joseph T., Kojima, Yoshiko, Ding, Yi, Somasundaram, Saroja, Miller, Jeremy A., Kalmbach, Brian E., Radaelli, Cristina, Gore, Bryan B., Weed, Natalie, Omstead, Victoria, Bishaw, Yemeserach, Shapovalova, Nadiya V., Martinez, Refugio A., Fong, Olivia, Yao, Shenqin, Mortrud, Marty, Chong, Peter, Loftus, Luke, Bertagnolli, Darren, Goldy, Jeff, Casper, Tamara, Dee, Nick, Opitz-Araya, Ximena, Cetin, Ali, Smith, Kimberly A., Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew L., Ojemann, Jeffrey G., Keene, C. Dirk, Silbergeld, Daniel L., Sunkin, Susan M., Gradinaru, Viviana, Horwitz, Gregory D., Zeng, Hongkui, Tasic, Bosiljka, Lein, Ed S., Ting, Jonathan T., Levi, Boaz P.

“…Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin…”
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Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex by Seeman, Stephanie C, Campagnola, Luke, Davoudian, Pasha A, Hoggarth, Alex, Hage, Travis A, Bosma-Moody, Alice, Baker, Christopher A, Lee, Jung Hoon, Mihalas, Stefan, Teeter, Corinne, Ko, Andrew L, Ojemann, Jeffrey G, Gwinn, Ryder P, Silbergeld, Daniel L, Cobbs, Charles, Phillips, John, Lein, Ed, Murphy, Gabe, Koch, Christof, Zeng, Hongkui, Jarsky, Tim

“…Generating a comprehensive description of cortical networks requires a large-scale, systematic approach. To that end, we have begun a pipeline project using…”
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Morpho-electric diversity of human hippocampal CA1 pyramidal neurons by Mertens, Eline J., Leibner, Yoni, Pie, Jean, Galakhova, Anna A., Waleboer, Femke, Meijer, Julia, Heistek, Tim S., Wilbers, René, Heyer, Djai, Goriounova, Natalia A., Idema, Sander, Verhoog, Matthijs B., Kalmbach, Brian E., Lee, Brian R., Gwinn, Ryder P., Lein, Ed S., Aronica, Eleonora, Ting, Jonathan, Mansvelder, Huibert D., Segev, Idan, de Kock, Christiaan P.J.

“…Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known…”
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A scalable and modular automated pipeline for stitching of large electron microscopy datasets by Mahalingam, Gayathri, Torres, Russel, Kapner, Daniel, Trautman, Eric T, Fliss, Tim, Seshamani, Shamishtaa, Perlman, Eric, Young, Rob, Kinn, Samuel, Buchanan, JoAnn, Takeno, Marc M, Yin, Wenjing, Bumbarger, Daniel J, Gwinn, Ryder P, Nyhus, Julie, Lein, Ed, Smith, Steven J, Reid, R Clay, Khairy, Khaled A, Saalfeld, Stephan, Collman, Forrest, Macarico da Costa, Nuno

“…Serial-section electron microscopy (ssEM) is the method of choice for studying macroscopic biological samples at extremely high resolution in three dimensions…”
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Conserved cell types with divergent features in human versus mouse cortex by Hodge, Rebecca D., Bakken, Trygve E., Miller, Jeremy A., Smith, Kimberly A., Barkan, Eliza R., Graybuck, Lucas T., Close, Jennie L., Long, Brian, Johansen, Nelson, Penn, Osnat, Yao, Zizhen, Eggermont, Jeroen, Höllt, Thomas, Levi, Boaz P., Shehata, Soraya I., Aevermann, Brian, Beller, Allison, Bertagnolli, Darren, Brouner, Krissy, Casper, Tamara, Cobbs, Charles, Dalley, Rachel, Dee, Nick, Ding, Song-Lin, Ellenbogen, Richard G., Fong, Olivia, Garren, Emma, Goldy, Jeff, Gwinn, Ryder P., Hirschstein, Daniel, Keene, C. Dirk, Keshk, Mohamed, Ko, Andrew L., Lathia, Kanan, Mahfouz, Ahmed, Maltzer, Zoe, McGraw, Medea, Nguyen, Thuc Nghi, Nyhus, Julie, Ojemann, Jeffrey G., Oldre, Aaron, Parry, Sheana, Reynolds, Shannon, Rimorin, Christine, Shapovalova, Nadiya V., Somasundaram, Saroja, Szafer, Aaron, Thomsen, Elliot R., Tieu, Michael, Quon, Gerald, Scheuermann, Richard H., Yuste, Rafael, Sunkin, Susan M., Lelieveldt, Boudewijn, Feng, David, Ng, Lydia, Bernard, Amy, Hawrylycz, Michael, Phillips, John W., Tasic, Bosiljka, Zeng, Hongkui, Jones, Allan R., Koch, Christof, Lein, Ed S.

“…Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we…”
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How might tissue glucose influence responsive neurostimulation detection? by Wright, Kyla E., Kollmyer, Devon M., Warner, Nicole M., Haltiner, Alan M., Gwinn, Ryder P., Doherty, Michael J.

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Real‐world experience with direct brain‐responsive neurostimulation for focal onset seizures by Razavi, Babak, Rao, Vikram R., Lin, Christine, Bujarski, Krzysztof A., Patra, Sanjay E., Burdette, David E., Geller, Eric B., Brown, Mesha‐Gay M., Johnson, Emily A., Drees, Cornelia, Chang, Edward F., Greenwood, Janet E., Heck, Christianne N., Jobst, Barbara C., Gwinn, Ryder P., Warner, Nicole M., Halpern, Casey H.

“…Objective The RNS System is a direct brain‐responsive neurostimulation system that is US Food and Drug Administration–approved for adults with medically…”
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h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex by Kalmbach, Brian E., Buchin, Anatoly, Long, Brian, Close, Jennie, Nandi, Anirban, Miller, Jeremy A., Bakken, Trygve E., Hodge, Rebecca D., Chong, Peter, de Frates, Rebecca, Dai, Kael, Maltzer, Zoe, Nicovich, Philip R., Keene, C. Dirk, Silbergeld, Daniel L., Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew L., Ojemann, Jeffrey G., Koch, Christof, Anastassiou, Costas A., Lein, Ed S., Ting, Jonathan T.

“…Gene expression studies suggest that differential ion channel expression contributes to differences in rodent versus human neuronal physiology. We tested…”
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Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial by Heck, Christianne N., King‐Stephens, David, Massey, Andrew D., Nair, Dileep R., Jobst, Barbara C., Barkley, Gregory L., Salanova, Vicenta, Cole, Andrew J., Smith, Michael C., Gwinn, Ryder P., Skidmore, Christopher, Van Ness, Paul C., Bergey, Gregory K., Park, Yong D., Miller, Ian, Geller, Eric, Rutecki, Paul A., Zimmerman, Richard, Spencer, David C., Goldman, Alica, Edwards, Jonathan C., Leiphart, James W., Wharen, Robert E., Fessler, James, Fountain, Nathan B., Worrell, Gregory A., Gross, Robert E., Eisenschenk, Stephan, Duckrow, Robert B., Hirsch, Lawrence J., Bazil, Carl, O'Donovan, Cormac A., Sun, Felice T., Courtney, Tracy A., Seale, Cairn G., Morrell, Martha J.

“…Summary Objective To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency…”
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A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits by Ting, Jonathan T., Kalmbach, Brian, Chong, Peter, de Frates, Rebecca, Keene, C. Dirk, Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew L., Ojemann, Jeffrey G., Ellenbogen, Richard G., Koch, Christof, Lein, Ed

“…The powerful suite of available genetic tools is driving tremendous progress in understanding mouse brain cell types and circuits. However, the degree of…”
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Sudden unexpected death in epilepsy in patients treated with brain‐responsive neurostimulation by Devinsky, Orrin, Friedman, Daniel, Duckrow, Robert B, Fountain, Nathan B, Gwinn, Ryder P, Leiphart, James W, Murro, Anthony M, Van Ness, Paul C

“…Summary Objective To study the incidence and clinical features of sudden unexpected death in epilepsy (SUDEP) in patients treated with direct brain‐responsive…”
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Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation system by Hirsch, Lawrence J., Mirro, Emily A., Salanova, Vicenta, Witt, Thomas C., Drees, Cornelia N., Brown, Mesha‐Gay, Lee, Ricky W., Sadler, Toni L., Felton, Elizabeth A., Rutecki, Paul, Shin, Hae Won, Hadar, Eldad, Hegde, Manu, Rao, Vikram R., Mnatsakanyan, Lilit, Madhavan, Deepak S., Zakaria, Tarek J., Liu, Anli A., Heck, Christianne N., Greenwood, Janet E., Bigelow, Jeffrey K., Nair, Dileep R., Alexopoulos, Andreas V., Mackow, Michael, Edwards, Jonathan C., Sotudeh, Nadia, Kuzniecky, Ruben I., Gwinn, Ryder P., Doherty, Michael J., Geller, Eric B., Morrell, Martha J.

“…Objective To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) seizure onsets…”
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Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons by Kalmbach, Brian E., Hodge, Rebecca D., Jorstad, Nikolas L., Owen, Scott, de Frates, Rebecca, Yanny, Anna Marie, Dalley, Rachel, Mallory, Matt, Graybuck, Lucas T., Radaelli, Cristina, Keene, C. Dirk, Gwinn, Ryder P., Silbergeld, Daniel L., Cobbs, Charles, Ojemann, Jeffrey G., Ko, Andrew L., Patel, Anoop P., Ellenbogen, Richard G., Bakken, Trygve E., Daigle, Tanya L., Dee, Nick, Lee, Brian R., McGraw, Medea, Nicovich, Philip R., Smith, Kimberly, Sorensen, Staci A., Tasic, Bosiljka, Zeng, Hongkui, Koch, Christof, Lein, Ed S., Ting, Jonathan T.

“…In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric…”
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Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography by King‐Stephens, David, Mirro, Emily, Weber, Peter B., Laxer, Kenneth D., Van Ness, Paul C., Salanova, Vicenta, Spencer, David C., Heck, Christianne N., Goldman, Alica, Jobst, Barbara, Shields, Donald C., Bergey, Gregory K., Eisenschenk, Stephan, Worrell, Gregory A., Rossi, Marvin A., Gross, Robert E., Cole, Andrew J., Sperling, Michael R., Nair, Dileep R., Gwinn, Ryder P., Park, Yong D., Rutecki, Paul A., Fountain, Nathan B., Wharen, Robert E., Hirsch, Lawrence J., Miller, Ian O., Barkley, Gregory L., Edwards, Jonathan C., Geller, Eric B., Berg, Michel J., Sadler, Toni L., Sun, Felice T., Morrell, Martha J.

“…Summary Objective Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video–electroencephalography (EEG) monitoring with…”
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In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields by Richardson, Kristen A., Gluckman, Bruce J., Weinstein, Steven L., Glosch, Caryn E., Moon, Jessica B., Gwinn, Ryder P., Gale, Karen, Schiff, Steven J.

“…Purpose: Electric field stimulation can interact with brain activity in a subthreshold manner. Electric fields have been previously adaptively applied to…”
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Local spatial effect of 50 Hz cortical stimulation in humans by Gwinn, Ryder P., Spencer, Dennis D., Spencer, Susan S., Duckrow, Robert B., Vives, Kenneth, Wu, Kun, Tkeshelashvili, David, Zaveri, Hitten P.

“…Summary Purpose: Cortical stimulation to abort seizures is under human investigation. Ideal electrode placement and stimulating parameters are unknown with…”
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Does glucose influence multidien cycles of interictal and/or ictal activities? by Pappas, Alexa, Kubsad, Sanjay, Baud, Maxime O., Wright, Kyla E., Kollmyer, Devon M., Warner, Nicole M., Haltiner, Alan M., Gwinn, Ryder P., Doherty, Michael J.

“…•RNS Neuropace and Continuous glucose monitoring allows correlation of hourly seizure and glucose data.•Glucose does not appear to be a major influence on…”
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Introduction. Focused ultrasound by Lipsman, Nir, Elias, W Jeffrey, Gwinn, Ryder P, Pilitsis, Julie G

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Preoperative relative cerebral blood volume analysis in gliomas predicts survival and mitigates risk of biopsy sampling error by McCullough, Brendan J., Ader, Valerie, Aguedan, Brian, Feng, Xu, Susanto, Daniel, Benkers, Tara L., Henson, John W., Mayberg, Marc, Cobbs, Charles S., Gwinn, Ryder P., Monteith, Stephen J., Newell, David W., Delashaw, Johnny, Fouke, Sarah J., Rostad, Steven, Keogh, Bart P.

“…Appropriate management of adult gliomas requires an accurate histopathological diagnosis. However, the heterogeneity of gliomas can lead to misdiagnosis and…”
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Down syndrome associated moyamoya may worsen epilepsy control and can benefit from surgical revascularization by Garson, Sarah R, Monteith, Stephen J, Smith, Sheila D, Keogh, Bart P, Gwinn, Ryder P, Doherty, Michael J

“…Abstract Objectives To examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat…”
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