Search Results - "Gwinn, Dana M"

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint by Gwinn, Dana M., Shackelford, David B., Egan, Daniel F., Mihaylova, Maria M., Mery, Annabelle, Vasquez, Debbie S., Turk, Benjamin E., Shaw, Reuben J.

“…AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by…”
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy by Egan, Daniel F, Shackelford, David B, Mihaylova, Maria M, Gelino, Sara, Kohnz, Rebecca A, Mair, William, Vasquez, Debbie S, Joshi, Aashish, Gwinn, Dana M, Taylor, Rebecca, Asara, John M, Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J

“…Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and…”
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Raptor is phosphorylated by cdc2 during mitosis by Gwinn, Dana M, Asara, John M, Shaw, Reuben J

“…The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes…”
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Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities by Kelly, Marcus R, Kostyrko, Kaja, Han, Kyuho, Mooney, Nancie A, Jeng, Edwin E, Spees, Kaitlyn, Dinh, Phuong T, Abbott, Keene L, Gwinn, Dana M, Sweet-Cordero, E Alejandro, Bassik, Michael C, Jackson, Peter K

“…Activating mutations in RAS GTPases drive many cancers, but limited understanding of less-studied RAS interactors, and of the specific roles of different RAS…”
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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase by Gwinn, Dana M., Lee, Alex G., Briones-Martin-del-Campo, Marcela, Conn, Crystal S., Simpson, David R., Scott, Anna I., Le, Anthony, Cowan, Tina M., Ruggero, Davide, Sweet-Cordero, E. Alejandro

“…KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT…”
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Abstract B27: Kras alters expression of asparagine synthetase (Asns) in non-small cell lung cancer (NSCLC) and protects tumors during nutrient stress by Gwinn, Dana M., Sweet-Cordero, Alejandro

“…Abstract Kras is a small GTPase that functions in the transmission of extracellular mitogenic stimuli, and is one of the most frequently mutated genes in…”
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AMPK Control of mTOR Signaling and Growth by Gwinn, Dana M., Shaw, Reuben J.

“…The AMP-activated serine/threonine protein kinase (AMPK) is a sensor of cellular energy status found in all eukaryotes—that is, activated under conditions of…”
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