Viruses are a dominant driver of protein adaptation in mammals

Viruses are a dominant driver of protein adaptation in mammals

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interact...

Full description

Saved in:
Bibliographic Details
Published in:eLife Vol. 5
Main Authors: Enard, David, Cai, Le, Gwennap, Carina, Petrov, Dmitri A
Format: Journal Article
Language:English
Published: England eLife Sciences Publications Ltd 17-05-2016
eLife Sciences Publications, Ltd
Subjects:
Adaptation
Adaptation, Biological
adaptive evolution
Amino acid sequence
Animals
Computational and Systems Biology
Evolution & development
Evolution, Molecular
Genomes
Genomics
Genomics and Evolutionary Biology
Host-Pathogen Interactions
human evolution
Humans
Kinases
Mammals
Ontology
Proteins
Proteins - genetics
Proteomes
Signal transduction
Virology
Viruses
Viruses - genetics
computational biology
systems biology
viruses
evolutionary biology
mammals
human evolution
genomics
host/pathogen interactions
adaptive evolution
human
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins conserved in all sequenced mammalian genomes. We show that viruses (i) use the more evolutionarily constrained proteins within the cellular functions they interact with and that (ii) despite this high constraint, virus-interacting proteins account for a high proportion of all protein adaptation in humans and other mammals. Adaptation is elevated in virus-interacting proteins across all functional categories, including both immune and non-immune functions. We conservatively estimate that viruses have driven close to 30% of all adaptive amino acid changes in the part of the human proteome conserved within mammals. Our results suggest that viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.12469