Search Results - "Gwathmey, Judith K"

Autonomic and endocrine control of cardiovascular function by Gordan, Richard, Gwathmey, Judith K, Xie, Lai-Hua

“…The function of the heart is to contract and pump oxygenated blood to the body and deoxygenated blood to the lungs.To achieve this goal,a normal human heart…”
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Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease by Xie, Lai-Hua, Fefelova, Nadezhda, Pamarthi, Sri Harika, Gwathmey, Judith K

“…Ferroptosis has recently been demonstrated to be a novel regulated non-apoptotic cell death characterized by iron-dependence and the accumulation of lipid…”
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Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis by Fefelova, Nadezhda, Wongjaikam, Suwakon, Pamarthi, Sri Harika, Siri-Angkul, Natthaphat, Comollo, Thomas, Kumari, Anshu, Garg, Vivek, Ivessa, Andreas, Chattipakorn, Siriporn C., Chattipakorn, Nipon, Gwathmey, Judith K., Xie, Lai-Hua

“…Iron overload associated cardiac dysfunction remains a significant clinical challenge whose underlying mechanism(s) have yet to be defined. We aim to evaluate…”
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Calcium and Heart Failure: How Did We Get Here and Where Are We Going? by Siri-Angkul, Natthaphat, Dadfar, Behzad, Jaleel, Riya, Naushad, Jazna, Parambathazhath, Jaseela, Doye, Angelia, Xie, Lai-Hua, Gwathmey, Judith

“…The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing…”
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Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore by Gordan, Richard, Fefelova, Nadezhda, Gwathmey, Judith K, Xie, Lai-Hua

“…Iron (Fe) plays an essential role in many physiological processes. Hereditary hemochromatosis or frequent blood transfusions often cause iron overload (IO),…”
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Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure by Kawase, Yoshiaki, MD, Ly, Hung Q., MD, MSc, Prunier, Fabrice, MD, PhD, Lebeche, Djamel, PhD, Shi, Yanfen, MD, Jin, Hongwei, PhD, Hadri, Lahouaria, PhD, Yoneyama, Ryuichi, MD, PhD, Hoshino, Kozo, MD, Takewa, Yoshiaki, MD, PhD, Sakata, Susumu, PhD, Peluso, Richard, PhD, Zsebo, Krisztina, PhD, Gwathmey, Judith K., VMD, PhD, Tardif, Jean-Claude, MD, Tanguay, Jean-François, MD, Hajjar, Roger J., MD

“…Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure Yoshiaki Kawase, Hung Q. Ly,…”
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Targeting sarcoplasmic reticulum calcium ATPase by gene therapy by Gwathmey, Judith K, Yerevanian, Armen, Hajjar, Roger J

“…Although pharmacologic therapies have provided gains in reducing the mortality of heart failure, the rising incidence of the disease requires new approaches to…”
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Potential Roles of IP3 Receptors and Calcium in Programmed Cell Death and Implications in Cardiovascular Diseases by Piamsiri, Chanon, Fefelova, Nadezhda, Pamarthi, Sri Harika, Gwathmey, Judith K., Chattipakorn, Siriporn C., Chattipakorn, Nipon, Xie, Lai-Hua

“…Inositol 1,4,5-trisphosphate receptors (IP3Rs) play a crucial role in maintaining intracellular/cytosolic calcium ion (Ca2+i) homeostasis. The release of Ca2+…”
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Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology by Wen, Hairuo, Gwathmey, Judith K, Xie, Lai-Hua

“…Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely…”
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Ventricular Arrhythmias after Left Ventricular Assist Device Implantation by REFAAT, MARWAN, CHEMALY, ELIE, LEBECHE, DJAMEL, GWATHMEY, JUDITH K., HAJJAR, ROGER J.

“…Background: Left ventricular assist devices (LVADs) have been used as a bridge to cardiac transplantation and as destination therapy in patients with advanced…”
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PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury by Nagoshi, Tomohisa, Matsui, Takashi, Aoyama, Takuma, Leri, Annarosa, Anversa, Piero, Li, Ling, Ogawa, Wataru, del Monte, Federica, Gwathmey, Judith K, Grazette, Luanda, Hemmings, Brian A, Hemmings, Brian, Kass, David A, Champion, Hunter C, Rosenzweig, Anthony

“…Acute activation of the serine-threonine kinase Akt is cardioprotective and reduces both infarction and dysfunction after ischemia/reperfusion injury (IRI)…”
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Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes by Kitsy, Abderrazak, Carney, Skyla, Vivar, Juan C, Knight, Megan S, Pointer, Mildred A, Gwathmey, Judith K, Ghosh, Sujoy

“…The essential branched-chain amino acids (BCAA), leucine, valine and isoleucine, are traditionally associated with skeletal muscle growth and maintenance,…”
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Titin isoform switch in ischemic human heart disease by NEAGOE, Ciprian, KULKE, Michael, DEL MONTE, Federica, GWATHMEY, Judith K, DE TOMBE, Pieter P, HAJJAR, Roger J, LINKE, Wolfgang A

“…Ischemia-induced cardiomyopathy usually is accompanied by elevated left ventricular end-diastolic pressure, which follows from increased myocardial stiffness…”
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Targeting phospholamban by gene transfer in human heart failure by DEL MONTE, Federica, HARDING, Sian E, DEC, G. William, GWATHMEY, Judith K, HAJJAR, Roger J

“…Myocardial cells from failing human hearts are characterized by abnormal calcium handling, a negative force-frequency relationship, and decreased sarcoplasmic…”
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Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure by DEL MONTE, Federica, WILLIAMS, Eric, LEBECHE, Djemal, SCHMIDT, Ulrich, ROSENZWEIG, Anthony, GWATHMEY, Judith K, LEWANDOWSKI, E. Douglas, HAJJAR, Roger J

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Abrogation of Ventricular Arrhythmias in a Model of Ischemia and Reperfusion by Targeting Myocardial Calcium Cycling by del Monte, Federica, Lebeche, Djamel, Guerrero, J. Luis, Tsuji, Tsuyoshi, Doye, Angelia A., Gwathmey, Judith K., Hajjar, Roger J., Leaf, Alexander

“…Abnormal intracellular Ca2+ cycling plays an important role in cardiac dysfunction and ventricular arrhythmias in the setting of heart failure and transient…”
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Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a by DEL MONTE, F, HARDING, S. E, SCHMIDT, U, MATSUI, T, ZHAO BIN KANG, DEC, G. W, GWATHMEY, J. K, ROSENZWEIG, A, HAJJAR, R. J

“…Failing human myocardium is characterized by abnormal relaxation, a deficient sarcoplasmic reticulum (SR) Ca(2+) uptake, and a negative frequency response,…”
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Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates by Gwathmey, Judith K, Tsaioun, Katya, Hajjar, Roger J

“…Despite the FDA guidelines for studies to be performed to rule out potential cardiac toxicity, many drugs have nevertheless entered the market only to be later…”
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A Novel Mutant Cardiac Troponin C Disrupts Molecular Motions Critical for Calcium Binding Affinity and Cardiomyocyte Contractility by Lim, Chee Chew, Yang, Haijun, Yang, Mingfeng, Wang, Chien-Kao, Shi, Jianru, Berg, Eric A., Pimentel, David R., Gwathmey, Judith K., Hajjar, Roger J., Helmes, Michiel, Costello, Catherine E., Huo, Shuanghong, Liao, Ronglih

“…Troponin C (TnC) belongs to the superfamily of EF-hand (helix–loop–helix) Ca 2+-binding proteins and is an essential component of the regulatory thin filament…”
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Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c) by Dally, Saoussen, Bredoux, Raymonde, Corvazier, Elisabeth, Andersen, Jens P, Clausen, Johannes D, Dode, Leonard, Fanchaouy, Mohammed, Gelebart, Pascal, Monceau, Virginie, Del Monte, Frederica, Gwathmey, Judith K, Hajjar, Roger, Chaabane, Chiraz, Bobe, Régis, Raies, Aly, Enouf, Jocelyne

“…We recently documented the expression of a novel human mRNA variant encoding a yet uncharacterized SERCA [SR (sarcoplasmic reticulum)/ER (endoplasmic…”
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