Search Results - "Gwack, Yousang"

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum by Srikanth, Sonal, Woo, Jin Seok, Wu, Beibei, El-Sherbiny, Yasser M., Leung, Jennifer, Chupradit, Koollawat, Rice, Laura, Seo, Gil Ju, Calmettes, Guillaume, Ramakrishna, Chandran, Cantin, Edouard, An, Dong Sung, Sun, Ren, Wu, Ting-Ting, Jung, Jae U., Savic, Sinisa, Gwack, Yousang

“…Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I interferon response to DNA…”
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Orai1 is an essential pore subunit of the CRAC channel by Rao, Anjana, Prakriya, Murali, Feske, Stefan, Gwack, Yousang, Srikanth, Sonal, Hogan, Patrick G

“…Stimulation of immune cells causes depletion of Ca2+ from endoplasmic reticulum (ER) stores, thereby triggering sustained Ca2+ entry through store-operated…”
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The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1 by Woo, Jin Seok, Sun, Zuoming, Srikanth, Sonal, Gwack, Yousang

“…Ca 2+ release-activated Ca 2+ (CRAC) channels elevate cytoplasmic Ca 2+ concentration, which is essential for T cell activation, differentiation and effector…”
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ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4 by Choi, Dongwon, Park, Eunkyung, Jung, Eunson, Seong, Young Jin, Hong, Mingu, Lee, Sunju, Burford, James, Gyarmati, Georgina, Peti-Peterdi, Janos, Srikanth, Sonal, Gwack, Yousang, Koh, Chester J, Boriushkin, Evgenii, Hamik, Anne, Wong, Alex K, Hong, Young-Kwon

“…RATIONALE:Lymphatic vessels function to drain interstitial fluid from a variety of tissues. Although shear stress generated by fluid flow is known to trigger…”
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Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria by Kim, Ji-Hee, Hwang, Kyu-Hee, Dang, Bao T. N., Eom, Minseob, Kong, In Deok, Gwack, Yousang, Yu, Seyoung, Gee, Heon Yung, Birnbaumer, Lutz, Park, Kyu-Sang, Cha, Seung-Kuy

“…Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca 2+ signaling whose perturbation leads to…”
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Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+ dynamics in T cells by Woo, Jin Seok, Srikanth, Sonal, Nishi, Miyuki, Ping, Peipei, Takeshima, Hiroshi, Gwack, Yousang

“…Orai1 and stromal interaction molecule 1 (STIM1) mediate store-operated Ca2+ entry (SOCE) in immune cells. STIM1, an endoplasmic reticulum (ER) Ca2+ sensor,…”
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Laminar flow downregulates Notch activity to promote lymphatic sprouting by Choi, Dongwon, Park, Eunkyung, Jung, Eunson, Seong, Young Jin, Yoo, Jaehyuk, Lee, Esak, Hong, Mingu, Lee, Sunju, Ishida, Hiroaki, Burford, James, Peti-Peterdi, Janos, Adams, Ralf H, Srikanth, Sonal, Gwack, Yousang, Chen, Christopher S, Vogel, Hans J, Koh, Chester J, Wong, Alex K, Hong, Young-Kwon

“…The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional drainage causes increased fluid flow that triggers lymphatic…”
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Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1) by Srikanth, Sonal, Jew, Marcus, Kim, Kyun-Do, Yee, Ma-Khin, Abramson, Jeff, Gwack, Yousang

“…Orai1 and stromal interaction molecule (STIM)1 are critical components of Ca2+ release-activated Ca2+ (CRAC) channels. Orai1 is a pore subunit of CRAC…”
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Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A ) cause a primary immunodeficiency disorder by Wu, Beibei, Rice, Laura, Shrimpton, Jennifer, Lawless, Dylan, Walker, Kieran, Carter, Clive, McKeown, Lynn, Anwar, Rashida, Doody, Gina M, Srikanth, Sonal, Gwack, Yousang, Savic, Sinisa

“…CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor…”
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Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models by Howard, Emily, Hurrell, Benjamin P., Helou, Doumet Georges, Shafiei-Jahani, Pedram, Hasiakos, Spyridon, Painter, Jacob, Srikanth, Sonal, Gwack, Yousang, Akbari, Omid

“…Ca 2+ entry via Ca 2+ release-activated Ca 2+ (CRAC) channels is a predominant mechanism of intracellular Ca 2+ elevation in immune cells. Here we show the…”
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Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection by Zhong, Xiancai, Wu, Hongmin, Zhang, Wencan, Shi, Yun, Gwack, Yousang, Xue, Hai-hui, Sun, Zuoming

“…T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17…”
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Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt by He, Zhiheng, Wang, Fei, Zhang, Jing, Sen, Subha, Pang, Qihua, Luo, Shengwei, Gwack, Yousang, Sun, Zuoming

“…Transcription factor retinoid acid-related orphan receptor (ROR)γt transcriptionally regulates the genes required for differentiation of Th17 cells that…”
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CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses by Woo, Jin Seok, Srikanth, Sonal, Kim, Kyun-Do, Elsaesser, Heidi, Lu, Jing, Pellegrini, Matteo, Brooks, David G, Sun, Zuoming, Gwack, Yousang

“…Ca release-activated Ca channel regulator 2A (CRACR2A) is expressed abundantly in T cells and acts as a signal transmitter between TCR stimulation and…”
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Biochemical and Functional Characterization of Orai Proteins by Gwack, Yousang, Srikanth, Sonal, Feske, Stefan, Cruz-Guilloty, Fernando, Oh-hora, Masatsugu, Neems, Daniel S., Hogan, Patrick G., Rao, Anjana

“…Stimulation of immune cells triggers Ca2+ entry through store-operated Ca2+ release-activated Ca2+ channels, promoting nuclear translocation of the…”
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The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+ Release-activated Ca2+ Channels by Srikanth, Sonal, Jung, Hea-Jin, Ribalet, Bernard, Gwack, Yousang

“…Store-operated Ca 2+ entry (SOCE) due to activation of Ca 2+ release-activated Ca 2+ (CRAC) channels leads to sustained elevation of cytoplasmic Ca 2+ and…”
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Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1 by Gwack, Yousang, Srikanth, Sonal, Oh-hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, Gelinas, Curtis, Neems, Daniel S., Sasaki, Yoshiteru, Feske, Stefan, Prakriya, Murali, Rajewsky, Klaus, Rao, Anjana

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells by Wu, Beibei, Woo, Jin Seok, Vila, Pamela, Jew, Marcus, Leung, Jennifer, Sun, Zuoming, Srikanth, Sonal, Gwack, Yousang

“…Sustained activation of the Ca2+-release-activated Ca2+ (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability…”
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Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis by Groenendyk, Jody, Peng, Zhenling, Dudek, Elzbieta, Fan, Xiao, Mizianty, Marcin J, Dufey, Estefanie, Urra, Hery, Sepulveda, Denisse, Rojas-Rivera, Diego, Lim, Yunki, Kim, Do Han, Baretta, Kayla, Srikanth, Sonal, Gwack, Yousang, Ahnn, Joohong, Kaufman, Randal J, Lee, Sun-Kyung, Hetz, Claudio, Kurgan, Lukasz, Michalak, Marek

“…The disruption of the energy or nutrient balance triggers endoplasmic reticulum (ER) stress, a process that mobilizes various strategies, collectively called…”
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Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation by Kim, Kyun-Do, Srikanth, Sonal, Tan, Yossan-Var, Yee, Ma-Khin, Jew, Marcus, Damoiseaux, Robert, Jung, Michael E, Shimizu, Saki, An, Dong Sung, Ribalet, Bernard, Waschek, James A, Gwack, Yousang

“…Orai1 is the pore subunit of Ca(2+) release-activated Ca(2+) (CRAC) channels that stimulate downstream signaling pathways crucial for T cell activation. CRAC…”
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Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells by Lee, Sung Hee, Park, Yongtae, Song, Minju, Srikanth, Sonal, Kim, Sol, Kang, Mo K., Gwack, Yousang, Park, No-Hee, Kim, Reuben H., Shin, Ki-Hyuk

“…Orai1 is a pore-subunit of store-operated Ca2+ release-activated Ca2+ (CRAC) channel that mediates Ca2+ influx in most non-excitable cells via store-operated…”
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