Search Results - "Guzzolino, Elena"
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miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish
Published in Cellular and molecular life sciences : CMLS (01-08-2020)“…To dissect the TBX5 regulatory circuit, we focused on microRNAs (miRNAs) that collectively contribute to make TBX5 a pivotal cardiac regulator. We profiled…”
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The landscape of BRAF transcript and protein variants in human cancer
Published in Molecular cancer (28-04-2017)“…The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood…”
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Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish
Published in Journal of cardiovascular development and disease (12-01-2022)“…Heart valve development is governed by both genetic and biomechanical inputs. Prior work has demonstrated that oscillating shear stress associated with blood…”
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Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish
Published in Frontiers in cell and developmental biology (05-06-2018)“…Sphingosine-1-phosphate is a bioactive lipid and a signaling molecule integrated into many physiological systems such as differentiation, proliferation and…”
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New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way
Published in International journal of environmental research and public health (24-10-2020)“…In recent years, the presence in the environment of chemical compounds with thyroid-disrupting effects is progressively increased. This phenomenon has risen…”
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Biosafety and Biokinetics of Noble Metals: The Impact of Their Chemical Nature
Published in ACS applied bio materials (21-10-2019)“…Effective excretion of nanostructured noble metals is still one of the most challenging bottlenecks for their employment in clinical practice. Besides the…”
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Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF -X1 mRNA
Published in RNA biology (03-07-2019)“…Here we present miR-CATCHv2.0, an implemented experimental method that allows the identification of the microRNA species directly bound to an RNA of interest…”
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Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells
Published in Oncotarget (11-04-2017)“…Despite increasing amounts of experimental evidence depicting the involvement of non-coding RNAs in cancer, the study of BRAFV600E-regulated genes has thus far…”
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Abstract 602: Mir-182-5p is a Conserved Downstream Effector of Tbx5 Involved in Heart Development and Arrhythmia in Zebrafish
Published in Circulation research (02-08-2019)“…Abstract only Background: TBX5 mutations cause Holt-Oram syndrome (HOS) characterized by upper limb and cardiac malformations, but can also contribute to…”
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MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome
Published in Scientific reports (14-12-2015)“…Holt-Oram Syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene, a transcription factor capable of regulating…”
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Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF-X1 mRNA
Published in RNA Biology (03-07-2019)“…Here we present miR-CATCHv2.0, an implemented experimental method that allows the identification of the microRNA species directly bound to an RNA of interest…”
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