Search Results - "Guzowski, John F"

Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus by Czerniawski, Jennifer, Guzowski, John F

“…Although it is known that immune system activation can impair cognition, no study to date has linked cognitive deficits during acute neuroinflammation to…”
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Differences in Hippocampal Neuronal Population Responses to Modifications of an Environmental Context: Evidence for Distinct, Yet Complementary, Functions of CA3 and CA1 Ensembles by Vazdarjanova, Almira, Guzowski, John F

“…Understanding how the hippocampus processes information critical for establishing spatial and declarative memories will benefit greatly from determining not…”
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Neuronal Competition and Selection during Memory Formation by Han, Jin-Hee, Kushner, Steven A., Yiu, Adelaide P., Cole, Christy J., Matynia, Anna, Brown, Robert A., Neve, Rachael L., Guzowski, John F., Silva, Alcino J., Josselyn, Sheena A.

“…Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in…”
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Rapid Activation of Plasticity-Associated Gene Transcription in Hippocampal Neurons Provides a Mechanism for Encoding of One-Trial Experience by Miyashita, Teiko, Kubik, Stepan, Haghighi, Nahideh, Steward, Oswald, Guzowski, John F

“…The hippocampus is hypothesized to support rapid encoding of ongoing experience. A critical prerequisite for such function is the ability to readily recruit…”
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Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain by Vazdarjanova, Almira, Ramirez-Amaya, Victor, Insel, Nathan, Plummer, Thane K., Rosi, Susanna, Chowdhury, Shoaib, Mikhael, Dalia, Worley, Paul F., Guzowski, John F., Barnes, Carol A.

“…Active behavior, such as exploring a novel environment, induces the expression of the immediate‐early gene Arc (activity‐regulated cytoskeletal associated…”
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Ensemble Dynamics of Hippocampal Regions CA3 and CA1 by Guzowski, John F., Knierim, James J., Moser, Edvard I.

“…Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative memory network, capable of…”
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Networks of neurons, networks of genes: An integrated view of memory consolidation by Miyashita, Teiko, Kubik, Stepan, Lewandowski, Gail, Guzowski, John F.

“…Investigations into the mechanisms of memory formation have abided by the central tenet of the consolidation theory—that memory formation occurs in stages…”
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Temporal dynamics of Arc gene induction in hippocampus: Relationship to context memory formation by Pevzner, Aleksandr, Miyashita, Teiko, Schiffman, Aaron J., Guzowski, John F.

“…► Brief exposure to a context results in rapid induction of hippocampal Arc. ► Arc in CA3 was maximal with 3s of exposure, while CA1 required 30s exposure. ►…”
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Memory-Influencing Intra-Basolateral Amygdala Drug Infusions Modulate Expression of Arc Protein in the Hippocampus by McIntyre, Christa K., Miyashita, Teiko, Setlow, Barry, Marjon, Kristopher D., Steward, Oswald, Guzowski, John F., McGaugh, James L.

“…Activation of β-adrenoceptors in the basolateral complex of the amygdala (BLA) modulates memory storage processes and longterm potentiation in downstream…”
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Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles by Guzowski, John F, McNaughton, Bruce L, Barnes, Carol A, Worley, Paul F

“…We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in…”
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Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory by Guzowski, John F, Lyford, Gregory L, Stevenson, Gail D, Houston, Frank P, McGaugh, James L, Worley, Paul F, Barnes, Carol A

“…It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In…”
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Recent Behavioral History Modifies Coupling between Cell Activity and Arc Gene Transcription in Hippocampal CA1 Neurons by Guzowski, John F., Miyashita, Teiko, Chawla, Monica K., Sanderson, Jennifer, Maes, Levi I., Houston, Frank P., Lipa, Peter, McNaughton, Bruce L., Worley, Paul F., Barnes, Carol A.

“…The ability of neurons to alter their transcriptional programs in response to synaptic input is of fundamental importance to the neuroplastic mechanisms…”
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A hybrid 3D watershed algorithm incorporating gradient cues and object models for automatic segmentation of nuclei in confocal image stacks by Lin, Gang, Adiga, Umesh, Olson, Kathy, Guzowski, John F., Barnes, Carol A., Roysam, Badrinath

“…Background Automated segmentation of fluorescently‐labeled cell nuclei in 3D confocal microscope images is essential to many studies involving morphological…”
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Expression and Function of SNAP-25 as a Universal SNARE Component in GABAergic Neurons by Tafoya, Lawrence C. R, Mameli, Manuel, Miyashita, Teiko, Guzowski, John F, Valenzuela, C. Fernando, Wilson, Michael C

“…Intracellular vesicular trafficking and membrane fusion are important processes for nervous system development and for the function of neural circuits…”
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Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats by Lomeli, Naomi, Di, Kaijun, Czerniawski, Jennifer, Guzowski, John F., Bota, Daniela A.

“…Chemotherapy-related cognitive impairment (CRCI) is commonly reported following the administration of chemotherapeutic agents and comprises a wide variety of…”
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Systemic lipopolysaccharide administration impairs retrieval of context–object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation by Czerniawski, Jennifer, Miyashita, Teiko, Lewandowski, Gail, Guzowski, John F

“…Highlights • We tested if acute neuroinflammation impairs retrieval of different memory tasks. • Systemic LPS administration was used to induce acute…”
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Synaptic Activity-Induced Conversion of Intronic to Exonic Sequence in Homer 1 Immediate Early Gene Expression by Bottai, Daniele, Guzowski, John F, Schwarz, Martin K, Kang, Shin H, Xiao, Bo, Lanahan, Anthony, Worley, Paul F, Seeburg, Peter H

“…Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and…”
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The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function by Bramham, Clive R, Worley, Paul F, Moore, Melissa J, Guzowski, John F

“…In a manner unique among activity-regulated immediate early genes (IEGs), mRNA encoded by Arc (also known as Arg3.1) undergoes rapid transport to dendrites and…”
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A Form of Perforant Path LTP Can Occur without ERK1/2 Phosphorylation or Immediate Early Gene Induction by Steward, Oswald, Huang, Fen, Guzowski, John F

“…Stimulation paradigms that induce perforant path long-term potentiation (LTP) initiate phosphorylation of ERK1/2 and induce expression of a variety of…”
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Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice by Dickey, Chad A., Gordon, Marcia N., Mason, Jerimiah E., Wilson, Nedda J., Diamond, David M., Guzowski, John F., Morgan, Dave

“…Mice transgenic for mutated forms of the amyloid precursor protein (APP) plus presenilin‐1 (PS1) genes (APP + PS1 mice) gradually develop memory deficits which…”
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