Search Results - "Guy A. Zimmerman"

Platelets as Cellular Effectors of Inflammation in Vascular Diseases by Rondina, Matthew T, Weyrich, Andrew S, Zimmerman, Guy A

“…Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate…”
Get full text

Platelets in lung biology by Weyrich, Andrew S, Zimmerman, Guy A

“…Platelets and the lungs have an intimate relationship. Platelets are anucleate mammalian blood cells that continuously circulate through pulmonary vessels and…”
Get full text

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes by Rowley, Jesse W., Oler, Andrew J., Tolley, Neal D., Hunter, Benjamin N., Low, Elizabeth N., Nix, David A., Yost, Christian C., Zimmerman, Guy A., Weyrich, Andrew S.

“…Inbred mice are a useful tool for studying the in vivo functions of platelets. Nonetheless, the mRNA signature of mouse platelets is not known. Here, we use…”
Get full text

Sepsis alters the transcriptional and translational landscape of human and murine platelets by Middleton, Elizabeth A., Rowley, Jesse W., Campbell, Robert A., Grissom, Colin K., Brown, Samuel M., Beesley, Sarah J., Schwertz, Hansjörg, Kosaka, Yasuhiro, Manne, Bhanu K., Krauel, Krystin, Tolley, Neal D., Eustes, Alicia S., Guo, Li, Paine, Robert, Harris, Estelle S., Zimmerman, Guy A., Weyrich, Andrew S., Rondina, Matthew T.

“…There is increasing recognition that platelets have a functional role in the pathophysiology of sepsis, though this role has not been precisely defined…”
Get full text

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3 by Campbell, Robert A., Schwertz, Hansjorg, Hottz, Eugenio D., Rowley, Jesse W., Manne, Bhanu Kanth, Washington, A. Valance, Hunter-Mellado, Robert, Tolley, Neal D., Christensen, Miles, Eustes, Alicia S., Montenont, Emilie, Bhatlekar, Seema, Ventrone, Cassandra H., Kirkpatrick, Beth D., Pierce, Kristen K., Whitehead, Stephen S., Diehl, Sean A., Bray, Paul F., Zimmerman, Guy A., Kosaka, Yasuhiro, Bozza, Patricia T., Bozza, Fernando A., Weyrich, Andrew S., Rondina, Matthew T.

“…Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections…”
Get full text

VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock by Kaplan, David, Drs, Casper, T. Charles, Dr, Elliott, C. Gregory, Drs, Men, Shaohua, Mr, Pendleton, Robert C., MD, Kraiss, Larry W., Dr, Weyrich, Andrew S., Drs, Grissom, Colin K., MD, Zimmerman, Guy A., MD, Rondina, Matthew T., MD

“…BACKGROUND Prospective studies on the incidence of VTE during severe sepsis and septic shock remain absent, hindering efficacy assessments regarding VTE…”
Get full text

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation by Hottz, Eugenio D., Lopes, Juliana F., Freitas, Carla, Valls-de-Souza, Rogério, Oliveira, Marcus F., Bozza, Marcelo T., Da Poian, Andrea T., Weyrich, Andrew S., Zimmerman, Guy A., Bozza, Fernando A., Bozza, Patricia T.

“…Dengue is the most frequent hemorrhagic viral disease and re-emergent infection in the world. Although thrombocytopenia is characteristically observed in mild…”
Get full text

Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation by Yost, Christian C, Schwertz, Hansjörg, Cody, Mark J, Wallace, Jared A, Campbell, Robert A, Vieira-de-Abreu, Adriana, Araujo, Claudia V, Schubert, Sebastian, Harris, Estelle S, Rowley, Jesse W, Rondina, Matthew T, Fulcher, James M, Koening, Curry L, Weyrich, Andrew S, Zimmerman, Guy A

“…Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMNs), extrude molecular lattices of decondensed chromatin studded with histones, granule…”
Get full text

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue by Trugilho, Monique Ramos de Oliveira, Hottz, Eugenio Damaceno, Brunoro, Giselle Villa Flor, Teixeira-Ferreira, André, Carvalho, Paulo Costa, Salazar, Gustavo Adolfo, Zimmerman, Guy A, Bozza, Fernando A, Bozza, Patrícia T, Perales, Jonas

“…Dengue is the most prevalent human arbovirus disease worldwide. Dengue virus (DENV) infection causes syndromes varying from self-limiting febrile illness to…”
Get full text

Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency by Chen, Karin, Coonrod, Emily M., Kumánovics, Attila, Franks, Zechariah F., Durtschi, Jacob D., Margraf, Rebecca L., Wu, Wilfred, Heikal, Nahla M., Augustine, Nancy H., Ridge, Perry G., Hill, Harry R., Jorde, Lynn B., Weyrich, Andrew S., Zimmerman, Guy A., Gundlapalli, Adi V., Bohnsack, John F., Voelkerding, Karl V.

“…Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by antibody deficiency, poor humoral response to antigens, and recurrent…”
Get full text

Platelets: signaling cells in the immune continuum by Weyrich, Andrew S., Zimmerman, Guy A.

“…Platelets have intricate signaling mechanisms and participate in a breadth of cellular interactions. This diversity is frequently unrecognized. In addition to…”
Get full text

Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation by Kraemer, Bjoern F, Campbell, Robert A, Schwertz, Hansjörg, Cody, Mark J, Franks, Zechariah, Tolley, Neal D, Kahr, Walter H A, Lindemann, Stephan, Seizer, Peter, Yost, Christian C, Zimmerman, Guy A, Weyrich, Andrew S

“…Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human…”
Get full text

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates by Yost, Christian C., Cody, Mark J., Harris, Estelle S., Thornton, Nathan L., McInturff, Alison M., Martinez, Mark L., Chandler, Nancy B., Rodesch, Christopher K., Albertine, Kurt H., Petti, Cathy A., Weyrich, Andrew S., Zimmerman, Guy A.

“…Neutrophils are highly specialized innate effector cells that have evolved for killing of pathogens. Human neonates have a common multifactorial syndrome of…”
Get full text

Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals by Mesquita, Emersom C., Hottz, Eugenio D., Amancio, Rodrigo T., Carneiro, Alan B., Palhinha, Lohanna, Coelho, Lara E., Grinsztejn, Beatriz, Zimmerman, Guy A., Rondina, Matthew T., Weyrich, Andrew S., Bozza, Patrícia T., Bozza, Fernando A.

“…Cardiovascular diseases and thrombotic events became major clinical problems in the combined antiretroviral therapy (cART) era. Although the precise mechanisms…”
Get full text

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza by London, Nyall R, Zhu, Weiquan, Bozza, Fernando A, Smith, Matthew C P, Greif, Daniel M, Sorensen, Lise K, Chen, Luming, Kaminoh, Yuuki, Chan, Aubrey C, Passi, Samuel F, Day, Craig W, Barnard, Dale L, Zimmerman, Guy A, Krasnow, Mark A, Li, Dean Y

“…The innate immune system provides a first line of defense against invading pathogens by releasing multiple inflammatory cytokines, such as interleukin-1beta…”
Get more information

In Vivo Platelet Activation in Critically Ill Patients With Primary 2009 Influenza A(H1N1) by Rondina, Matthew T., MD, Brewster, BreAnna, Grissom, Colin K., MD, FCCP, Zimmerman, Guy A., MD, Kastendieck, Diana H., BA, Harris, Estelle S., MD, FCCP, Weyrich, Andrew S., PhD

“…Background Changes in platelet reactivity during 2009 influenza A(H1N1) (A[H1N1]) have not been characterized. Methods We prospectively examined platelet…”
Get full text

Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA–DNA Hybrids by Schwertz, Hansjörg, Rowley, Jesse W, Schumann, Gerald G, Thorack, Ulrike, Campbell, Robert A, Manne, Bhanu Kanth, Zimmerman, Guy A, Weyrich, Andrew S, Rondina, Matthew T

“…OBJECTIVE—One source of endogenous reverse transcriptase (eRT) activity in nucleated cells is the LINE-1/L1 (long interspersed nuclear element-1), a non-LTR…”
Get full text

Anucleate platelets generate progeny by Schwertz, Hansjörg, Köster, Sarah, Kahr, Walter H.A., Michetti, Noemi, Kraemer, Bjoern F., Weitz, David A., Blaylock, Robert C., Kraiss, Larry W., Greinacher, Andreas, Zimmerman, Guy A., Weyrich, Andrew S.

“…Platelets are classified as terminally differentiated cells that are incapable of cellular division. However, we observe that anucleate human platelets, either…”
Get full text

Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets by Schwertz, Hansjörg, Tolley, Neal D., Foulks, Jason M., Denis, Melvin M., Risenmay, Ben W., Buerke, Michael, Tilley, Rachel E., Rondina, Matthew T., Harris, Estelle M., Kraiss, Larry W., Mackman, Nigel, Zimmerman, Guy A., Weyrich, Andrew S.

“…Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA…”
Get full text

Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets by Denis, Melvin M., Tolley, Neal D., Bunting, Michaeline, Schwertz, Hansjörg, Jiang, Huimiao, Lindemann, Stephan, Yost, Christian C., Rubner, Frederick J., Albertine, Kurt H., Swoboda, Kathryn J., Fratto, Carolyn M., Tolley, Emilysa, Kraiss, Larry W., McIntyre, Thomas M., Zimmerman, Guy A., Weyrich, Andrew S.

“…Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts. We report that platelets unexpectedly possess a functional…”
Get full text