Search Results - "Guy, Mark R"

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases by Guy, Mark R, Illarionov, Petr A, Gurcha, Sudagar S, Dover, Lynn G, Gibson, Kevin J C, Smith, Paul W, Minnikin, David E, Besra, Gurdyal S

“…PPM (polyprenol monophosphomannose) has been shown to act as a glycosyl donor in the biosynthesis of the Man (mannose)-rich mycobacterial lipoglycans LM…”
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Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation by Moody, D. Branch, Briken, Volker, Cheng, Tan-Yun, Roura-Mir, Carme, Guy, Mark R, Geho, David H, Tykocinski, Mark L, Besra, Gurdyal S, Porcelli, Steven A

“…CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses…”
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Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells by MOODY, D. B, REINHOLD, B. B, BESRA, G. S, PORCELLI, S. A, GUY, M. R, BECKMAN, E. M, FREDERIQUE, D. E, FURLONG, S. T, YE, S, REINHOLD, V. N, SIELING, P. A, MODLIN, R. L

“…The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM)…”
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Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes inMycobacterium tuberculosis by Kremer, Laurent, Douglas, James D., Baulard, Alain R., Morehouse, Caroline, Guy, Mark R., Alland, David, Dover, Lynn G., Lakey, Jeremy H., Jacobs, William R., Brennan, Patrick J., Minnikin, David E., Besra, Gurdyal S.

“…Prevention efforts and control of tuberculosis are seriously hampered by the appearance of multidrug-resistant strains of Mycobacterium tuberculosis, dictating…”
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Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis by Kremer, L, Douglas, J D, Baulard, A R, Morehouse, C, Guy, M R, Alland, D, Dover, L G, Lakey, J H, Jacobs, Jr, W R, Brennan, P J, Minnikin, D E, Besra, G S

“…Prevention efforts and control of tuberculosis are seriously hampered by the appearance of multidrug-resistant strains of Mycobacterium tuberculosis, dictating…”
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CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection by Moody, D B, Guy, M R, Grant, E, Cheng, T Y, Brenner, M B, Besra, G S, Porcelli, S A

“…T cells recognize microbial glycolipids presented by CD1 proteins, but there is no information regarding the generation of natural glycolipid antigens within…”
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Structural Requirements for Glycolipid Antigen Recognition by CD 1b- Restricted T Cells by Moody, D. Branch, Reinhold, Bruce B., Guy, Mark R., Beckman, Evan M., Frederique, Daphney E., Furlong, Stephen T., Ye, Song, Reinhold, Vernon N., Sieling, Peter A., Modlin, Robert L., Besra, Gurdyal S., Porcelli, Steven A.

“…The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM)…”
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