Search Results - "Guy, H R"

Stratum Corneum Sampling to Assess Bioequivalence between Topical Acyclovir Products by Pensado, A., Chiu, W.S., Cordery, S. F., Rantou, E., Bunge, A. L., Delgado-Charro, M. B., Guy, R. H.

“…Purpose To examine the potential of stratum corneum (SC) sampling via tape-stripping in humans to assess bioequivalence of topical acyclovir drug products, and…”
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Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients by Kroes, R., Renwick, A.G., Feron, V., Galli, C.L., Gibney, M., Greim, H., Guy, R.H., Lhuguenot, J.C., van de Sandt, J.J.M.

“…The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The…”
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Skin penetration and distribution of polymeric nanoparticles by Alvarez-Román, R., Naik, A., Kalia, Y.N., Guy, R.H., Fessi, H.

“…Encapsulation using nanoparticulate systems is an increasingly implemented strategy in drug targeting and delivery. Such systems have also been proposed for…”
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Effect of Aqueous Cream BP on human stratum corneum in vivo by Tsang, M., Guy, R.H.

“…Summary Background  Aqueous Cream BP is widely prescribed to patients with eczema to relieve skin dryness. The formulation contains sodium lauryl sulphate…”
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Topical bioavailability of diclofenac from locally-acting, dermatological formulations by Cordery, S.F., Pensado, A., Chiu, W.S., Shehab, M.Z., Bunge, A.L., Delgado-Charro, M.B., Guy, R.H.

“…[Display omitted] Assessment of the bioavailability of topically applied drugs designed to act within or beneath the skin is a challenging objective. A number…”
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Visualization of skin penetration using confocal laser scanning microscopy by Alvarez-Román, R, Naik, A, Kalia, Y.N, Fessi, H, Guy, R.H

“…The use of skin as an alternative route for administering systemically active drugs has attracted considerable interest in recent years. However, the skin…”
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Applications of nanoparticles in topical drug delivery and in cosmetics by Wu, X., Guy, R.H.

“…The delivery of drugs and active agents to the skin by formulations containing nanoparticles is a topic of considerable current interest. A number of studies…”
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Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo by Sekkat, N, Kalia, Y N, Guy, R H

“…The goal of this work was to establish, using biophysical characterization, that porcine ear skin in vitro is a valid model for its human counterpart…”
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Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping by Mohammed, D., Yang, Q., Guy, R.H., Matts, P.J., Hadgraft, J., Lane, M.E.

“…Correlation between the protein content on each tape and the corresponding weight of SC present (n=240). Skin surface tape-stripping is an extensively used…”
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Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability by Wiedersberg, S., Naik, A., Leopold, C.S., Guy, R.H.

“…Summary Background  The bioavailability of most topically delivered drugs is difficult to quantify, but is generally believed to be very low. With the…”
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In vivo infrared spectroscopy studies of alkanol effects on human skin by Dias, M., Naik, A., Guy, R.H., Hadgraft, J., Lane, M.E.

“…Many studies investigate the permeation of actives through the skin and ignore the role of excipients. The solvents used in formulations will undoubtedly…”
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Extraction and quantification of amino acids in human stratum corneum in vivo by Sylvestre, J.-P., Bouissou, C.C., Guy, R.H., Delgado-Charro, M.B.

“…Summary Background  Amino acid (AA) levels in stratum corneum (SC) are potential biomarkers of skin health while their systemic levels may be used to diagnose…”
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Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations by Grégoire, S., Ribaud, C., Benech, F., Meunier, J.R., Garrigues-Mazert, A., Guy, R.H.

“…Summary Background  To date, risk assessment following topical exposure to cosmetic/dermatological formulations cannot be precisely evaluated. Objectives  To…”
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The gating mechanism of the large mechanosensitive channel MscL by Sukharev, S., Betanzos, M., Chiang, C. S., Guy, H. R.

“…The mechanosensitive channel of large conductance, MscL, is a ubiquitous membrane-embedded valve involved in turgor regulation in bacteria. The crystal…”
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Measurement and prediction of the rate and extent of drug delivery into and through the skin by Russell, L M, Guy, R H

“…Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation…”
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Structural Models of the MscL Gating Mechanism by Sukharev, Sergei, Durell, Stewart R., Guy, H. Robert

“…Three-dimensional structural models of the mechanosensitive channel of large conductance, MscL, from the bacteria Mycobacterium tuberculosis and Escherichia…”
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Predicting skin permeability by POTTS, R. O, GUY, R. H

“…Published permeability coefficient (Kp) data for the transport of a large group of compounds through mammalian epidermis were analyzed by a simple model based…”
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Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways by Alvarez-Román, R, Merino, G, Kalia, Y N, Naik, A, Guy, R H

“…The objective of this study was to shed light on the mechanism(s) by which low-frequency ultrasound (20 KHz) enhances the permeability of the skin. The…”
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Iontophoresis of dexamethasone phosphate: Competition with chloride ions by Sylvestre, J.-P., Díaz-Marín, C., Delgado-Charro, M.B., Guy, R.H.

“…The objective was to study the competition of chloride released from a Ag/AgCl cathode on the iontophoretic delivery of dexamethasone phosphate (Dex-Phos)…”
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Transdermal delivery from a lipid sponge phase—iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester by Merclin, N., Bender, J., Sparr, E., Guy, R.H., Ehrsson, H., Engström, S.

“…The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein,…”
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