Search Results - "Guy, C."

The endotoxin hypothesis of neurodegeneration by Brown, Guy C

“…The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration. Endotoxin is a lipopolysaccharide…”
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Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease by Vilalta, Anna, Brown, Guy C.

“…It was previously thought that neurons were phagocytosed only when dead or dying. However, it is increasingly clear that viable synapses, dendrites, axons and…”
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Living too long: The current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy by Brown, Guy C

“…Graphical Abstract Longer lifespans, often ending with multiple diseases, threaten the viability of social and health systems. Rather than prolonging life…”
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Cell death by phagocytosis by Brown, Guy C.

“…Cells can die as a consequence of being phagocytosed by other cells — a form of cell death that has been called phagotrophy, cell cannibalism, programmed cell…”
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Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons by Brown, Guy C

“…After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of neurons both in brain areas surrounding the infarct, known…”
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Living too long by Brown, Guy C

“…Longer lifespans, often ending with multiple diseases, threaten the viability of social and health systems. Rather than prolonging life further, research and…”
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How microglia kill neurons by Brown, Guy C, Vilalta, Anna

“…Abstract Microglia are resident brain macrophages that become inflammatory activated in most brain pathologies. Microglia normally protect neurons, but may…”
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Neuronal Cell Death by Fricker, Michael, Tolkovsky, Aviva M, Borutaite, Vilmante, Coleman, Michael, Brown, Guy C

“…Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to…”
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Nitric oxide and neuronal death by Brown, Guy C.

“…NO and its derivatives can have multiple effects, which impact on neuronal death in different ways. High levels of NO induces energy depletion-induced…”
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Microglial phagocytosis of live neurons by Brown, Guy C., Neher, Jonas J.

“…Microglia are known to remove dead and dying neurons in the brain by phagocytosis. In this Progress article, Brown and Neher discuss recent evidence indicating…”
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Atlantic Salmon (Salmo salar L.) Gastrointestinal Microbial Community Dynamics in Relation to Digesta Properties and Diet by Zarkasi, Kamarul Zaman, Taylor, Richard S, Abell, Guy C. J, Tamplin, Mark L, Glencross, Brett D, Bowman, John P

“…To better understand salmon GI tract microbial community dynamics in relation to diet, a feeding trial was performed utilising diets with different proportions…”
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Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’ by Brown, Guy C., Neher, Jonas J.

“…Phagoptosis, also called primary phagocytosis, is a recently recognised form of cell death caused by phagocytosis of viable cells, resulting in their…”
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Protodeboronation of Heteroaromatic, Vinyl, and Cyclopropyl Boronic Acids: pH–Rate Profiles, Autocatalysis, and Disproportionation by Cox, Paul A, Leach, Andrew G, Campbell, Andrew D, Lloyd-Jones, Guy C

“…pH–rate profiles for aqueous–organic protodeboronation of 18 boronic acids, many widely viewed as unstable, have been studied by NMR and DFT. Rates were…”
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Transmetalation in the Suzuki-Miyaura Coupling: The Fork in the Trail by Lennox, Alastair J. J., Lloyd-Jones, Guy C.

“…The Suzuki–Miyaura coupling is one of the few transition‐metal‐catalyzed CC bond‐forming reactions that have been used in applications ranging from discovery…”
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Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis by Neniskyte, Urte, Vilalta, Anna, Brown, Guy C.

“…•TNF-α induces neuronal loss in culture without neuronal necrosis or apoptosis.•TNF-α induces microglial phagocytosis, and the neuronal loss requires…”
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Microglial phagocytosis of neurons in neurodegeneration, and its regulation by Butler, Claire A., Popescu, Alma S., Kitchener, Emily J. A., Allendorf, David H., Puigdellívol, Mar, Brown, Guy C.

“…There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide…”
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Simple Parameters and Data Processing for Better Signal-to-Noise and Temporal Resolution in In Situ 1D NMR Reaction Monitoring by Flook, Annabel, Lloyd-Jones, Guy C.

“…In situ 1D NMR spectroscopic reaction monitoring allows detailed investigation of chemical kinetics and mechanism. Concentration versus time data are derived…”
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Base-Catalyzed Aryl-B(OH)2 Protodeboronation Revisited: From Concerted Proton Transfer to Liberation of a Transient Aryl Anion by Cox, Paul A, Reid, Marc, Leach, Andrew G, Campbell, Andrew D, King, Edward J, Lloyd-Jones, Guy C

“…Pioneering studies by Kuivila, published more than 50 years ago, suggested ipso protonation of the boronate as the mechanism for base-catalyzed…”
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Gold‐Triggered Uncaging Chemistry in Living Systems by Pérez‐López, Ana M., Rubio‐Ruiz, Belén, Sebastián, Víctor, Hamilton, Lloyd, Adam, Catherine, Bray, Thomas L., Irusta, Silvia, Brennan, Paul M., Lloyd‐Jones, Guy C., Sieger, Dirk, Santamaría, Jesús, Unciti‐Broceta, Asier

“…Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A…”
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Therapeutic hyperthermia: The old, the new, and the upcoming by Mallory, Matthew, Gogineni, Emile, Jones, Guy C, Greer, Lester, Simone, Charles B

“…Highlights • Hyperthermia continues to show clinical benefits in randomized trials across a spectrum of malignancies, with generally well-tolerated side…”
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