Search Results - "Guvenek, Aysegul"

Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution by Oz, Tugce, Guvenek, Aysegul, Yildiz, Sadik, Karaboga, Enes, Tamer, Yusuf Talha, Mumcuyan, Nirva, Ozan, Vedat Burak, Senturk, Gizem Hazal, Cokol, Murat, Yeh, Pamela, Toprak, Erdal

“…Revealing the genetic changes responsible for antibiotic resistance can be critical for developing novel antibiotic therapies. However, systematic studies…”
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Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance by Chevereau, Guillaume, Dravecká, Marta, Batur, Tugce, Guvenek, Aysegul, Ayhan, Dilay Hazal, Toprak, Erdal, Bollenbach, Tobias

“…The emergence of drug resistant pathogens is a serious public health problem. It is a long-standing goal to predict rates of resistance evolution and design…”
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Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation by Fontes, Mariana M., Guvenek, Aysegul, Kawaguchi, Riki, Zheng, Dinghai, Huang, Alden, Ho, Victoria M., Chen, Patrick B., Liu, Xiaochuan, O’Dell, Thomas J., Coppola, Giovanni, Tian, Bin, Martin, Kelsey C.

“…Long-lasting forms of synaptic plasticity that underlie learning and memory require new transcription and translation for their persistence. The remarkable…”
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Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs by Guvenek, Aysegul, Shin, Jihae, De Filippis, Lidia, Zheng, Dinghai, Wang, Wei, Pang, Zhiping P, Tian, Bin

“…RNA stability plays an important role in gene expression. Here, using 3' end sequencing of newly made and pre-existing poly(A)+ RNAs, we compare transcript…”
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Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration by Guvenek, Aysegul, Parikshak, Neelroop, Zamolodchikov, Daria, Gelfman, Sahar, Moscati, Arden, Dobbyn, Lee, Stahl, Eli, Shuldiner, Alan, Coppola, Giovanni

“…Microglia are the resident immune cells of the central nervous system and are involved in brain development, homeostasis, and disease. New imaging and genomics…”
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CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 by Shin, Jihae, Ding, Qingbao, Wang, Luyang, Cui, Yange, Baljinnyam, Erdene, Guvenek, Aysegul, Tian, Bin

“…Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have…”
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Alternative 3′ UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum by Cheng, Larry C., Zheng, Dinghai, Zhang, Qiang, Guvenek, Aysegul, Cheng, Hong, Tian, Bin

“…Transcripts encoding membrane and secreted proteins are known to associate with the endoplasmic reticulum (ER) through translation. Here, using cell…”
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ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5' splice site motifs within nuclear speckles by Lee, Eliza S, Smith, Harrison W, Wolf, Eric J, Guvenek, Aysegul, Wang, Yifan E, Emili, Andrew, Tian, Bin, Palazzo, Alexander F

“…Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear…”
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Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance: e1002299 by Chevereau, Guillaume, Dravecká, Marta, Batur, Tugce, Guvenek, Aysegul, Ayhan, Dilay Hazal, Toprak, Erdal, Bollenbach, Tobias

“…The emergence of drug resistant pathogens is a serious public health problem. It is a long-standing goal to predict rates of resistance evolution and design…”
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Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions by Xiao, Brenda, Velez Edwards, Digna R, Lucas, Anastasia, Drivas, Theodore, Gray, Kathryn, Keating, Brendan, Weng, Chunhua, Jarvik, Gail P, Hakonarson, Hakon, Kottyan, Leah, Elhadad, Noemie, Wei, Wei-Qi, Luo, Yuan, Kim, Dokyoon, Ritchie, Marylyn, Verma, Shefali Setia

“…Background Cardiometabolic diseases are highly comorbid, but their relationship with female-specific or overwhelmingly female-predominant health conditions…”
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Biallelic BRCA Loss and Homologous Recombination Deficiency in Nonbreast/Ovarian Tumors in Germline BRCA1/2 Carriers by Wineland, Dylane, Le, Anh N, Hausler, Ryan, Kelly, Gregory, Barrett, Emanuel, Desai, Heena, Wubbenhorst, Bradley, Pluta, John, Bastian, Paul, Symecko, Heather, D'Andrea, Kurt, Doucette, Abigail, Gabriel, Peter, Reiss, Kim A, Nayak, Anupma, Feldman, Michael, Domchek, Susan M, Nathanson, Katherine L, Maxwell, Kara N

“…Breast and ovarian tumors in germline carriers undergo allele-specific loss of heterozygosity, resulting in homologous recombination deficiency (HRD) and…”
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Large-scale identification and analysis of suppressive drug interactions by Cokol, Murat, Weinstein, Zohar B, Yilancioglu, Kaan, Tasan, Murat, Doak, Allison, Cansever, Dilay, Mutlu, Beste, Li, Siyang, Rodriguez-Esteban, Raul, Akhmedov, Murodzhon, Guvenek, Aysegul, Cokol, Melike, Cetiner, Selim, Giaever, Guri, Iossifov, Ivan, Nislow, Corey, Shoichet, Brian, Roth, Frederick P

“…One drug may suppress the effects of another. Although knowledge of drug suppression is vital to avoid efficacy-reducing drug interactions or discover…”
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