Search Results - "Guvakova, Marina A"

The g3mclass is a practical software for multiclass classification on biomarkers by Guvakova, Marina A., Sokol, Serguei

“…The analytes qualified as biomarkers are potent tools to diagnose various diseases, monitor therapy responses, and design therapeutic interventions. The early…”
Get full text

The small GTPase Rap1 promotes cell movement rather than stabilizes adhesion in epithelial cells responding to insulin-like growth factor I by Guvakova, Marina A, Lee, William S Y, Furstenau, Dana K, Prabakaran, Indira, Li, David C, Hung, Rupert, Kushnir, Natasha

“…The Ras-related GTPase Rap1 promotes cell adhesion and migration. Although the significance of Rap1 contribution to cell migration is increasingly being…”
Get more information

Automated Classification of Breast Cancer Across the Spectrum of ERBB2 Expression Focusing on Heterogeneous Tumors With Low Human Epidermal Growth Factor Receptor 2 Expression by Guvakova, Marina A

“…Although pharmaceutical companies conduct clinical trials of novel human epidermal growth factor receptor 2 (HER2)-low-directed drugs, diagnosing HER2-low…”
Get more information

Gaussian Mixture Models for Probabilistic Classification of Breast Cancer by Prabakaran, Indira, Wu, Zhengdong, Lee, Changgun, Tong, Brian, Steeman, Samantha, Koo, Gabriel, Zhang, Paul J, Guvakova, Marina A

“…In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To…”
Get full text

Improving patient classification and biomarker assessment using Gaussian Mixture Models and Bayes' rule by Guvakova, Marina A

“…In clinical research, determining cutoff values for continuous variables in test results remains challenging, particularly when considering candidate…”
Get full text

Insulin-like growth factors control cell migration in health and disease by Guvakova, Marina A.

“…Insulin-like growth factors I and II (IGF-I and IGF-II) have an ancient origin and play essential roles in fundamental biological processes. Although IGFs are…”
Get full text

Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer by Grau, Jillian R., Lewis, Robert, Fraker, Douglas L., Guvakova, Marina A., Prabakaran, Indira

“…The development of molecular biomarkers (BMs) of follicular thyroid carcinoma is aimed at advancing diagnosis of follicular neoplasm, as histological…”
Get full text

CDH2/N-cadherin and early diagnosis of invasion in patients with ductal carcinoma in situ by Guvakova, Marina A., Prabakaran, Indira, Wu, Zhengdong, Hoffman, Daniel I., Huang, Ye, Tchou, Julia, Zhang, Paul J.

“…Purpose This proof-of-concept study investigates gene expression in core needle biopsies (CNB) to predict whether individuals diagnosed with ductal carcinoma…”
Get full text

Ras-related protein 1 and the insulin-like growth factor type I receptor are associated with risk of progression in patients diagnosed with carcinoma in situ by Furstenau, Dana K., Mitra, Nandita, Wan, Fei, Lewis, Robert, Feldman, Michael D., Fraker, Douglas L., Guvakova, Marina A.

“…Currently, there are no applied molecular markers to aid in predicting risk of carcinoma in situ (CIS) progression to invasive cancer, and therefore, all women…”
Get full text

Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells by GUVAKOVA, M. A, SURMACZ, E

“…The insulin-like growth factor I receptor (IGF-IR) is involved in the control of breast cancer cell growth. The cytostatic activity of tamoxifen (Tam), a…”
Get full text

Functional role of alpha-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells by Guvakova, Marina A, Adams, Josephine C, Boettiger, David

“…Within epithelial tissue, cells are held together by specialized lateral junctions. At particular stages of development and in pathological processes such as…”
Get full text

The Activated Insulin-Like Growth Factor I Receptor Induces Depolarization in Breast Epithelial Cells Characterized by Actin Filament Disassembly and Tyrosine Dephosphorylation of FAK, Cas, and Paxillin by Guvakova, Marina A., Surmacz, Ewa

“…Insulin-like growth factor I (IGF-I) promotes the motility of different cell types. We investigated the role of IGF-I receptor (IGF-IR) signaling in locomotion…”
Get full text

Vav2 protein overexpression marks and may predict the aggressive subtype of ductal carcinoma in situ by Jiang, YunQing, Prabakaran, Indira, Wan, Fei, Mitra, Nandita, Furstenau, Dana K, Hung, Rupert K, Cao, Siyuan, Zhang, Paul J, Fraker, Douglas L, Guvakova, Marina A

“…A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective predictive biomarkers for…”
Get full text

Phosphorothioate Oligodeoxynucleotides Bind to Basic Fibroblast Growth Factor, Inhibit Its Binding to Cell Surface Receptors, and Remove It from Low Affinity Binding Sites on Extracellular Matrix (∗) by Guvakova, Marina A., Yakubov, Leonid A., Vlodavsky, Israel, Tonkinson, John L., Stein, C.A.

“…We studied the interactions of phosphorothioate oligodeoxynucleotides and heparin-binding growth factors. By means of a gel mobility shift assay, we…”
Get full text

Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor by Guvakova, Marina A., Boettiger, David, Adams, Josephine C.

“…Insulin-like growth factor-I receptor (IGF-IR) signaling contributes to the formation of mammary carcinomas and has chiefly been studied with regard to the…”
Get full text

Type I insulin-like growth factor receptor function in breast cancer by Surmacz, E, Guvakova, M A, Nolan, M K, Nicosia, R F, Sciacca, L

“…Experimental evidence suggests an important role of the type I IGF receptor (IGF-IR) in breast cancer development. Breast tumors and breast cancer cell lines…”
Get full text

Abstract 5283: Vav2 oncoprotein up regulation may predict the aggressive subtype of ductal carcinoma in situ by Guvakova, Marina A., Jiang, Yun Qing, Prabakaran, Indira, Wan, Fei, Mitra, Nandita, Zhang, Paul J., Fraker, Douglas L.

“…Abstract Background: A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective…”
Get full text

Insulin-like Growth Factor I Controls Adhesion Strength Mediated by α5β1 Integrins in Motile Carcinoma Cells by Lynch, Laura, Vodyanik, Pavel I., Boettiger, David, Guvakova, Marina A.

“…One of the intriguing questions regarding cell motility concerns the mechanism that makes stationary cells move. Here, we provide the first physical evidence…”
Get full text

Abstract B40: The quest for biomarkers of progressive DCIS using archived tissue by Guvakova, Marina A., Jiang, YunQing, Prabakaran, Indira, Wan, Fei, Mitra, Nandita, Fraker, Douglas L., Zhang, Paul J.

“…Abstract Background: Presently, an indolent ductal carcinoma in situ (DCIS) cannot be distinguished from a progressive tumor, making the appropriate treatment…”
Get full text

High frequency of tumour cell reversion to non-tumorigenic phenotype by Lavrovsky, V A, Guvakova, M A, Lavrovsky, Y V

“…Nine spontaneously transformed cell lines were isolated from embryo fibroblasts of mice and rats with different genotypes. In six cell lines highly tumorigenic…”
Get more information