Search Results - "Gutting, Bradford W"

Ultraviolet dosage and decontamination efficacy were widely variable across 14 UV devices after testing a dried enveloped ribonucleic acid virus surrogate for SARS-CoV-2 by Buhr, Tony L, Borgers-Klonkowski, Erica, Gutting, Bradford W, Hammer, Emlyn E, Hamilton, Shelia M, Huhman, Brett M, Jackson, Stuart L, Kennihan, Neil L, Lilly, Samuel D, Little, Jr, John D, Luck, Brooke B, Matuczinski, Emily A, Miller, Charles T, Sides, Rachel E, Yates, Vanessa L, Young, Alice A

“…The dosages and efficacy of 14 ultraviolet (UV) decontamination technologies were measured against a SARS-CoV-2 surrogate virus that was dried onto different…”
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Hot, Humid Air Decontamination of Aircraft Confirmed That High Temperature and High Humidity Are Critical for Inactivation of Infectious, Enveloped Ribonucleic Acid (RNA) Virus by Buhr, Tony L, Young, Alice A, Borgers-Klonkowski, Erica, Kennihan, Neil L, Barnette, Harold K, Minter, Zachary A, Bohmke, Matthew D, Osborn, Emily B, Hamilton, Shelia M, Kimani, Monique B, Hammon, Mark W, Miller, Charles T, Mackie, Ryan S, Innocenti, Jennifer M, Bensman, Misty D, Gutting, Bradford W, Lilly, Samuel D, Hammer, Emlyn E, Yates, Vanessa L, Luck, Brooke B

“…To develop infectious (live/dead) enveloped virus test indicators and response surface methodology (RSM) models that evaluate survival of an enveloped…”
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Achieving consistent multiple daily low-dose Bacillus anthracis spore inhalation exposures in the rabbit model by Barnewall, Roy E, Comer, Jason E, Miller, Brian D, Gutting, Bradford W, Wolfe, Daniel N, Director-Myska, Alison E, Nichols, Tonya L, Taft, Sarah C

“…Repeated low-level exposures to biological agents could occur before or after the remediation of an environmental release. This is especially true for…”
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Dose-Response Modeling for Inhalational Anthrax in Rabbits Following Single or Multiple Exposures by Gutting, Bradford W., Rukhin, Andrey, Marchette, David, Mackie, Ryan S., Thran, Brandolyn

“…There is a need to advance our ability to characterize the risk of inhalational anthrax following a low‐dose exposure. The exposure scenario most often…”
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Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose-Response Model for Inhalational Anthrax in Nonhuman Primate, Rabbit, and Guinea Pig by Gutting, Bradford W., Rukhin, Andrey, Mackie, Ryan S., Marchette, David, Thran, Brandolyn

“…The application of the exponential model is extended by the inclusion of new nonhuman primate (NHP), rabbit, and guinea pig dose‐lethality data for inhalation…”
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Modeling low-dose mortality and disease incubation period of inhalational anthrax in the rabbit by Gutting, Bradford W., Marchette, David, Sherwood, Robert, Andrews, George A., Director-Myska, Alison, Channel, Stephen R., Wolfe, Daniel, Berger, Alan E., Mackie, Ryan S., Watson, Brent J., Rukhin, Andrey

“…There is a need to advance our ability to conduct credible human risk assessments for inhalational anthrax associated with exposure to a low number of…”
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Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida infection by Propst, Crystal N, Nwabueze, Albert O, Kanev, Igor L, Pepin, Rachel E, Gutting, Bradford W, Morozov, Victor N, van Hoek, Monique L

“…The Institute of Theoretical and Experimental Biophysics in Moscow recently developed a new nanoaerosol generator. This study evaluated this novel technology,…”
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Inhalational anthrax (Ames aerosol) in naïve and vaccinated New Zealand rabbits: characterizing the spread of bacteria from lung deposition to bacteremia by Gutting, Bradford W, Nichols, Tonya L, Channel, Stephen R, Gearhart, Jeffery M, Andrews, George A, Berger, Alan E, Mackie, Ryan S, Watson, Brent J, Taft, Sarah C, Overheim, Katie A, Sherwood, Robert L

“…There is a need to better understand inhalational anthrax in relevant animal models. This understanding could aid risk assessment, help define therapeutic…”
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Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG1 and IgE against co-injected TNP-OVA by GUTTING, Bradford W, UPDYKE, Lawrence W, AMACHER, David E

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BALB/c mice orally pretreated with diclofenac have augmented and accelerated PLNA responses to diclofenac by Gutting, Bradford W, Updyke, Lawrence W, Amacher, David E

“…The nonsteroidal anti-inflammatory drug (NSAID) diclofenac (DF) is associated with idiosyncratic hepatotoxicity and several other distinct hypersensitivity…”
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Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration by Gutting, Bradford W, Bouzahzah, Farida, Kong, Philip L, Updyke, Lawrence W, Amacher, David E, Craft, Joe

“…The murine popliteal lymph node assay (PLNA) was examined as a preclinical assay with the potential to identify low-molecular-weight compounds (LMWCs) that are…”
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Investigating the TNP-OVA and direct popliteal lymph node assays for the detection of immunostimulation by drugs associated with anaphylaxis in humans by Gutting, Bradford W., Updyke, Lawrence W., Amacher, David E.

“…Using current animal models, it is not possible to identify low‐molecular‐weight compounds (LMWCs) that are likely to be associated with anaphylaxis. It is…”
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Effect of animal sera on Bacillus anthracis Sterne spore germination and vegetative cell growth by Bensman, M.D., Mackie, R.S., Minter, Z.A., Gutting, B.W.

“…Aims:  The aims of this work were to investigate the effects of sera on B. anthracis Sterne germination and growth. Sera examined included human, monkey and…”
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Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG 1 and IgE against co-injected TNP–OVA by Gutting, Bradford W., Updyke, Lawrence W., Amacher, David E.

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently associated with immune-mediated hypersensitivity reactions. The NSAID diclofenac is associated…”
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Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG(1) and IgE against co-injected TNP-OVA by Gutting, Bradford W, Updyke, Lawrence W, Amacher, David E

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently associated with immune-mediated hypersensitivity reactions. The NSAID diclofenac is associated…”
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A comparison of the direct and reporter antigen popliteal lymph node assay for the detection of immunomodulation by low molecular weight compounds by GUTTING, B. W, SCHOMAKER, S. J, KAPLAN, A. H, AMACHER, D. E

“…The direct popliteal lymph node assay (PLNA) is a predictive test used to detect the immune-stimulating potential of pharmaceuticals and other low molecular…”
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