Search Results - "Gutteridge, W E"

Interactions of Atovaquone with Other Antimalarial Drugs against Plasmodium falciparum in Vitro by Canfield, C.J., Pudney, M., Gutteridge, W.E.

“…A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination with other antimalarial drugs…”
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Designer drugs: pipe-dreams or realities? by Gutteridge, W E

“…New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to…”
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Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis by HUGHES, W. T, GRAY, V. L, GUTTERIDGE, W. E, LATTER, V. S, PUDNEY, M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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TDR collaboration with the pharmaceutical industry by Gutteridge, W.E.

“…TDR's research programme was initiated in 1976 at the same time that the pharmaceutical industry began to withdraw from the discovery and development of new…”
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The activity of hydroxynaphthoquinones against Leishmania donovani by Croft, S L, Hogg, J, Gutteridge, W E, Hudson, A T, Randall, A W

“…The hydroxynaphthoquinones, buparvaquone, 250C80 and 56W82, showed high activity in vitro against Leishmania donovani amastigotes in mouse peritoneal…”
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In vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against the cyst form of Toxoplasma gondii by Araujo, F G, Huskinson-Mark, J, Gutteridge, W E, Remington, J S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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New tools for malaria therapy by Gutteridge, W E

“…In the absence of vaccines, new chemotherapies are needed urgently to help in the prevention and control of malaria. A number of strategies are being followed…”
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Existing chemotherapy and its limitations by Gutteridge, W E

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Purine and pyrimidine metabolism in the Trypanosomatidae by Hammond, D J, Gutteridge, W E

“…The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data…”
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566C80: a potent broad spectrum anti-infective agent with activity against malaria and opportunistic infections in AIDS patients by Hudson, A T, Dickins, M, Ginger, C D, Gutteridge, W E, Holdich, T, Hutchinson, D B, Pudney, M, Randall, A W, Latter, V S

“…566C80 is a novel hydroxynaphthoquinone with broad-spectrum anti-parasitic properties. In vitro the compound was more potent against Plasmodium falciparum than…”
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Parasite vaccines versus anti-parasite drugs: rivals or running mates? by Gutteridge, W E

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Nitric oxide synthase activity in malaria-infected mice by Jones, I W, Thomsen, L L, Knowles, R, Gutteridge, W E, Butcher, G A, Sinden, R E

“…Nitric oxide (NO) is implicated in a variety of major cellular functions including defence from invasion by microbical pathogens. Evidence has been presented…”
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Control of parasitic diseases: a complementary role for vaccines and drugs by Gutteridge, W E

“…This paper seeks to substantiate its title by discussion of three key questions: why are we attempting to develop parasite vaccines? Will we be successful? If…”
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Conversion of dihydroorotate to orotate in parasitic protozoa by Gutteridge, W E, Dave, D, Richards, W H

“…The conversion of dihydroorotate to orotate, one of the key reactions in the de novo pyrimidine biosynthetic pathway, has been studied in a number of parasitic…”
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New anti-protozoal agents by Gutteridge, W E

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A comparison of the interaction of anthelmintic benzimidazoles with tubulin isolated from mammalian tissue and the parasitic nematode Ascaridia galli by Dawson, P J, Gutteridge, W E, Gull, K

“…Colchicine and a range of anthelmintic benzimidazoles inhibited the in vitro polymerization of tubulin purified from the parasitic nematode Ascaridia galli. In…”
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The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicana by Davies, M J, Ross, A M, Gutteridge, W E

“…We have previously shown the presence of various purine salvage enzymes in Trypanosoma cruzi, including phosphoribosyltransferase, aminohydrolase, kinase,…”
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A strategy for the prevention of the transmission of Chagas' disease during blood transfusion by Hammond, D J, Croft, S L, Hogg, J, Gutteridge, W E

“…Our strategy for preventing the transmission of Chagas' disease during blood transfusion is discussed. In addition, the possibility that the Peru, Sonya,…”
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Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors by Guimarães, R C, Gutteridge, W E

“…1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late…”
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Trypanosoma cruzi: subcellular distribution of glycolytic and some related enzymes of epimastigotes by Taylor, M B, Gutteridge, W E

“…The first six glycolytic enzymes in epimastigote Trypanosoma cruzi were shown to behave similarly during differential centrifugation, when maximum relative…”
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