Search Results - "Gutteridge, C E"

An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents by Bhattacharjee, A K, Nichols, D A, Gerena, L, Roncal, N, Gutteridge, C E

“…Malaria, the most important of the human parasitic diseases, causes about 500 million infections worldwide and over 1 million deaths every year. The search for…”
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Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs by Gutteridge, C E, Vo, J V, Tillett, C B, Vigilante, J A, Dettmer, J R, Patterson, S L, Werbovetz, K A, Capers, J, Nichols, D A, Bhattacharjee, A K, Gerena, L

“…The antileishmanial and antimalarial activity of methoxy-substituted chalcones (1,3-diphenyl-2-propen-1-ones) is well established. The few analogs prepared to…”
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Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines by MCDAID, H. M, BHATTACHARYA, S. K, CHEN, X.-T, LIFENG HE, SHEN, H.-J, GUTTERIDGE, C. E, HORWITZ, S. B, DANISHEFSKY, S. J

“…Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar…”
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The Total Synthesis of Eleutherobin by Chen, Xiao-Tao, Bhattacharya, Samit K, Zhou, Bishan, Gutteridge, Clare E, Pettus, Thomas R. R, Danishefsky, Samuel J

“…The total synthesis of the title compound (1), starting with (R)-(−)-α-phellandrene (6), has been accomplished. The synthesis rigorously proves the relative…”
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Coupling of Glycal Derived Thioethyl Glycosyl Donors with Glycal Acceptors. An Advance in the Scope of the Glycal Assembly by Seeberger, Peter H, Eckhardt, Matthias, Gutteridge, Clare E, Danishefsky, Samuel J

“…Glycals were converted into thioethyl glycosyl donors through 1,2-anhydrosugar intermediates. Various participating groups in the C-2 position were examined…”
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The Total Synthesis of Eleutherobin: A Surprise Ending by Chen, Xiao-Tao, Zhou, Bishan, Bhattacharya, Samit K., Gutteridge, Clare E., Pettus, Thomas R. R., Danishefsky, Samuel J.

“…An “sp2–sp3 Stille coupling” of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a…”
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A Convergent Route for the Total Synthesis of the Eleuthesides by Chen, Xiao-Tao, Gutteridge, Clare E., Bhattacharya, Samit K., Zhou, Bishan, Pettus, Thomas R. R., Hascall, Tony, Danishefsky, Samuel J.

“…A ring expansion/ring contraction sequence is one of the key steps in the stereoselective synthesis of the tricyclic eleutheside skeleton 2 from α‐phellandrene…”
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N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists by Gutteridge, Clare E, de Laszlo, Stephen E, Kamenecka, Theodore M, McCauley, Ermengilda, van Riper, Gail, Mumford, Richard A, Kidambi, Usha, Egger, Linda A, Tong, Sharon, Hagmann, William K

“…The SAR of 1-sulfonyl-cyclopentyl carboxylic acid amides, ligands for the VLA-4 integrin, was investigated. This effort resulted in the identification of…”
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A remarkable pyranose to furanose isomerization mediated by an “anomeric" silyloxy function by Bhattacharya, Samit K., Chen, Xiao-Tao, Gutteridge, Clare E., Danishefsky, Samuel J.

“…The conversion of 3 to 6 is accomplished in high yields in three steps. The sequence greatly simplifies access to eleutherobin 1. The conversion of 7 to 6 is…”
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Englische Rechtsprechung 1927 by Gutteridge, C. E., Dr. Rheinstein

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