Search Results - "Gutmann, David H."

The role of microglia and macrophages in glioma maintenance and progression by Hambardzumyan, Dolores, Gutmann, David H, Kettenmann, Helmut

“…Tumor-associated macrophages (TAMs) establish a permissive microenvironment that positively influences glioma formation, progression and response to treatment…”
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Neurofibromatosis type 1: a multidisciplinary approach to care by Hirbe, Angela C, MD, Gutmann, David H, Dr

“…Summary Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high predisposition to develop both benign and malignant tumours…”
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Microglia as Dynamic Cellular Mediators of Brain Function by Wright-Jin, Elizabeth C., Gutmann, David H.

“…Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia…”
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Optic Pathway Gliomas in Neurofibromatosis Type 1 by Campen, Cynthia J., Gutmann, David H.

“…Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition syndromes, in which affected children are prone to the development of…”
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Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma by Chen, Zhihong, Feng, Xi, Herting, Cameron J, Garcia, Virginia Alvarez, Nie, Kai, Pong, Winnie W, Rasmussen, Rikke, Dwivedi, Bhakti, Seby, Sandra, Wolf, Susanne A, Gutmann, David H, Hambardzumyan, Dolores

“…In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and…”
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Putting a stop to nonsense: Revisiting gene correction therapy for neurofibromatosis type 1 by Gutmann, David H.

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Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth by Guo, Xiaofan, Pan, Yuan, Xiong, Min, Sanapala, Shilpa, Anastasaki, Corina, Cobb, Olivia, Dahiya, Sonika, Gutmann, David H.

“…Brain tumors (gliomas) are heterogeneous cellular ecosystems, where non-neoplastic monocytic cells have emerged as key regulators of tumor maintenance and…”
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RAS and beyond: the many faces of the neurofibromatosis type 1 protein by Anastasaki, Corina, Orozco, Paola, Gutmann, David H

“…Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for…”
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Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression by Lauko, Adam, Mu, Zhaomei, Gutmann, David H, Naik, Ulhas P, Lathia, Justin D

“…Tight junction (TJ) proteins are essential for mediating interactions between adjacent cells and coordinating cellular and organ responses. Initial…”
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Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1 by Anastasaki, Corina, Mo, Juan, Chen, Ji-Kang, Chatterjee, Jit, Pan, Yuan, Scheaffer, Suzanne M., Cobb, Olivia, Monje, Michelle, Le, Lu Q., Gutmann, David H.

“…Neuronal activity is emerging as a driver of central and peripheral nervous system cancers. Here, we examined neuronal physiology in mouse models of the tumor…”
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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex by Zeng, Ling‐Hui, Xu, Lin, Gutmann, David H., Wong, Michael

“…Objective Tuberous sclerosis complex (TSC) represents one of the most common genetic causes of epilepsy. TSC gene inactivation leads to hyperactivation of the…”
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Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival by Smithson, Laura J, Gutmann, David H

“…As a critical regulator of cell growth, the mechanistic target of rapamycin (mTOR) protein operates as part of two molecularly and functionally distinct…”
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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis by Yamanaka, Koji, Cleveland, Don W, Chun, Seung Joo, Boillee, Severine, Fujimori-Tonou, Noriko, Yamashita, Hirofumi, Gutmann, David H, Takahashi, Ryosuke, Misawa, Hidemi

“…Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the…”
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Neurofibromatosis Type 1 Revisited by Williams, Virginia C, Lucas, John, Babcock, Michael A, Gutmann, David H, Korf, Bruce, Maria, Bernard L

“…Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a worldwide incidence of approximately 1 per 2500 to 3000 individuals. Caused by a…”
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Oligodendroglial myelination requires astrocyte-derived lipids by Camargo, Nutabi, Goudriaan, Andrea, van Deijk, Anne-Lieke F, Otte, Willem M, Brouwers, Jos F, Lodder, Hans, Gutmann, David H, Nave, Klaus-Armin, Dijkhuizen, Rick M, Mansvelder, Huibert D, Chrast, Roman, Smit, August B, Verheijen, Mark H G

“…In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by…”
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Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia by Chatterjee, Jit, Sanapala, Shilpa, Cobb, Olivia, Bewley, Alice, Goldstein, Andrea K., Cordell, Elizabeth, Ge, Xia, Garbow, Joel R., Holtzman, Michael J., Gutmann, David H.

“…To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic…”
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Optic pathway gliomas in neurofibromatosis-1: Controversies and recommendations by Listernick, Robert, Ferner, Rosalie E., Liu, Grant T., Gutmann, David H.

“…Optic pathway glioma (OPG), seen in 15% to 20% of individuals with neurofibromatosis type 1 (NF1), account for significant morbidity in young children with…”
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Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas by Pekmezci, Melike, Reuss, David E, Hirbe, Angela C, Dahiya, Sonika, Gutmann, David H, von Deimling, Andreas, Horvai, Andrew E, Perry, Arie

“…Cellular schwannoma is an uncommon, but well-recognized, benign peripheral nerve sheath tumor, which can be misdiagnosed as malignant peripheral nerve sheath…”
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Innate Neural Stem Cell Heterogeneity Determines the Patterning of Glioma Formation in Children by Lee, Da Yong, Gianino, Scott M., Gutmann, David H.

“…The concept that gliomas comprise a heterogeneous group of diseases distinguished by their developmental origin raises the intriguing possibility that neural…”
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Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction by Peng, Audrey Yi Tyan, Agrawal, Ira, Ho, Wan Yun, Yen, Yi-Chun, Pinter, Ashley J., Liu, Jerry, Phua, Qi Xuan Cheryl, Koh, Katrianne Bethia, Chang, Jer-Cherng, Sanford, Emma, Man, Jodie Hon Kiu, Wong, Peiyan, Gutmann, David H., Tucker-Kellogg, Greg, Ling, Shuo-Chien

“…Patients with amyotrophic lateral sclerosis (ALS) can have abnormal TDP-43 aggregates in the nucleus and cytosol of their surviving neurons and glia. Although…”
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